Article
Oncology
Rong Li, Xing-Feng Pang, Zhi-Guang Huang, Li-Hua Yang, Zhi-Gang Peng, Jie Ma, Rong-Quan He
Summary: This study revealed that UBE2C mRNA and protein levels were highly expressed in ESCC and may play different roles in different stages of the disease. UBE2C mainly influences the biological function of esophageal cancer through synergistic effects with genes such as CDK1, PTTG1, and SKP2. Additionally, a potential UBE2C-related ceRNA network (HCP5/has-miR-139-5p/UBE2C) was constructed for ESCC.
Article
Biochemistry & Molecular Biology
Yusuke Ishibashi, Satsuki Mochizuki, Keisuke Horiuchi, Hironori Tsujimoto, Keita Kouzu, Yoji Kishi, Yasunori Okada, Hideki Ueno
Summary: This study demonstrates that periostin (POSTN), predominantly produced by cancer-associated fibroblasts (CAFs) in esophageal squamous cell carcinoma (ESCC) tissues, stimulates the activity of A disintegrin and metalloproteinase 17 (ADAM17) through the integrin alpha vI33 or alpha vI35-ERK1/2 pathway, promoting the migration, invasion, proliferation, and colony formation of ESCC cells.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Pathology
Jia Chai, Tianqi Xu, Yanru Yang, Yuan Yuan, Junpeng Xu, Jin Liu, Kaijing Wang, Yao Lv, Jialin Chai, Yulin Kang, Ligang Chen, Junhui Qin, Qingge Jia, Mingyang Li
Summary: Esophageal squamous cell carcinoma (ESCC) is a common cancer with poor prognosis. This study found that overexpression of OTX1 is associated with the prognosis and tumorigenesis of ESCC.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Medicine, General & Internal
Huochun Yi, Hongbing Duan, Wensheng Shi, Zhengjin Liu, Yali Liu
Summary: DEK protein is overexpressed in ESCC tissues, associated with poor prognosis, and can independently predict the prognosis of ESCC patients.
ARCHIVES OF MEDICAL SCIENCE
(2021)
Article
Medicine, General & Internal
Y. Doki, J. A. Ajani, K. Kato, J. Xu, L. Wyrwicz, S. Motoyama, T. Ogata, H. Kawakami, C. -H. Hsu, A. Adenis, F. El Hajbi, M. Di Bartolomeo, M. I. Braghiroli, E. Holtved, S. A. Ostoich, H. R. Kim, M. Ueno, W. Mansoor, W. -C. Yang, T. Liu, J. Bridgewater, T. Makino, I. Xynos, X. Liu, M. Lei, K. Kondo, A. Patel, J. Gricar, I. Chau, Y. Kitagawa
Summary: In patients with advanced esophageal squamous-cell carcinoma, both first-line treatment with nivolumab plus chemotherapy and first-line treatment with nivolumab plus ipilimumab resulted in significantly longer overall survival than chemotherapy alone, with no new safety signals identified.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Biology
H. S. Abboud, D. Camuzi, D. C. Rapozo, P. Fernandes, P. Nicolau-Neto, S. Guaraldi, T. A. Simao, L. F. Ribeiro Pinto, I. M. Gonzaga, S. C. Soares-Lima
Summary: Esophageal squamous cell carcinoma (ESCC) is a common and deadly cancer with limited effective therapies. The study found that while HGF and MET genetic alterations are not common in ESCC, MET expression is consistently upregulated in tumors, suggesting it as a potential therapeutic target. However, intratumor heterogeneity should be considered for eligibility for HGF-MET targeted therapy.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2021)
Article
Medicine, General & Internal
Ming-Chuang Sun, Kang Fang, Zhao-Xing Li, Yuan Chu, Ai-Ping Xu, Zi-Ying Zhao, Zhu-Yun Leng, Yun-Wei Zhang, Ze-Hua Zhang, Li Zhang, Tao Chen, Mei-Dong Xu
Summary: This study found that ETV5 is upregulated in esophageal squamous cell carcinoma (ESCC) and is associated with tumor staging and prognosis. Knockdown of ETV5 and its downstream genes SKA1 and TRPV2 significantly suppress the migration and invasion of ESCC cells. Further experiments revealed that ETV5 can transcriptionally upregulate the expression of SKA1 and TRPV2 and activate MMPs in ESCC progression.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Oncology
Zheng Lin, Wenqing Rao, Zhisheng Xiang, Qiaoyan Zeng, Shuang Liu, Kaili Yu, Jinsong Zhou, Jianwen Wang, Weilin Chen, Yuanmei Chen, Xiane Peng, Zhijian Hu
Summary: The diversity and composition of microbial communities in esophageal tumor tissues were found to be significantly different from tumor-adjacent tissues in patients with esophageal squamous cell carcinoma (ESCC). Certain microbial species were associated with ESCC and were found to be linked to signaling pathways involved in cancer development and progression. These findings suggest that alterations in the esophageal microbiota may play a role in the pathobiology of ESCC.
Article
Chemistry, Multidisciplinary
Qingfu Zhu, Liu Huang, Qinsi Yang, Zheng Ao, Rui Yang, Jonathan Krzesniak, Doudou Lou, Liang Hu, Xiaodan Dai, Feng Guo, Fei Liu
Summary: Metabolomic analysis of plasma exosomes in patients with ESCC revealed 196 metabolites, with a marker set of 3'-UMP, palmitoleic acid, palmitaldehyde, and isobutyl decanoate showing high accuracy in predicting ESCC recurrence. These exosome metabolome signatures, likely associated with cancer metabolism, could potentially serve as novel biomarkers for diagnosis and prognosis of ESCC.
Article
Oncology
Dongxian Jiang, Haixing Wang, Minying Deng, Qi Song, Yufeng Liu, Rui Peng, Lei Xu, Jieakesu Su, Chen Xu, Yingyong Hou
Summary: The number of diagnosed esophageal basaloid squamous cell carcinoma (EBSCC) has been increasing recently, but available data on EBSCC are limited. A retrospective analysis of 165 EBSCC and 515 conventional esophageal squamous cell carcinoma (ESCC) showed that EBSCC had similar prognosis to ESCC in pIA-B stage, pIIA-B stage, pIIIA-B stage, and pIVA-B stage. Pure EBSCC did not have poorer survival compared to mixed EBSCC with concomitant ESCC or other components.
Article
Biotechnology & Applied Microbiology
Wei Huang, Ju Zhu, Haoming Shi, Qingchen Wu, Cheng Zhang
Summary: The study found that in esophageal squamous cell carcinoma (ESCC), ITGA2 promotes proliferation, invasion, and migration, inhibits apoptosis, and promotes epithelial-mesenchymal transition (EMT), possibly through the FAK/AKT signaling pathway. These findings highlight the therapeutic potential of ITGA2 in ESCC.
ONCOTARGETS AND THERAPY
(2021)
Article
Cell Biology
Weixiong Yang, Chang-Han Chen, Minghan Jia, Xiangbin Xing, Lu Gao, Hsin-Ting Tsai, Zhanfei Zhang, Zhenguo Liu, Bo Zeng, Sai-Ching Jim Yeung, Mong-Hong Lee, Chao Cheng
Summary: The study revealed significant differences in the microbiota composition between patients with ESCC and those with PN esophagus, with the former showing reduced microbial diversity and decreased abundances of specific taxa. Functional analysis indicated altered nitrate reductase and nitrite reductase functions in the microbiota of ESCC patients. These findings suggest that specific microbes and microbiota may influence the development of ESCC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Genetics & Heredity
Adam N. Bennett, Rui Xuan Huang, Qian He, Nikki P. Lee, Wing-Kin Sung, Kei Hang Katie Chan
Summary: Esophageal cancer, particularly esophageal squamous cell carcinoma, is a significant challenge globally, with high incidence and mortality rates. The limited number of effective therapeutic options contributes to the high mortality rate. Repurposing existing drugs approved for other diseases through drug repositioning is a more time and cost-effective strategy. This study identified potential therapeutic drugs for esophageal cancer patients through gene expression analysis and network analysis, including both known drugs like Doxorubicin and potential psychiatric drugs like Venlafaxine.
FRONTIERS IN GENETICS
(2022)
Article
Immunology
Zongdan Jiang, Jun Wang, Ziyang Shen, Zhenyu Zhang, Shukui Wang
Summary: This study revealed significant differences in microbial diversity between esophageal cancer patients and healthy controls, as well as distinct changes at the genus level. Additionally, esophageal adenocarcinoma patients showed differences in bacterial composition compared to esophagitis patients.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Oncology
Shao Wenhua, Takaaki Tsunematsu, Masaaki Umeda, Hiroaki Tawara, Natsumi Fujiwara, Yasuhiro Mouri, Rieko Arakaki, Naozumi Ishimaru, Yasusei Kudo
Summary: Recently, it has been reported that the partial-epithelial-mesenchymal transition (p-EMT) program is associated with metastasis in head and neck squamous cell carcinoma (HNSCC). The study focused on the role of a novel cancer-specific POSTN isoform, Iso5, in HNSCC and found that Iso5 promoted invasion together with another isoform, Iso3. The researchers suggest that Iso5 can be a useful marker for detecting cancer cells undergoing p-EMT and a potential target for diagnosis and therapy in HNSCC.