A new sensitive PCR assay for one-step detection of 12 IDH1/2 mutations in glioma

5-azacytidine reduces methylation, promotes differentiation and induces tumor regression in a patient-derived IDH1 mutant glioma xenograft

(2015) Alexandra Borodovsky et al.   Oncotarget

Efficient induction of differentiation and growth inhibition in IDH1 mutant glioma cells by the DNMT Inhibitor Decitabine.

(2015) Sevin Turcan et al.   Oncotarget

Benefit From Procarbazine, Lomustine, and Vincristine in Oligodendroglial Tumors Is Associated With Mutation ofIDH

(2014) J. Gregory Cairncross et al.   JOURNAL OF CLINICAL ONCOLOGY

Predictive biomarkers in adult gliomas

(2013) Laure Thomas et al.   CURRENT OPINION IN ONCOLOGY

Interlaboratory comparison of IDH mutation detection

(2013) Martin J. van den Bent et al.   JOURNAL OF NEURO-ONCOLOGY

Molecular neuro-oncology in clinical practice: a new horizon

(2013) Michael Weller et al.   LANCET ONCOLOGY

Expanding the spectrum of IDH1 mutations in gliomas

(2013) Ruta Gupta et al.   MODERN PATHOLOGY

IDH1 mutant malignant astrocytomas are more amenable to surgical resection and have a survival benefit associated with maximal surgical resection

(2013) Jason Beiko et al.   NEURO-ONCOLOGY

Prognostic or predictive value of MGMT promoter methylation in gliomas depends on IDH1 mutation

(2013) W. Wick et al.   NEUROLOGY

An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells

(2013) D. Rohle et al.   SCIENCE

BRAF Alterations Are Frequent in Cerebellar Low-Grade Astrocytomas With Diffuse Growth Pattern

(2012) Cristiane M. Ida et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Prognostic Value of IDH1 Mutations Identified with PCR-RFLP Assay in Glioblastoma Patients

(2012) Mateusz Bujko et al.   Molecular Diagnosis & Therapy

IDH testing in diagnostic neuropathology: review and practical guideline article invited by the Euro-CNS research committee

(2011) M. Preusser et al.   CLINICAL NEUROPATHOLOGY

Value and Limitations of Immunohistochemistry and Gene Sequencing for Detection of theIDH1-R132HMutation in Diffuse Glioma Biopsy Specimens

(2011) Matthias Preusser et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Mutation-specific IDH1 antibody differentiates oligodendrogliomas and oligoastrocytomas from other brain tumors with oligodendroglioma-like morphology

(2010) David Capper et al.   ACTA NEUROPATHOLOGICA

The Next Generation of Glioma Biomarkers: MGMT Methylation, BRAF Fusions and IDH1 Mutations

(2010) Andreas Von Deimling et al.   BRAIN PATHOLOGY

IDH1 and IDH2 Mutations Are Prognostic but not Predictive for Outcome in Anaplastic Oligodendroglial Tumors: A Report of the European Organization for Research and Treatment of Cancer Brain Tumor Group

(2010) M. J. van den Bent et al.   CLINICAL CANCER RESEARCH

Guidelines on management of low-grade gliomas: report of an EFNS-EANO* Task Force

(2010) R. Soffietti et al.   EUROPEAN JOURNAL OF NEUROLOGY

COLD PCR HRM: a highly sensitive detection method for IDH1 mutations

(2010) Blandine Boisselier et al.   HUMAN MUTATION

Detection of IDH1 and IDH2 Mutations by Fluorescence Melting Curve Analysis as a Diagnostic Tool for Brain Biopsies

(2010) Craig Horbinski et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

A Pyrosequencing-Based Assay for the Rapid Detection of IDH1 Mutations in Clinical Samples

(2010) Prashanth Setty et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

A Commercial Real-Time PCR Kit Provides Greater Sensitivity than Direct Sequencing to Detect KRAS Mutations

(2010) Bárbara Angulo et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Comparison of Sanger Sequencing, Pyrosequencing, and Melting Curve Analysis for the Detection of KRAS Mutations

(2010) Athanasios C. Tsiatis et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

IDH1 or IDH2 mutations predict longer survival and response to temozolomide in low-grade gliomas

(2010) C. Houillier et al.   NEUROLOGY

Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas

(2009) Christian Hartmann et al.   ACTA NEUROPATHOLOGICA

PCR- and Restriction Endonuclease-Based Detection ofIDH1Mutations

(2009) Jochen Meyer et al.   BRAIN PATHOLOGY

Characterization of R132H Mutation-specific IDH1 Antibody Binding in Brain Tumors

(2009) David Capper et al.   BRAIN PATHOLOGY

Molecular Predictors of Progression-Free and Overall Survival in Patients With Newly Diagnosed Glioblastoma: A Prospective Translational Study of the German Glioma Network

(2009) Michael Weller et al.   JOURNAL OF CLINICAL ONCOLOGY

NOA-04 Randomized Phase III Trial of Sequential Radiochemotherapy of Anaplastic Glioma With Procarbazine, Lomustine, and Vincristine or Temozolomide

(2009) Wolfgang Wick et al.   JOURNAL OF CLINICAL ONCOLOGY

IDH1 mutations in low-grade astrocytomas predict survival but not response to temozolomide

(2009) H. J. Dubbink et al.   NEUROLOGY

IDH1andIDH2Mutations in Gliomas

(2009) Hai Yan et al.   NEW ENGLAND JOURNAL OF MEDICINE