Accumulation of α-synuclein in dementia with Lewy bodies is associated with decline in the α-synuclein-degrading enzymes kallikrein-6 and calpain-1

Environmental neurotoxic challenge of conditional alpha-synuclein transgenic mice predicts a dopaminergic olfactory-striatal interplay in early PD

(2014) Silke Nuber et al.   ACTA NEUROPATHOLOGICA

Reduced Vascular Endothelial Growth Factor and Capillary Density in the Occipital Cortex in Dementia with Lewy Bodies

(2014) Scott Miners et al.   BRAIN PATHOLOGY

Resistance of naturally secreted α-synuclein to proteolysis

(2014) Methodios Ximerakis et al.   FASEB JOURNAL

Overexpression of the calpain-specific inhibitor calpastatin reduces human alpha-Synuclein processing, aggregation and synaptic impairment in [A30P]αSyn transgenic mice

(2014) Meike Diepenbroek et al.   HUMAN MOLECULAR GENETICS

Evaluating the relationship between amyloid-β and α-synuclein phosphorylated at Ser129 in dementia with Lewy bodies and Parkinson’s disease

(2014) Marta Swirski et al.   Alzheimers Research & Therapy

Calpain 1 induce lysosomal permeabilization by cleavage of lysosomal associated membrane protein 2

(2013) Gloria E. Villalpando Rodriguez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Low CSF Levels of Both α-Synuclein and the α-Synuclein Cleaving Enzyme Neurosin in Patients with Synucleinopathy

(2013) Malin Wennström et al.   PLoS One

Protein degradation pathways in Parkinson’s disease: curse or blessing

(2012) Darius Ebrahimi-Fakhari et al.   ACTA NEUROPATHOLOGICA

Alpha-synuclein and Protein Degradation Systems: a Reciprocal Relationship

(2012) Maria Xilouri et al.   MOLECULAR NEUROBIOLOGY

Exosomal cell-to-cell transmission of alpha synuclein oligomers

(2012) Karin M Danzer et al.   Molecular Neurodegeneration

Lentivirus Mediated Delivery of Neurosin Promotes Clearance of Wild-type α-Synuclein and Reduces the Pathology in an α-Synuclein Model of LBD

(2012) Brian Spencer et al.   MOLECULAR THERAPY

National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach

(2011) Thomas J. Montine et al.   ACTA NEUROPATHOLOGICA

Mechanistic involvement of the calpain-calpastatin system in Alzheimer neuropathology

(2011) Makoto Higuchi et al.   FASEB JOURNAL

Upregulation of cathepsin D in the caudate nucleus of primates with experimental parkinsonism

(2011) Sowmya V Yelamanchili et al.   Molecular Neurodegeneration

Control of basal autophagy by calpain1 mediated cleavage of ATG5

(2010) Hong-Guang Xia et al.   Autophagy

Kallikrein-related peptidase 6 in Alzheimer's disease and vascular dementia

(2010) Emma L. Ashby et al.   BRAIN RESEARCH

Extracellular neurosin degrades α-synuclein in cultured cells

(2010) Harutsugu Tatebe et al.   NEUROSCIENCE RESEARCH

Relationship between alpha synuclein phosphorylation, proteasomal inhibition and cell death: relevance to Parkinson’s disease pathogenesis

(2009) Kai-Yin Chau et al.   JOURNAL OF NEUROCHEMISTRY

Cholinesterase inhibitors may increase phosphorylated tau in Alzheimer’s disease

(2009) Katy A. Chalmers et al.   JOURNAL OF NEUROLOGY

Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo

(2009) Valerie Cullen et al.   Molecular Brain

Cathepsin D Is the Main Lysosomal Enzyme Involved in the Degradation of α-Synuclein and Generation of Its Carboxy-Terminally Truncated Species†

(2008) Daniel Sevlever et al.   BIOCHEMISTRY

Increased α-synuclein aggregation following limited cleavage by certain matrix metalloproteinases

(2008) Johannes Levin et al.   EXPERIMENTAL NEUROLOGY

Cleavage of normal and pathological forms of α-synuclein by neurosin in vitro

(2008) Takashi Kasai et al.   NEUROSCIENCE LETTERS

Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity

(2008) Liyan Qiao et al.   Molecular Brain

Activation of the calpain/cdk5/p25 pathway in the girus cinguli in Parkinson's disease

(2007) Daniel Alvira et al.   PARKINSONISM & RELATED DISORDERS