Systems biology approaches to study the molecular effects of caloric restriction and polyphenols on aging processes

The sirtuins, oxidative stress and aging: an emerging link

(2016) Philip I. Merksamer et al.   Aging-US

Late-onset caloric restriction alters skeletal muscle metabolism by modulating pyruvate metabolism

(2015) Chiao-nan (Joyce) Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Transcriptomic and metabolomic data integration

(2015) Rachel Cavill et al.   BRIEFINGS IN BIOINFORMATICS

Health in an ageing world—what do we know?

(2015) Richard Suzman et al.   LANCET

Methods of integrating data to uncover genotype–phenotype interactions

(2015) Marylyn D. Ritchie et al.   NATURE REVIEWS GENETICS

Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders

(2015) Neelroop N. Parikshak et al.   NATURE REVIEWS GENETICS

Caloric restriction increases ketone bodies metabolism and preserves blood flow in aging brain

(2015) Ai-Ling Lin et al.   NEUROBIOLOGY OF AGING

Resveratrol up-regulates AMPA receptor expression via AMP-activated protein kinase-mediated protein translation

(2015) Guan Wang et al.   NEUROPHARMACOLOGY

SCUDO: a tool for signature-based clustering of expression profiles

(2015) Mario Lauria et al.   NUCLEIC ACIDS RESEARCH

WikiPathways: capturing the full diversity of pathway knowledge

(2015) Martina Kutmon et al.   NUCLEIC ACIDS RESEARCH

Quantification of biological aging in young adults

(2015) Daniel W. Belsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Practicality of Intermittent Fasting in Humans and its Effect on Oxidative Stress and Genes Related to Aging and Metabolism

(2015) Martin P. Wegman et al.   REJUVENATION RESEARCH

System Model Network for Adipose Tissue Signatures Related to Weight Changes in Response to Calorie Restriction and Subsequent Weight Maintenance

(2015) Emilie Montastier et al.   PLoS Computational Biology

Calorie Restriction Suppresses Age-Dependent Hippocampal Transcriptional Signatures

(2015) Marissa J. Schafer et al.   PLoS One

Altered proteome turnover and remodeling by short-term caloric restriction or rapamycin rejuvenate the aging heart

(2014) Dao-Fu Dai et al.   AGING CELL

SAMNetWeb: identifying condition-specific networks linking signaling and transcription

(2014) S. J. C. Gosline et al.   BIOINFORMATICS

A multivariate approach to the integration of multi-omics datasets

(2014) Chen Meng et al.   BMC BIOINFORMATICS

Network signatures link hepatic effects of anti-diabetic interventions with systemic disease parameters

(2014) Thomas Kelder et al.   BMC Systems Biology

Nutrition and brain aging: how can we move ahead?

(2014) P Barberger-Gateau   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Caloric Restriction Impedes Age-Related Decline of Mitochondrial Function and Neuronal Activity

(2014) Ai-Ling Lin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Integrated enrichment analysis and pathway-centered visualization of metabolomics, proteomics, transcriptomics, and genomics data by using the InCroMAP software

(2014) Johannes Eichner et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Effects of Resveratrol on Memory Performance, Hippocampal Functional Connectivity, and Glucose Metabolism in Healthy Older Adults

(2014) A. V. Witte et al.   JOURNAL OF NEUROSCIENCE

Modulating effect of SIRT1 activation induced by resveratrol on Foxo1-associated apoptotic signalling in senescent heart

(2014) Thomas K. Sin et al.   JOURNAL OF PHYSIOLOGY-LONDON

Caloric restriction can improve learning ability in C57/BL mice via regulation of the insulin-PI3K/Akt signaling pathway

(2014) Lina Ma et al.   NEUROLOGICAL SCIENCES

Cardiorespiratory fitness and cognitive function in middle age: The CARDIA Study

(2014) N. Zhu et al.   NEUROLOGY

A long-term intensive lifestyle intervention and physical function: The look AHEAD Movement and Memory Study

(2014) Denise K. Houston et al.   Obesity

Oxidative stress and genetic markers of suboptimal antioxidant defense in the aging brain: a theoretical review

(2014) Lauren E. Salminen et al.   REVIEWS IN THE NEUROSCIENCES

Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study

(2013) Marian Beekman et al.   AGING CELL

A consensus orthogonal partial least squares discriminant analysis (OPLS-DA) strategy for multiblock Omics data fusion

(2013) Julien Boccard et al.   ANALYTICA CHIMICA ACTA

Joint and individual variation explained (JIVE) for integrated analysis of multiple data types

(2013) Eric F. Lock et al.   Annals of Applied Statistics

Strengths and limitations of microarray-based phenotype prediction: lessons learned from the IMPROVER Diagnostic Signature Challenge

(2013) Adi L. Tarca et al.   BIOINFORMATICS

3Omics: a web-based systems biology tool for analysis, integration and visualization of human transcriptomic, proteomic and metabolomic data

(2013) Tien-Chueh Kuo et al.   BMC Systems Biology

Calorie restriction and resveratrol supplementation prevent age-related DNA and RNA oxidative damage in a non-human primate

(2013) J. Marchal et al.   EXPERIMENTAL GERONTOLOGY

Resveratrol vs. calorie restriction: Data from rodents to humans

(2013) Yan Y. Lam et al.   EXPERIMENTAL GERONTOLOGY

Short-term caloric restriction, resveratrol, or combined treatment regimens initiated in late-life alter mitochondrial protein expression profiles in a fiber-type specific manner in aged animals

(2013) Anna-Maria Joseph et al.   EXPERIMENTAL GERONTOLOGY

A Dietary Regimen of Caloric Restriction or Pharmacological Activation of SIRT1 to Delay the Onset of Neurodegeneration

(2013) J. Graff et al.   JOURNAL OF NEUROSCIENCE

Virgin olive oil supplementation and long-term cognition: the Predimed-Navarra randomized, trial

(2013) Elena H. Martinez-Lapiscina et al.   Journal of Nutrition Health & Aging

Dietary restriction attenuates age-associated muscle atrophy by lowering oxidative stress in mice even in complete absence of CuZnSOD

(2012) Young C. Jang et al.   AGING CELL

NetWalker: a contextual network analysis tool for functional genomics

(2012) Kakajan Komurov et al.   BMC GENOMICS

The Intersection Between Aging and Cardiovascular Disease

(2012) Brian J. North et al.   CIRCULATION RESEARCH

Inflamm-ageing

(2012) Elisa Cevenini et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Network analysis of adipose tissue gene expression highlights altered metabolic and regulatory transcriptomic activity in high-fat-diet-fed IL-1RI knockout mice

(2012) Melissa J. Morine et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

A Gene-Phenotype Network Based on Genetic Variability for Drought Responses Reveals Key Physiological Processes in Controlled and Natural Environments

(2012) David Rengel et al.   PLoS One

Dissecting the Gene Network of Dietary Restriction to Identify Evolutionarily Conserved Pathways and New Functional Genes

(2012) Daniel Wuttke et al.   PLoS Genetics

AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network

(2011) Antero Salminen et al.   AGEING RESEARCH REVIEWS

Integrated pathway-level analysis of transcriptomics and metabolomics data with IMPaLA

(2011) Atanas Kamburov et al.   BIOINFORMATICS

Metscape 2 bioinformatics tool for the analysis and visualization of metabolomics and gene expression data

(2011) Alla Karnovsky et al.   BIOINFORMATICS

Interactome Networks and Human Disease

(2011) Marc Vidal et al.   CELL

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

Chronic low-grade inflammation and age-related sarcopenia

(2011) Ingo Beyer et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Physical frailty in older adults is associated with metabolic and atherosclerotic risk factors and cognitive impairment independent of muscle mass

(2011) Jenny S. W. Lee et al.   Journal of Nutrition Health & Aging

Vitamin status in elderly people in relation to the use of nutritional supplements

(2011) Elisabeth Fabian et al.   Journal of Nutrition Health & Aging

Caloric restriction

(2011) John R. Speakman et al.   MOLECULAR ASPECTS OF MEDICINE

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

(2011) Saul A. Villeda et al.   NATURE

Cognitive Performances Are Selectively Enhanced during Chronic Caloric Restriction or Resveratrol Supplementation in a Primate

(2011) Alexandre Dal-Pan et al.   PLoS One

Inflammation as “common soil” of the multifactorial diseases

(2010) Rossana Scrivo et al.   AUTOIMMUNITY REVIEWS

Resveratrol, sirtuins, and the promise of a DR mimetic

(2010) Joseph A. Baur   MECHANISMS OF AGEING AND DEVELOPMENT

Metabolomic and transcriptomic stress response of Escherichia coli

(2010) Szymon Jozefczuk et al.   Molecular Systems Biology

Trends in modeling Biomedical Complex Systems

(2009) Luciano Milanesi et al.   BMC BIOINFORMATICS

Caloric restriction improves memory in elderly humans

(2009) A. V. Witte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span

(2008) Kevin J. Pearson et al.   Cell Metabolism

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH

A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice

(2008) Jamie L. Barger et al.   PLoS One