Review
Biochemistry & Molecular Biology
Caterina Anania, Giulia Brindisi, Ivana Martinelli, Edoardo Bonucci, Miriam D'Orsi, Sara Ialongo, Anna Nyffenegger, Tonia Raso, Mattia Spatuzzo, Giovanna De Castro, Anna Maria Zicari, Carlo Carraro, Maria Grazia Piccioni, Francesca Olivero
Summary: Atopic dermatitis is a chronic inflammatory skin disorder with increasing prevalence in children and adults. The potential role of probiotics in preventing atopic dermatitis has generated considerable interest, as they can modulate systemic inflammation and immune responses. However, the molecular mechanisms and efficacy of probiotics in anti-allergic effects are still unclear and controversial.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Irfan A. Rather, Byung-Chun Kim, Lee-Ching Lew, Seong-Kwan Cha, Jong Hwan Lee, Gyeong-Jun Nam, Rajib Majumder, Jeongheui Lim, Seul-Ki Lim, Young-Joon Seo, Yong-Ha Park
Summary: The study indicates that oral administration of L. sakeiproBio65 in both viable and non-viable forms may lead to positive improvements in alleviating symptoms of atopic dermatitis, improving skin barrier function, and reducing skin inflammation.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2021)
Article
Dermatology
K. Mossing, A. Dizdarevic, A. Svensson, A. Sonesson
Summary: Patch testing can improve the quality of life of patients with allergic contact dermatitis, although additional interventions did not show significant improvement. Further research is needed to explore factors that affect quality of life in these patients and identify interventions to improve it.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Review
Allergy
Raj Chovatiya, Amy S. Paller
Summary: Atopic dermatitis (AD) is a chronic inflammatory skin disorder with limited treatment options. Recent studies have shown that both topical and systemic Janus kinase (JAK) inhibitors hold promise in treating AD, with further research needed to fully understand their efficacy and safety.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jong-Hwa Kim, Kiyoung Kim, Wonyong Kim
Summary: This study aimed to restore gut microbiota through fecal microbiota transplantation (FMT) to ameliorate atopic dermatitis (AD) in mice. FMT resulted in the restoration of gut microbiota, increased SCFA levels, restored Th1/Th2 balance, reduced allergic responses, and showed potential as a new therapy for AD.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)
Article
Multidisciplinary Sciences
Ji Hyun Lee, Ahhyung Choi, Yunha Noh, In-Sun Oh, Ja-Young Jeon, Hyun-Jeong Yoo, Ju-Young Shin, Sang Wook Son
Summary: This study aimed to examine the treatment patterns of atopic dermatitis (AD) in Asians, and found significant differences in treatment between pediatric and adult patients. Topical corticosteroids and antihistamines were the most commonly prescribed medications, but the use of topical corticosteroids decreased with age. Cyclosporine was the most frequently prescribed immunosuppressant. Pediatric patients were more likely to discontinue treatment, and restart of treatment for moderate-to-severe AD was earlier than overall AD.
SCIENTIFIC REPORTS
(2022)
Review
Dermatology
Regina Foelster-Holst
Summary: The physical barrier function of the skin is supported by the (epi-)dermal immune system and the skin's own microbiome. Atopic dermatitis is characterized by changes in the skin microbiome, with Staphylococcus aureus playing a dominant role. The bacteria further weaken the compromised skin barrier function and exacerbate inflammation in patients with atopic dermatitis. However, understanding dermal dysbiosis offers new treatment options for the disease.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2022)
Review
Dermatology
Katrina Abuabara, Sinead M. Langan
Summary: Atopic dermatitis is a common chronic inflammatory skin disease that can occur at any age and has variable patterns of disease activity over time. Genetic factors and parental history of atopy are consistent predictors of more persistent disease. Age-related differences in molecular markers are being studied, although there is a lack of longitudinal data. Preventive measures such as breastfeeding, probiotics, and emollients have shown inconsistent long-term benefits in randomized trials. Future research should focus on disease activity beyond early adulthood and the impact of treatments on long-term outcomes.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Acoustics
T. Nau, C. Schoenmann, B. Hindelang, L. Riobo, A. Doll, S. Schneider, L. Englert, H. He, T. Biedermann, U. Darsow, F. Lauffer, V. Ntziachristos, J. Aguirre
Summary: Atopic dermatitis (AD) is a common chronic inflammatory skin disease. Current severity assessments rely on visual observation and subjective symptoms. However, optoacoustic mesoscopy has been shown to provide precise biomarkers of inflammation, potentially enabling more accurate evaluations of AD severity.
Article
Medicine, General & Internal
Yajia Li, Danrong Jing, Yuzhou Huang, Juan Su, Jie Li, Ji Li, Juan Tao, Shijun Shan, Xiaohui Wang, Xiaojing Kang, Bin Wu, Xiang Chen, Minxue Shen, Yi Xiao
Summary: Preschool upper respiratory tract infections and antibiotic use significantly increase the risk of atopic and allergic skin diseases in young adulthood.
Article
Allergy
Carina Venter, Michaela P. Palumbo, Katherine A. Sauder, Deborah H. Glueck, Andrew H. Liu, Ivana V. Yang, Miriam Ben-Abdallah, David M. Fleischer, Dana Dabelea
Summary: The study found that children born to women with a history of asthma have a significantly increased risk of asthma, atopic dermatitis/eczema, and wheeze, but not allergic rhinitis or food allergies. Maternal history of allergic rhinitis was not associated with child allergy outcomes, while maternal history of both asthma and allergic rhinitis was only associated with child atopic dermatitis/eczema.
WORLD ALLERGY ORGANIZATION JOURNAL
(2021)
Article
Dermatology
Linda Stein Gold, Diamant Thaci, Jacob P. Thyssen, Melinda Gooderham, Vivian Laquer, Angela Moore, Chitra R. Natalie, Fangyi Zhao, Eric Meskimen, Hany Elmaraghy, Sonia Montmayeur, Gaia Gallo, Gemma Jimenez, Marjolein de Bruin-Weller
Summary: This study reports the integrated safety of lebrikizumab in adults and adolescents with moderate-to-severe atopic dermatitis. The results show that lebrikizumab has a good safety profile, with most adverse events being non-serious, mild or moderate, and not leading to treatment discontinuation.
AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
(2023)
Article
Medicine, General & Internal
Yu-Jih Su, Sheng-Dean Luo, Chung-Yuan Hsu, Ho-Chang Kuo
Summary: This study compared gut microbiota differences between patients with eczema, hives, and allergic rhinitis, revealing significant differences in gut flora between skin allergy and nose allergy patients, indicating the existence of gut-skin and gut-nose axes. Certain Bacteroidales species may be a clinical link between gut flora and skin allergies.
Article
Allergy
Miisa Komulainen, Lotta Saros, Tero Vahlberg, Merja Nermes, Tuomas Jartti, Kirsi Laitinen
Summary: The effects of fish oil and probiotics on the risk of allergic diseases in infants were studied. The results showed that except for the probiotic intervention which decreased the risk of recurrent wheezing in two-year-old infants, the use of fish oil and/or probiotics from early pregnancy onwards did not lower the odds of childhood allergic diseases or atopy.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Jordan Zeldin, Prem Prashant Chaudhary, Jacquelyn Spathies, Manoj Yadav, Brandon N. D'Souza, Mohammadali E. Alishahedani, Portia Gough, Jobel Matriz, Andrew J. Ghio, Yue Li, Ashleigh A. Sun, Lawrence F. Eichenfield, Eric L. Simpson, Ian A. Myles
Summary: Atopic dermatitis is a chronic inflammatory skin condition that is increasing in industrial nations, possibly due to environmental factors. The dysbiosis associated with atopic dermatitis may signal microbial adaptations to modern pollutants. R. mucosa has been found to fix nitrogen and produce protective glycerolipids and ceramide by-products, which can impact atopic dermatitis.