Journal
JOURNAL OF TISSUE ENGINEERING
Volume 9, Issue -, Pages -Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/2041731418788509
Keywords
Brushite; calcium phosphate; cryostructuring; hydrogel; mineralization; silk fibroin scaffolds
Categories
Funding
- Deutsche Forschungsgemeinschaft (DFG) [GB 1/20-1, GR 3232/3-1]
- DFG State Major Instrumentation Program [INST 1522/58-1]
Ask authors/readers for more resources
Silk fibroin is commonly used as scaffold material for tissue engineering applications. In combination with a mineralization with different calcium phosphate phases, it can also be applied as material for bone regeneration. Here, we present a study which was performed to produce mineralized silk fibroin scaffolds with controlled macroporosity. In contrast to former studies, our approach focused on a simultaneous gelation and mineralization of silk fibroin by immersion of frozen silk fibroin monoliths in acidic calcium phosphate solutions. This was achieved by thawing frozen silk fibroin monoliths in acidic calcium phosphate solution, leading to the precipitation of monocalcium phosphate within the silk fibroin matrix. In the second approach, a conversion of incorporated -tricalcium phosphate particles into brushite was successfully achieved. Furthermore, a controlled cryostructuring process of silk fibroin scaffolds was carried out leading to the formation of parallel-oriented pores with diameters of 30-50 mu m.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available