Premotor biomarkers for Parkinson's disease - a promising direction of research

Gait alterations in healthy carriers of the LRRK2 G2019S mutation

(2011) Anat Mirelman et al.   ANNALS OF NEUROLOGY

Acid β-glucosidase mutants linked to gaucher disease, parkinson disease, and lewy body dementia alter α-synuclein processing

(2011) Valerie Cullen et al.   ANNALS OF NEUROLOGY

Preclinical Biomarkers of Parkinson Disease

(2011) Yuncheng Wu et al.   ARCHIVES OF NEUROLOGY

Salivary α-synuclein and DJ-1: potential biomarkers for Parkinson's disease

(2011) Ivana Devic et al.   BRAIN

Oxidized DJ-1 Interacts with the Mitochondrial Protein BCL-XL

(2011) Haigang Ren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein Interacts with Glucocerebrosidase Providing a Molecular Link between Parkinson and Gaucher Diseases

(2011) Thai Leong Yap et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protection Against Dopaminergic Neurodegeneration in Parkinson’s Disease–Model Animals by a Modulator of the Oxidized Form of DJ-1, a Wild-type of Familial Parkinson’s Disease–Linked PARK7

(2011) Masatoshi Inden et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

α-Synuclein and tau concentrations in cerebrospinal fluid of patients presenting with parkinsonism: a cohort study

(2011) Brit Mollenhauer et al.   LANCET NEUROLOGY

Mutations in the glucocerebrosidase gene confer a risk for Parkinson disease in North Africa

(2011) S. Lesage et al.   NEUROLOGY

Serotonin-dependent depression in Parkinson’s disease: A role for the subthalamic nucleus?

(2011) Sonny K.H. Tan et al.   NEUROPHARMACOLOGY

α-Synuclein Reactive Antibodies as Diagnostic Biomarkers in Blood Sera of Parkinson's Disease Patients

(2011) Kiran Yanamandra et al.   PLoS One

Exploring the link between glucocerebrosidase mutations and parkinsonism

(2011) Wendy Westbroek et al.   TRENDS IN MOLECULAR MEDICINE

Web-Based Genome-Wide Association Study Identifies Two Novel Loci and a Substantial Genetic Component for Parkinson's Disease

(2011) Chuong B. Do et al.   PLoS Genetics

Lewy pathology in the submandibular gland of individuals with incidental Lewy body disease and sporadic Parkinson’s disease

(2010) Kelly Del Tredici et al.   ACTA NEUROPATHOLOGICA

Glucocerebrosidase is present in α-synuclein inclusions in Lewy body disorders

(2010) Ozlem Goker-Alpan et al.   ACTA NEUROPATHOLOGICA

Genome-Wide Association Study Confirms SNPs inSNCAand theMAPTRegion as Common Risk Factors for Parkinson Disease

(2010) Todd L. Edwards et al.   ANNALS OF HUMAN GENETICS

Cerebrospinal fluid biomarkers for Parkinson disease diagnosis and progression

(2010) Min Shi et al.   ANNALS OF NEUROLOGY

When Does Parkinson Disease Start?

(2010) Rodolfo Savica et al.   ARCHIVES OF NEUROLOGY

Urate: a novel biomarker of Parkinson’s disease risk, diagnosis and prognosis

(2010) Sara Cipriani et al.   Biomarkers in Medicine

Quantification of α-synuclein in cerebrospinal fluid as a biomarker candidate: review of the literature and considerations for future studies

(2010) Brit Mollenhauer et al.   Biomarkers in Medicine

Magnetic resonance imaging markers of Parkinson’s disease nigrostriatal signature

(2010) Patrice Péran et al.   BRAIN

DJ-1 and α-synuclein in human cerebrospinal fluid as biomarkers of Parkinson’s disease

(2010) Zhen Hong et al.   BRAIN

Biomarkers in Parkinson’s Disease

(2010) John C. Morgan et al.   Current Neurology and Neuroscience Reports

Using ‘omics’ to define pathogenesis and biomarkers of Parkinson’s disease

(2010) W Michael Caudle et al.   Expert Review of Neurotherapeutics

Understanding the molecular basis of Parkinson’s disease, identification of biomarkers and routes to therapy

(2010) Philip A Robinson   Expert Review of Proteomics

Large-scale screening of the Gaucher's disease-related glucocerebrosidase gene in Europeans with Parkinson's disease

(2010) Suzanne Lesage et al.   HUMAN MOLECULAR GENETICS

Olfaction in the Elderly: A Cross-Sectional Analysis Comparing Parkinson's Disease with Controls and Other Disorders

(2010) Jonathan Mckinnon et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Neuropathology of sporadic Parkinson disease before the appearance of parkinsonism: preclinical Parkinson disease

(2010) Isidre Ferrer et al.   JOURNAL OF NEURAL TRANSMISSION

Olfactory dysfunction and cardiovascular dysautonomia in Parkinson’s disease

(2010) Hisayoshi Oka et al.   JOURNAL OF NEUROLOGY

Enhanced Striatal Dopamine Transmission and Motor Performance with LRRK2 Overexpression in Mice Is Eliminated by Familial Parkinson's Disease Mutation G2019S

(2010) X. Li et al.   JOURNAL OF NEUROSCIENCE

Glucocerebrosidase Gene L444P mutation is a risk factor for Parkinson's disease in Chinese population

(2010) Qi-Ying Sun et al.   MOVEMENT DISORDERS

Anxious personality predicts an increased risk of Parkinson's disease

(2010) James H. Bower et al.   MOVEMENT DISORDERS

Distinguishing SWEDDs patients with asymmetric resting tremor from Parkinson's disease: A clinical and electrophysiological study

(2010) Petra Schwingenschuh et al.   MOVEMENT DISORDERS

Plasma α-synuclein in patients with Parkinson's disease with and without treatment

(2010) Raquel Duran et al.   MOVEMENT DISORDERS

Severity of REM atonia loss in idiopathic REM sleep behavior disorder predicts Parkinson disease

(2010) R. B. Postuma et al.   NEUROLOGY

Significance and confounders of peripheral DJ-1 and alpha-synuclein in Parkinson's disease

(2010) Min Shi et al.   NEUROSCIENCE LETTERS

DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway

(2010) H. Aleyasin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A basic smell test is as sensitive as a dopamine transporter scan: comparison of olfaction, taste and DaTSCAN in the diagnosis of Parkinson's disease

(2010) J. Deeb et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

Plasma Urate and Parkinson's Disease in the Atherosclerosis Risk in Communities (ARIC) Study

(2009) H. Chen et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications

(2009) Hong Qing et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Do parkinsonian patients have trouble telling lies? The neurobiological basis of deceptive behaviour

(2009) N. Abe et al.   BRAIN

Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease

(2009) Juliane Neumann et al.   BRAIN

Sleep disorders and daytime sleepiness in Parkinson’s disease

(2009) Renee Monderer et al.   Current Neurology and Neuroscience Reports

LRRK2 in Parkinson’s disease: genetic and clinical studies from patients

(2009) Udhaya Kumari et al.   FEBS Journal

Parkinson's disease: from monogenic forms to genetic susceptibility factors

(2009) S. Lesage et al.   HUMAN MOLECULAR GENETICS

Olfactory testing combined with dopamine transporter imaging as a method to detect prodromal Parkinson's disease

(2009) M. M Ponsen et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

The spectrum of neuropsychiatric symptoms in patients with early untreated Parkinson's disease

(2009) D Aarsland et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

The use of a color coded probability scale to interpret smell tests in suspected parkinsonism

(2009) Laura Silveira-Moriyama et al.   MOVEMENT DISORDERS

The course of depressive symptoms in early Parkinson's disease

(2009) Bernard Ravina et al.   MOVEMENT DISORDERS

Somatic mutations of the Parkinson's disease–associated gene PARK2 in glioblastoma and other human malignancies

(2009) Selvaraju Veeriah et al.   NATURE GENETICS

Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

(2009) Wataru Satake et al.   NATURE GENETICS

Can we image premotor Parkinson disease?

(2009) K. Marek et al.   NEUROLOGY

Medical records documentation of constipation preceding Parkinson disease: A case-control study

(2009) R. Savica et al.   NEUROLOGY

High-resolution diffusion tensor imaging in the substantia nigra of de novo Parkinson disease

(2009) D. E. Vaillancourt et al.   NEUROLOGY

Preparation and application of monoclonal antibodies against oxidized DJ-1. Significant elevation of oxidized DJ-1 in erythrocytes of early-stage Parkinson disease patients

(2009) Yoshiro Saito et al.   NEUROSCIENCE LETTERS

Association between GBA L444P mutation and sporadic Parkinson's disease from Mainland China

(2009) X.-Y. Mao et al.   NEUROSCIENCE LETTERS

Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease

(2009) E. Sidransky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Metabolomic Profiling in LRRK2-Related Parkinson's Disease

(2009) Krisztina K. Johansen et al.   PLoS One

Applicability of current staging/categorization of α-synuclein pathology and their clinical relevance

(2008) Laura Parkkinen et al.   ACTA NEUROPATHOLOGICA

Glucocerebrosidase Gene Mutations

(2008) Ignacio F. Mata et al.   ARCHIVES OF NEUROLOGY

Serum Urate as a Predictor of Clinical and Radiographic Progression in Parkinson Disease

(2008) Michael A. Schwarzschild   ARCHIVES OF NEUROLOGY

The Spectrum of Parkinsonian Manifestations Associated With Glucocerebrosidase Mutations

(2008) Ozlem Goker-Alpan et al.   ARCHIVES OF NEUROLOGY

Neuroimaging and transcranial ultrasonography in Parkinson’s disease

(2008) Shyamal H. Mehta et al.   Current Neurology and Neuroscience Reports

Parkinson patient fibroblasts show increased alpha-synuclein expression

(2008) Hans-Hermann Hoepken et al.   EXPERIMENTAL NEUROLOGY

Direct quantification of CSF α-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration

(2008) Brit Mollenhauer et al.   EXPERIMENTAL NEUROLOGY

Investigation of leucine-rich repeat kinase 2

(2008) Vasanti S. Anand et al.   FEBS Journal

Genomewide association study for susceptibility genes contributing to familial Parkinson disease

(2008) Nathan Pankratz et al.   HUMAN GENETICS

Gaucher disease: mutation and polymorphism spectrum in the glucocerebrosidase gene (GBA)

(2008) Kathleen S. Hruska et al.   HUMAN MUTATION

A longitudinal study of olfactory function in patients with idiopathic Parkinson's disease

(2008) B. Herting et al.   JOURNAL OF NEUROLOGY

Proteomic Analysis of Oxidative Stress-Responsive Proteins in Human Pneumocytes: Insight into the Regulation of DJ-1 Expression

(2008) Xunbao Duan et al.   JOURNAL OF PROTEOME RESEARCH

A voxel-based PET study of dopamine transporters in Parkinson's disease: Relevance of age at onset

(2008) Andrea Panzacchi et al.   NEUROBIOLOGY OF DISEASE

Biomarker discovery in neurodegenerative diseases: A proteomic approach

(2008) Min Shi et al.   NEUROBIOLOGY OF DISEASE

Midbrain iron content in early Parkinson disease: A potential biomarker of disease status

(2008) W. R. W. Martin et al.   NEUROLOGY

Cerebrospinal fluid α-synuclein in neurodegenerative disorders—A marker of synapse loss?

(2008) Annika Öhrfelt et al.   NEUROSCIENCE LETTERS

Association of olfactory dysfunction with risk for future Parkinson's disease

(2007) G. Webster Ross et al.   ANNALS OF NEUROLOGY

Functional imaging of the cerebral olfactory system in patients with Parkinson's disease

(2007) B Westermann et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Glucocerebrosidase gene mutations are associated with Parkinson's disease in southern Italy

(2007) Elvira V. De Marco et al.   MOVEMENT DISORDERS

Morphometric changes of gray matter in Parkinson's disease with depression: A voxel-based morphometry study

(2007) Adam Feldmann et al.   MOVEMENT DISORDERS

Secretion of DJ-1 into the serum of patients with Parkinson's disease

(2007) Chinatsu Maita et al.   NEUROSCIENCE LETTERS