Combining surgery and immunotherapy: turning an immunosuppressive effect into a therapeutic opportunity

Sepsis increases perioperative metastases in a murine model

(2018) Lee-Hwa Tai et al.   BMC CANCER

Neoadjuvant PD-1 Blockade in Resectable Lung Cancer

(2018) Patrick M. Forde et al.   NEW ENGLAND JOURNAL OF MEDICINE

Changes in regulatory T cells in patients with ovarian cancer undergoing surgery: Preliminary results

(2017) Meng Wu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

In situ activation of platelets with checkpoint inhibitors for post-surgical cancer immunotherapy

(2017) Chao Wang et al.   Nature Biomedical Engineering

Reducing liver metastases of colon cancer in the context of extensive and minor surgeries through β-adrenoceptors blockade and COX2 inhibition

(2016) Liat Sorski et al.   BRAIN BEHAVIOR AND IMMUNITY

Poxvirus-based active immunotherapy synergizes with CTLA-4 blockade to increase survival in a murine tumor model by improving the magnitude and quality of cytotoxic T cells

(2016) Susan P. Foy et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Propranolol Attenuates Surgical Stress–Induced Elevation of the Regulatory T Cell Response in Patients Undergoing Radical Mastectomy

(2016) Lei Zhou et al.   JOURNAL OF IMMUNOLOGY

Improved Efficacy of Neoadjuvant Compared to Adjuvant Immunotherapy to Eradicate Metastatic Disease

(2016) J. Liu et al.   Cancer Discovery

Surgical trauma induces postoperative T-cell dysfunction in lung cancer patients through the programmed death-1 pathway

(2015) Pingbo Xu et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Postoperative intra-abdominal infection and colorectal cancer recurrence: A prospective matched cohort study of inflammatory and angiogenic responses as mechanisms involved in this association

(2015) S. Alonso et al.   EJSO

Clinical research on dendritic cell vaccines to prevent postoperative recurrence and metastasis of liver cancer

(2015) T.Y. Sun et al.   GENETICS AND MOLECULAR RESEARCH

Perioperative treatment with the new synthetic TLR-4 agonist GLA-SE reduces cancer metastasis without adverse effects

(2015) Pini Matzner et al.   INTERNATIONAL JOURNAL OF CANCER

Exploiting the critical perioperative period to improve long-term cancer outcomes

(2015) Maya Horowitz et al.   Nature Reviews Clinical Oncology

Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy

(2015) A. Sivan et al.   SCIENCE

Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota

(2015) M. Vetizou et al.   SCIENCE

Postoperative Peritoneal Infection Enhances Migration and Invasion Capacities of Tumor Cells In Vitro

(2014) Silvia Salvans et al.   ANNALS OF SURGERY

Clinical Activity of Adjuvant Cytokine-Induced Killer Cell Immunotherapy in Patients with Post-Mastectomy Triple-Negative Breast Cancer

(2014) K. Pan et al.   CLINICAL CANCER RESEARCH

Multi-dose parecoxib provides an immunoprotective effect by balancing T helper 1 (Th1), Th2, Th17 and regulatory T cytokines following laparoscopy in patients with cervical cancer

(2014) WENGUANG MA et al.   Molecular Medicine Reports

Maraba MG1 Virus Enhances Natural Killer Cell Function via Conventional Dendritic Cells to Reduce Postoperative Metastatic Disease

(2014) Jiqing Zhang et al.   MOLECULAR THERAPY

Immune Monitoring of the Circulation and the Tumor Microenvironment in Patients with Regionally Advanced Melanoma Receiving Neoadjuvant Ipilimumab

(2014) Ahmad A. Tarhini et al.   PLoS One

Autologous Tumor Lysate-Pulsed Dendritic Cell Immunotherapy with Cytokine-Induced Killer Cells Improves Survival in Gastric and Colorectal Cancer Patients

(2014) Daiqing Gao et al.   PLoS One

The Central Role of Arginine Catabolism in T-Cell Dysfunction and Increased Susceptibility to Infection After Physical Injury

(2013) Xinmei Zhu et al.   ANNALS OF SURGERY

Delivery of viral-vectored vaccines by B cells represents a novel strategy to accelerate CD8+ T-cell recall responses

(2013) L. Zhang et al.   BLOOD

In vivo suppression of NK cell cytotoxicity by stress and surgery: Glucocorticoids have a minor role compared to catecholamines and prostaglandins

(2013) Ella Rosenne et al.   BRAIN BEHAVIOR AND IMMUNITY

TLR agonists: our best frenemy in cancer immunotherapy

(2013) Sabina Kaczanowska et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Maraba Virus as a Potent Oncolytic Vaccine Vector

(2013) Jonathan G Pol et al.   MOLECULAR THERAPY

Surgical Stress Promotes the Development of Cancer Metastases by a Coagulation-Dependent Mechanism Involving Natural Killer Cells in a Murine Model

(2012) Rashmi Seth et al.   ANNALS OF SURGERY

Preventing Postoperative Metastatic Disease by Inhibiting Surgery-Induced Dysfunction in Natural Killer Cells

(2012) L.-H. Tai et al.   CANCER RESEARCH

Trauma equals danger--damage control by the immune system

(2012) V. M. Stoecklein et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Intraoperative Hypothermia During Cytoreductive Surgery for Ovarian Cancer and Perioperative Morbidity

(2012) Mehdi Moslemi-Kebria et al.   OBSTETRICS AND GYNECOLOGY

Improving Postoperative Immune Status and Resistance to Cancer Metastasis

(2011) Yael Goldfarb et al.   ANNALS OF SURGERY

Increased Local Recurrence and Reduced Survival From Colorectal Cancer Following Anastomotic Leak

(2011) Alexander Mirnezami et al.   ANNALS OF SURGERY

The Impact of Anastomotic Leak and Intra-Abdominal Abscess on Cancer-Related Outcomes After Resection for Colorectal Cancer

(2011) Joshua M. Eberhardt et al.   DISEASES OF THE COLON & RECTUM

Precise Scheduling of Chemotherapy Primes VEGF-producing Tumors for Successful Systemic Oncolytic Virotherapy

(2011) Timothy Kottke et al.   MOLECULAR THERAPY

The Role of the Perioperative Period in Recurrence After Cancer Surgery

(2010) Antje Gottschalk et al.   ANESTHESIA AND ANALGESIA

The expression of activating natural killer cell receptors in patients with primary breast cancer.

(2010) CR Carter et al.   CANCER RESEARCH

Preoperative CTLA-4 Blockade: Tolerability and Immune Monitoring in the Setting of a Presurgical Clinical Trial

(2010) B. C. Carthon et al.   CLINICAL CANCER RESEARCH

Improving Survival Rates in Two Models of Spontaneous Postoperative Metastasis in Mice by Combined Administration of a β-Adrenergic Antagonist and a Cyclooxygenase-2 Inhibitor

(2010) Ariella Glasner et al.   JOURNAL OF IMMUNOLOGY

Potentiating Cancer Immunotherapy Using an Oncolytic Virus

(2010) Byram W Bridle et al.   MOLECULAR THERAPY

Postoperative Complications After Transthoracic Esophagectomy for Cancer of the Esophagus and Gastroesophageal Junction Are Correlated With Early Cancer Recurrence

(2009) Toni Lerut et al.   ANNALS OF SURGERY

The Perioperative Period is an Underutilized Window of Therapeutic Opportunity in Patients With Colorectal Cancer

(2009) Gerben J. van der Bij et al.   ANNALS OF SURGERY

Immune perturbations in patients along the perioperative period: Alterations in cell surface markers and leukocyte subtypes before and after surgery

(2009) Inbal Bartal et al.   BRAIN BEHAVIOR AND IMMUNITY

Reciprocal Human Dendritic Cell-Natural Killer Cell Interactions Induce Antitumor Activity Following Tumor Cell Infection by Oncolytic Reovirus

(2009) R. J. Prestwich et al.   JOURNAL OF IMMUNOLOGY

CpG-C Oligodeoxynucleotides Limit the Deleterious Effects of β-adrenoceptor Stimulation on NK Cytotoxicity and Metastatic Dissemination

(2009) Yael Goldfarb et al.   JOURNAL OF IMMUNOTHERAPY

Activation of Natural Killer Cells by Newcastle Disease Virus Hemagglutinin-Neuraminidase

(2009) M. Jarahian et al.   JOURNAL OF VIROLOGY

Perioperative Use of β-blockers and COX-2 Inhibitors May Improve Immune Competence and Reduce the Risk of Tumor Metastasis

(2008) Marganit Benish et al.   ANNALS OF SURGICAL ONCOLOGY

Metastatic-promoting effects of LPS: Sexual dimorphism and mediation by catecholamines and prostaglandins

(2008) Ranit Naor et al.   BRAIN BEHAVIOR AND IMMUNITY

Phase Ib Trial of Mutant Herpes Simplex Virus G207 Inoculated Pre-and Post-tumor Resection for Recurrent GBM

(2008) James M Markert et al.   MOLECULAR THERAPY

Pretreatment with Interferon-a2a Modulates Perioperative Immunodysfunction in Patients with Renal Cell Carcinoma

(2008) Tobias Klatte et al.   ONKOLOGIE