The adjuvant GLA-AF enhances human intradermal vaccine responses

Langerhans Cells Orchestrate T FH -Dependent Humoral Immunity

(2017) Trupti Vardam et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Critical Role for Skin-Derived Migratory DCs and Langerhans Cells in T FH and GC Responses after Intradermal Immunization

(2017) Clément Levin et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Transdermal delivery of vaccines – Recent progress and critical issues

(2016) Kevin Ita   BIOMEDICINE & PHARMACOTHERAPY

A plant-derived quadrivalent virus like particle influenza vaccine induces cross-reactive antibody and T cell response in healthy adults

(2016) Stéphane Pillet et al.   CLINICAL IMMUNOLOGY

Immune response and reactogenicity of intradermal administration versus subcutaneous administration of varicella-zoster virus vaccine: an exploratory, randomised, partly blinded trial

(2016) Chan R Beals et al.   LANCET INFECTIOUS DISEASES

A phase 1, open-label, randomized study to compare the immunogenicity and safety of different administration routes and doses of virosomal influenza vaccine in elderly

(2016) Yotam Levin et al.   VACCINE

Schistosomiasis vaccine candidate Sm14/GLA-SE: Phase 1 safety and immunogenicity clinical trial in healthy, male adults

(2016) Marilia Santini-Oliveira et al.   VACCINE

Synthetic TLR4 agonists enhance functional antibodies and CD4+ T-cell responses against the Plasmodium falciparum GMZ2.6C multi-stage vaccine antigen

(2016) Susan L. Baldwin et al.   VACCINE

Alum: an old dog with new tricks

(2016) Yumei Wen et al.   Emerging Microbes & Infections

The stimulatory effect of the TLR4-mediated adjuvant glucopyranosyl lipid A is well preserved in old age

(2015) Birgit Weinberger et al.   BIOGERONTOLOGY

A review of the changes to the licensing of influenza vaccines in Europe

(2015) Leonoor Wijnans et al.   Influenza and Other Respiratory Viruses

The EMBL-EBI bioinformatics web and programmatic tools framework

(2015) Weizhong Li et al.   NUCLEIC ACIDS RESEARCH

Intradermal vaccination using the novel microneedle device MicronJet600: Past, present, and future

(2015) Yotam Levin et al.   Human Vaccines & Immunotherapeutics

Advances in aluminum hydroxide-based adjuvant research and its mechanism

(2015) Peng He et al.   Human Vaccines & Immunotherapeutics

Influenza virus-like particle vaccines made in Nicotiana benthamiana elicit durable, poly-functional and cross-reactive T cell responses to influenza HA antigens

(2014) Nathalie Landry et al.   CLINICAL IMMUNOLOGY

Cutaneous immunization: an evolving paradigm in influenza vaccines

(2014) Harvinder S Gill et al.   Expert Opinion on Drug Delivery

Clinical Adjuvant Combinations Stimulate Potent B-Cell Responses In Vitro by Activating Dermal Dendritic Cells

(2013) Katie Matthews et al.   PLoS One

Effect of natural and chimeric haemagglutinin genes on influenza A virus replication in baby hamster kidney cells

(2012) R. van Wielink et al.   JOURNAL OF BIOTECHNOLOGY

Toward Animal Cell Culture-Based Influenza Vaccine Design: Viral Hemagglutinin N-Glycosylation Markedly Impacts Immunogenicity

(2012) J. Hutter et al.   JOURNAL OF IMMUNOLOGY

Glucopyranosyl Lipid Adjuvant (GLA), a Synthetic TLR4 Agonist, Promotes Potent Systemic and Mucosal Responses to Intranasal Immunization with HIVgp140

(2012) Mauricio A. Arias et al.   PLoS One

Toll-like receptor modulators: a patent review (2006 – 2010)

(2011) Shaherin Basith et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Vaccine adjuvants: The dream becomes real

(2011) Aldo Tagliabue et al.   Human vaccines & immunotherapeutics

A plant-based system for rapid production of influenza vaccine antigens

(2011) Yoko Shoji et al.   Influenza and Other Respiratory Viruses

GLA-SE, a Synthetic Toll-like Receptor 4 Agonist, Enhances T-Cell Responses to Influenza Vaccine in Older Adults

(2011) Hayedeh Behzad et al.   JOURNAL OF INFECTIOUS DISEASES

Programming the magnitude and persistence of antibody responses with innate immunity

(2011) Sudhir Pai Kasturi et al.   NATURE

Targeting TLRs Expands the Antibody Repertoire in Response to a Malaria Vaccine

(2011) S. R. Wiley et al.   Science Translational Medicine

Recombinant HA1 produced in E. coli forms functional oligomers and generates strain-specific SRID potency antibodies for pandemic influenza vaccines

(2011) Surender Khurana et al.   VACCINE

Evaluation of the safety, reactogenicity and immunogenicity of FluBlok® trivalent recombinant baculovirus-expressed hemagglutinin influenza vaccine administered intramuscularly to healthy adults 50–64 years of age☆

(2011) R. Baxter et al.   VACCINE

The production of hemagglutinin-based virus-like particles in plants: a rapid, efficient and safe response to pandemic influenza

(2010) Marc-André D’Aoust et al.   PLANT BIOTECHNOLOGY JOURNAL

Preclinical and Clinical Development of Plant-Made Virus-Like Particle Vaccine against Avian H5N1 Influenza

(2010) Nathalie Landry et al.   PLoS One

Role of adjuvants in modeling the immune response

(2010) Darrick Carter et al.   Current Opinion in HIV and AIDS

Enhanced humoral and Type 1 cellular immune responses with Fluzone® adjuvanted with a synthetic TLR4 agonist formulated in an emulsion

(2009) Susan L. Baldwin et al.   VACCINE

Influenza virus-like particles produced by transient expression inNicotiana benthamianainduce a protective immune response against a lethal viral challenge in mice

(2008) Marc-André D’Aoust et al.   PLANT BIOTECHNOLOGY JOURNAL