Editorial Material
Biochemistry & Molecular Biology
Melissa Emery Thompson
Summary: In species with intense male competition, females delay or accelerate puberty to moderate the risks of inbreeding and infanticide, according to a new study of wild gelada monkeys.
Editorial Material
Urology & Nephrology
Peter Sohn, Yoko Narasaki, Connie M. Rhee
Summary: This study by Keane et al. provides new data on the incidence of IDH over specific time intervals during hemodialysis treatment session, clinical parameters associated with the timing of IDH onset, and whether timing of IDH impacts survival in a nationally representative hemodialysis cohort.
KIDNEY INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Ake Lernmark
Summary: Life is all about timing, as understanding autoimmune type 1 diabetes requires attention to the timing of events. The strong association with HLA has been researched for nearly 50 years. Clarifying the etiology of type 1 diabetes necessitates consideration of the timing of events before the first-appearing islet autoantibody.
Editorial Material
Biochemistry & Molecular Biology
Thomas Davies, Kevin G. Hardwick
Summary: Bub1 and Polo kinases, known multitasking regulators, collaborate at kinetochores to determine mitotic duration in nematode embryonic divisions. Cdc20 activity plays a crucial role in this process.
Article
Clinical Neurology
Matthew Weightman, John-Stuart Brittain, Alison Hall, R. Chris Miall, Ned Jenkinson
Summary: The study found that short-duration stimulation applied to the cerebellum enhanced movements performed simultaneously with stimulation, while M1 stimulation did not improve adaptation. This suggests that the coupling of cerebellar stimulation and movement plays a crucial role in facilitating enhanced learning in the stimulated context.
Article
Surgery
Nina Devas, Andrew Guenthart, Lizhou Nie, Isha Joshi, Jie Yang, Gareth Morris-Stiff, Aurora Pryor
Summary: This study investigates the outcomes of delayed cholecystectomy and finds that performing the surgery within 3-4 days after presentation is associated with fewer complications, readmissions, emergency department visits, and reduced length of hospital stay.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Review
Oncology
Emily J. Lelliott, Karen E. Sheppard, Grant A. McArthur
Summary: CDK4/6 inhibitors have shown both tumor-intrinsic cytostatic potential and profound immunomodulatory activity in recent studies. They have significant implications for melanoma therapies, as melanoma is a highly immunogenic cancer. However, the immunomodulatory effects of CDK4/6 inhibitors may have both positive and negative impacts on anti-tumor immunity.
NPJ PRECISION ONCOLOGY
(2022)
Article
Plant Sciences
Henrik Svennerstam, Sandra Jamtgard
Summary: This study compared two established methods for determining plant amino acid uptake. The results showed that time is a crucial factor in determining plant amino acid uptake. Post-uptake metabolism in plants may result in significant carbon loss, indicating that both pre-uptake metabolism by microbes and post-uptake metabolism in plants contribute to the reported N-15-C-13 mismatch in ecological studies.
Article
Economics
Brantley Liddle
Summary: In this article, the reasons and hypotheses for the variations in GDP and price elasticities of energy/electricity demand over time are assessed, along with the evidence from relevant research papers. Parametric and semi- or non-parametric approaches have been adopted in these papers. While events like energy price shocks and country-specific circumstances may cause variations in GDP and price elasticities, the weight of evidence suggests that income/GDP and price elasticities of energy/electricity demand are relatively stable over time. The exception is the decline in GDP elasticity of economy-wide electricity demand in OECD countries, which is possibly due to the saturation of energy services provided by electricity. Modelers are recommended to use a combination of parametric and nonparametric approaches and strive for consensus among results.
Review
Endocrinology & Metabolism
Seithikurippu R. Pandi-Perumal, Daniel P. Cardinali, Nevin F. W. Zaki, Ramanujam Karthikeyan, David Warren Spence, Russel J. Reiter, Gregory M. Brown
Summary: Sleep and the circadian clock are interconnected and vital to human health and well-being. The suprachiasmatic nucleus controls the sleep-wake cycle and homeostatic activities. Melatonin, as a part of the endogenous circadian clock, plays a critical role in sleep regulation. Light acts as a signal for sleep/wake control by affecting melatonin secretion. Clock genes serve as molecular timekeepers for maintaining the 24-hour cycle. The significance of these processes has been officially recognized in modern sleep and behavioral disorder diagnostic manuals. Timing in the brain is crucial for optimal brain physiology.
FRONTIERS IN NEUROENDOCRINOLOGY
(2022)
Article
Surgery
Jesse A. Codner, Ryan H. Archer, Grant C. Lynde, Jyotirmay Sharma
Summary: This study aimed to compare surgical outcomes between SARS-CoV-2 positive and negative surgical patients and found that the timing of SARS-CoV-2 positivity before surgery has an impact on major complications. The study results suggest that in certain cases, surgery should be postponed 14 days after SARS-CoV-2 positivity.
WORLD JOURNAL OF SURGERY
(2023)
Article
Ecology
Patrick J. Hart, Thomas Ibanez, Kristina Paxton, Grace Tredinnick, Esther Sebastian-Gonzalez, Ann Tanimoto-Johnson
Summary: The study found a high degree of signal overlap in the bird communities of Costa Rica and Hawai'i, but species significantly reduced this overlap through temporal partitioning, supporting the acoustic niche hypothesis. There was little support for acoustic clustering or species segregating based on vocalization frequency range, suggesting competition for acoustic space primarily results in temporal partitioning.
FRONTIERS IN ECOLOGY AND EVOLUTION
(2021)
Review
Clinical Neurology
Dylan Goehner, Sandeep Kandregula, Harjus Birk, Christopher P. Carroll, Bharat Guthikonda, Jennifer A. Kosty
Summary: Postoperative telephone calls can increase patient satisfaction and potentially improve safety and outcomes.
NEUROSURGICAL FOCUS
(2021)
Article
Plant Sciences
Vincent Philion, Valentin Joubert, Marc Trapman, Arne Stensvand
Summary: This study investigated the efficacy of available fungicides against apple scab caused by Venturia inaequalis. It was found that sprays applied during the spore germination phase showed the best efficacy, followed by applications ahead of inoculation. Some products also showed good efficacy in early infection, while efficacy dropped in late infection. Sprays applied on the abaxial leaf surface also showed some efficacy. The study also revealed a close relationship between the EC50 of active ingredients on potted trees and the label rate, which can help improve spraying decisions and reduce costs.
Review
Clinical Neurology
Daniel Williamson, Edward C. Schwalbe, Simon Bailey, Steven C. Clifford
Summary: Childhood brain tumour medulloblastoma can be classified into multiple molecular subgroups based on DNA methylation and expression patterns. Recent studies have shown a continuous association between survival outcome, the transcriptional profile of a Group3/Group4 medulloblastoma, and the specific point during early fetal cerebellar development at which initial pathogenic disruption occurred. This finding suggests that using expression biomarkers for continuous risk prediction may offer a more effective stratification of patients with Group3/Group4 medulloblastoma, instead of relying on discrete DNA methylation subgroups.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2023)