Article
Cardiac & Cardiovascular Systems
Zhen Meng, Zhe Li, Erli Zhang, Li Zhang, Qingrong Liu, Yongjian Wu
Summary: The study demonstrates that sevelamer treatment can alleviate calcification of bioprosthetic heart valves and has anti-inflammatory effects. These effects are independent of serum calcium and phosphate regulation and may help prolong the longevity of bioprosthetic heart valves.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
David Meier, Geoffrey W. Payne, Leila B. Mostaco-Guidolin, Rihab Bouchareb, Courtney Rich, Althea Lai, Andrew G. Chatfield, Mariama Akodad, Hannah Salcudean, Georg Lutter, Thomas Puehler, Philippe Pibarot, Keith B. Allen, Adnan K. Chhatriwalla, Lars Sondergaard, David A. Wood, John G. Webb, Jonathon A. Leipsic, Janarthanan Sathananthan, Stephanie L. Sellers
Summary: This study assessed the impact of the timing of bioprosthetic valve fracture on the durability of transcatheter heart valve replacement. The results showed that valve fracture performed after the procedure could provide better long-term effective orifice area without increased regurgitant fraction.
Article
Materials Science, Multidisciplinary
Soumen Jana, Federico Franchi, Amir Lerman
Summary: The study developed trilayered microfibrous leaflet substrates using electrospinning to mimic native heart valve leaflets, which were implanted in rats to study their effect on in vivo tissue engineering. The resulting tissue constructs showed well-defined structure and anisotropic tensile properties suitable for withstanding physiological loads, indicating potential for heart valve replacements.
APPLIED MATERIALS TODAY
(2021)
Review
Pharmacology & Pharmacy
Shuyu Wen, Ying Zhou, Wai Yen Yim, Shijie Wang, Li Xu, Jiawei Shi, Weihua Qiao, Nianguo Dong
Summary: Valve replacement is the main therapy for valvular heart disease, with bioprosthetic heart valves (BHV) surpassing mechanical heart valves (MHV) as the leading option due to their excellent properties. However, BHV is prone to structural valve degeneration (SVD) primarily caused by calcification. Understanding the basic mechanisms of calcification is essential for addressing the limited durability of BHV.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Hoda Javadikasgari, Raphaelle A. Chemtob, A. Marc Gillinov, Gosta B. Pettersson, Ashley M. Lowry, Milind Y. Desai, Lars G. Svensson, Eugene H. Blackstone, Per Wierup
Summary: This study evaluated the outcomes and long-term survival of patients with bioprosthetic mitral valve deterioration who underwent surgical mitral valve re-replacement. It was found that isolated mitral valve re-replacement had low surgical risk and excellent long-term survival. Excessive cardiopulmonary bypass duration and multiple transfusions were associated with increased early mortality in nonisolated procedures.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Review
Cardiac & Cardiovascular Systems
Matteo Marro, Alexander P. Kossar, Yingfei Xue, Antonio Frasca, Robert J. Levy, Giovanni Ferrari
Summary: Bioprosthetic heart valves (BHVs) offer an alternative to mechanical valves with reduced long-term anticoagulation needs, but are prone to structural valve degeneration which may require reoperation. This degeneration, often characterized by leaflet calcification, can also occur with minimal mineralization in some cases, posing challenges for treatment. Various factors such as protein infiltration, glycation, oxidative and mechanical stress, and inflammation may play a role in noncalcific mechanisms of BHV structural valve degeneration.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Computer Science, Interdisciplinary Applications
Jing Hu, Hongwei Wu, Xiaoqiang Gu, Qihui Zhou
Summary: Particle shape is an important factor affecting the mechanical properties of granular soils. The discrete element method (DEM) allows for the investigation of particle shape effects on the dynamic properties of granular soils. Experimental results show that specimens consisting of angular particles generally have a higher secant shear modulus G compared to rounded particles. Particle shape has no significant effect on modulus ratio G/G0 but noticeably impacts the damping ratio D at relatively large strains. The use of a weighted coordination number CN' reveals the microscopic effect of particle shape on the initial modulus G0. The tangential shear modulus ratio Gtan/G0 is inversely correlated to the weighted contact sliding ratio fs'.
COMPUTERS AND GEOTECHNICS
(2023)
Article
Multidisciplinary Sciences
Alexey Abramov, Yingfei Xue, Andrey Zakharchenko, Mangesh Kurade, Rajesh K. Soni, Robert J. Levy, Giovanni Ferrari
Summary: A study found that metabolic syndrome is a risk factor for heart valve degeneration, and patients with metabolic syndrome require valve replacement earlier. The study used advanced proteomics to identify significant differences in the protein composition of heart valves between patients with and without metabolic syndrome. Furthermore, the study demonstrated that a protective modification can mitigate the degeneration of heart valve biomaterial caused by metabolic syndrome.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Medicine, General & Internal
Carlos Munoz, Carla Valencia, Christopher Scoma, Joel Fernandez
Summary: Early bioprosthetic valve failure can result in severe mitral regurgitation, but transcatheter valve replacement can be an effective treatment option.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Cardiac & Cardiovascular Systems
Yingfei Xue, Alexander P. Kossar, Alexey Abramov, Antonio Frasca, Mingze Sun, Mariya Zyablitskaya, David Paik, David Kalfa, Mila Della Barbera, Gaetano Thiene, Satoshi Kozaki, Takayuki Kawashima, Joseph H. Gorman III, Robert C. Gorman, Matthew J. Gillespie, Chrystalle Katte Carreon, Stephen P. Sanders, Robert J. Levy, Giovanni Ferrari
Summary: This study investigates the mechanisms of structural valve degeneration in young patients and juvenile animals with bioprosthetic heart valves, and presents models for studying this phenomenon.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Barbara Wichert-Schmitt, Jasmine Grewal, A. Kinga Malinowski, Birgit Pfaller, Katie L. Losenno, Marla C. Kiess, Jack M. Colman, Wendy Tsang, Jennifer Mason, Samuel C. Siu, Candice K. Silversides
Summary: This study examined the outcomes of pregnant women with bioprosthetic valves (BPVs) and the association with structural valve dysfunction (SVD). The results showed that SVD negatively affected pregnancy outcomes, particularly in cases of left-sided BPV.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Biophysics
Alp Karakoc, Olcay Aksoy, Ertugrul Taciroglu
Summary: By parameterizing the heart valve and studying the crimping procedure, it was found that the compression process inevitably generates stress, which negatively affects the durability of the valve.
JOURNAL OF BIOMECHANICS
(2023)
Article
Cardiac & Cardiovascular Systems
Bastien Poitier, Jeanne Rancic, Ulysse Richez, Julie Piquet, Salma El Batti, David M. M. Smadja
Summary: This study aimed to investigate whether fibrin deposition could lead to calcification in bovine pericardium tissue. The results showed that fibrin-treated tissue had higher levels of calcification and more inflammatory-like cell infiltration. The conclusion is that fibrin deposition may be one of the triggers for calcification and deterioration of heart valves.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Jannis Hagenah, Michael Scharfschwerdt, Floris Ernst
Summary: Despite advances in medical imaging, there are certain structures in the human body that are difficult to assess using conventional imaging methods. This study presents a new framework for bridging the domain gap in estimating anatomical shapes based on surrounding tissue's morphology. Through deep representation learning and domain mapping, the study demonstrates the ability to predict the shape of inaccessible structures solely based on information from surrounding tissue, even with limited data.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Engineering, Biomedical
David Oks, Cristobal Samaniego, Guillaume Houzeaux, Constantine Butakoff, Mariano Vazquez
Summary: This study used a computational model to analyze the impact of aortic annulus eccentricity and leaflet rigidity on bioprosthetic aortic valve replacements (BAVRs), highlighting their significant effects on valve performance, thrombogenic risk, and calcification risk.
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING
(2022)