Article
Materials Science, Multidisciplinary
Yuwei Qiu, Kunlun Jiang, Jingrui Wu, Hua Mi, Yung-Kang Peng, Yun Young Go, Hyun June Park, Jung-Hoon Lee
Summary: The PPT-iPCR assay method introduced in this study reduces the required thermal cycling time for amplification without compromising sensitivity, using plasmonic magnetic nanoparticles and LED devices. It is capable of sensitive and quantitative protein detection, and can be easily combined with mobile phones or micro-optics for the development of inexpensive and highly mobile detection devices.
APPLIED MATERIALS TODAY
(2021)
Article
Clinical Neurology
Rosa Cortese, Luca Prosperini, Alessandro Stasolla, Shalom Haggiag, Veronica Villani, Isabella Laura Simone, Claudio Gasperini, Carla Tortorella
Summary: This study described 8 patients who experienced demyelinating CNS events while on anti-TNF alpha treatment, with most patients showing a good medium-term prognosis. The results support an association between anti-TNF alpha treatment and demyelinating events, and suggest that prompt discontinuation of the drug may lead to a favorable demyelinating disease outcome.
JOURNAL OF NEUROLOGY
(2021)
Article
Immunology
Ming-Han Chen, Shan-Fu Yu, Jia-Feng Chen, Wei-Sheng Chen, The-Ling Liou, Chung-Tei Chou, Chung-Yuan Hsu, Han-Ming Lai, Ying-Chou Chen, Chang-Youh Tsai, Tien-Tsai Cheng
Summary: The study compared the impact of different treatment regimens for rheumatoid arthritis on patients' bone mineral density, finding that abatacept may have a better effect in preserving bone density. Anti-osteoporosis therapy can prevent systemic bone loss in patients regardless of the type of rheumatoid arthritis treatment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Lin Feng, Yinan Ma
Summary: The consumption of a high-fat diet increases TNF-alpha levels in the spleen of rats, along with upregulation of TLR4 and NF-kappa B mRNAs and downregulation of alpha 7nAChR mRNA expression in splenic macrophages. Exercise intervention can counteract the detrimental effects of HFD on TNF-alpha levels in the spleen and prevent the abnormal expression of these genes in rat spleen macrophages.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Dermatology
Hidehisa Saeki, Tomotaka Mabuchi, Akihiko Asahina, Masatoshi Abe, Atsuyuki Igarashi, Shinichi Imafuku, Yukari Okubo, Mayumi Komine, Shigetoshi Sano, Hideshi Torii, Akimichi Morita, Hiroshi Yotsuyanagi, Akira Watanabe, Mamitaro Ohtsuki
Summary: This article provides an overview of the development of biologics for psoriasis treatment in Japan and emphasizes the importance of considering factors such as efficacy, safety, convenience, and cost when selecting biologic therapies for patients.
JOURNAL OF DERMATOLOGY
(2022)
Article
Oncology
Joon Min Jung, Ye-Jee Kim, Sung Eun Chang, Mi Woo Lee, Chong Hyun Won, Woo Jin Lee
Summary: This study aimed to assess the cancer risks in patients with psoriasis and evaluate the impact of TNF-α inhibitor and IL-12/23 inhibitor therapy on these risks. The results showed that patients with psoriasis had a significantly higher overall cancer risk compared to the general population. TNF-α inhibitor therapy was associated with an increased risk of overall cancer and lymphoma, while IL-12/23 inhibitor therapy was not associated with an increased risk of any cancer.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Dentistry, Oral Surgery & Medicine
Dan Liu, Tianyu Zhang, Hangfan Zhou, Yang Meng, Chuanji Wu, Yutong Sun, Yiming Xu, Xiaoting Deng, Hui Wang, Lu Jiang
Summary: Refractory recurrent aphthous stomatitis (RRAS) is a disease characterized by severe ulcerative lesions of the oral mucosa that do not respond well to conventional therapy. Biologics have emerged as a promising targeted therapy for RRAS, offering a more precise and hopeful treatment approach.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2022)
Article
Medicine, Research & Experimental
Yunqian Guan, Ren Wang, Xiaobo Li, Haiqiang Zou, Wenxiu Yu, Zhaohui Liang, Lei Li, Ling Chen, Liping Zhou, Zhiguo Chen
Summary: The study found that astrocytes, not microglia, were the main source of TNF-alpha expression in the infarct area of rats after ischemia. MSC transplantation was shown to suppress TNF-alpha expression by astrocytes.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Luigi Brunetti, Helene Chapy, Ronald G. G. Nahass, Rebecca Moore, Andrew Wassef, Derek Adler, Edward Yurkow, Leonid Kagan
Summary: The effect of obesity on IgG pharmacokinetics was investigated in a rat model and clinical evidence for an association between body composition and IVIG pharmacokinetic parameters in humans was collected. The pharmacokinetics of human IgG was significantly different between obese and lean rats. In the clinical study, total serum IgG concentration and subtype half-life negatively correlated with BMI and fat mass.
Article
Medicine, General & Internal
Teppei Hagino, Hidehisa Saeki, Eita Fujimoto, Naoko Kanda
Summary: Psoriasis is linked to cardiometabolic and cardiovascular diseases. Biologic therapy targeting TNF-alpha, IL-23, and IL-17 can improve both psoriasis and cardiometabolic diseases. A retrospective evaluation was conducted to assess the effect of biologic therapy on various indicators of cardiometabolic disease.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Immunology
Anais Makos, J. H. Kuiper, O. Kehoe, R. Amarasena
Summary: Psoriatic arthritis is a chronic and painful inflammatory immune-mediated disease. This study aimed to identify potential biomarkers for predicting treatment response and guiding biologic drug therapy.
INFLAMMOPHARMACOLOGY
(2023)
Review
Virology
Parisa Moradimajd, Hamidreza Samaee, Shahnam Sedigh-Maroufi, Masoumeh Kourosh-Aami, Monireh Mohsenzadagan
Summary: Since the end of 2019, a special pneumonia associated with a novel coronavirus named 2019-nCoV has been reported in Wuhan, China. Currently, there is no definitive treatment for coronavirus disease-19 (COVID-19) infection, and drugs introduced are still in the clinical trial phase.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Dermatology
Benjamin Lockshin, Angel Cronin, Ryan W. Harrison, Robert R. McLean, Laura Anatale-Tardiff, Russel Burge, Baojin Zhu, William N. Malatestinic, Bilal Atiya, Mwangi J. Murage, Gaia Gallo, Bruce Strober, Abby Van Voorhees
Summary: In a study of real-world patients with psoriasis, initiators of ixekizumab had longer drug survival compared to initiators of TNF inhibitors and other IL-17 inhibitors, with persistence up to 2 years of follow-up.
DERMATOLOGIC THERAPY
(2021)
Article
Rheumatology
Bente Glintborg, Daniela Di Giuseppe, Johan Karlsson Wallman, Dan C. Nordstrom, Bjorn Gudbjornsson, Merete Lund Hetland, Johan Askling, Gerdur Grondal, Tuulikki Sokka, Sella A. Provan, Brigitte Michelsen, Eirik Klami Kristianslund, Lene Dreyer, Thorvardur Jon Love, Ulf Lindstrom
Summary: This study aimed to describe the uptake and effectiveness of newer biologic or targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) in psoriatic arthritis (PsA) in the Nordic countries. The results showed that the uptake of newer b/tsDMARDs increased from 2014 and plateaued in 2018. Regardless of treatment course, only a minority of patients starting a second or later b/tsDMARD course remained on drug and achieved low disease activity (LDA).
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Hanzhe Zhang, Jiajun Wen, G. Caleb Alexander, Jeffrey R. Curtis
Summary: The study found that TNF-alpha inhibitors appeared to be more effective than IL-12/23 antagonists for biologic-naive individuals and PDE4 inhibitors for biologic-experienced individuals with Psoriatic Arthritis. This information may help guide treatment decisions for individuals with PsA.
Article
Dermatology
Kabir Sardana, Sinu Rose Mathachan, Desh Deepak, Ananta Khurana, Surabhi Sinha
Summary: This article reports cases of palmoplantar among health care workers on prophylactic doses of hydroxychloroquine and discusses their management with cetirizine and methylprednisolone.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2022)
Article
Dermatology
Soumya Sachdeva, Ananta Khurana, Parul Goyal, Kabir Sardana
Summary: The study compared oxidative stress parameters in patients with alopecia areata and healthy controls, finding that patients had lower levels of TAS and SOD, and higher levels of MDA. The levels of TAS and SOD decreased with disease severity, while MDA levels increased.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Letter
Dermatology
Sinu Rose Mathachan, Kabir Sardana, Ananta Khurana
DERMATOLOGIC THERAPY
(2022)
Article
Dermatology
Savitha Bathula, Kabir Sardana, Sinu Rose Mathachan, Ananta Khurana, Arvind Ahuja, Purnima Paliwal
Summary: Background Corticosteroids are the main therapy for erythema nodosum leprosum (ENL), but long-term usage can cause significant morbidity and mortality. Thalidomide has a dramatic effect in controlling ENL and helps reduce the dose of steroids, but cost is a hindrance to its usage.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
Ananta Khurana, B. Savitha
Summary: ALHE is a rare benign vascular proliferative condition that usually occurs in the head and neck area, particularly near the ear, presenting as painless vascular papules or nodules. We report a case of ALHE that failed multiple therapeutic interventions but achieved complete resolution when treated with thalidomide.
PEDIATRIC DERMATOLOGY
(2022)
Letter
Mycology
Ananta Khurana, Aastha Agarwal, Diksha Agrawal, Kabir Sardana, Ashutosh Singh, Anuradha Chowdhary
Summary: Due to increasing drug resistance and erratic clinical responses, treatment options for refractory dermatophytosis are limited. However, refractory dermatophytosis has become a significant public health issue in India in recent years. This article presents a patient who failed four systemic antifungals sequentially but was cured with a 2-week course of voriconazole, an antifungal not commonly used for dermatophytosis.
JOURNAL DE MYCOLOGIE MEDICALE
(2022)
Letter
Dermatology
Aishwarya Muddebihal, Kabir Sardana, Ananta Khurana, Soumya Sachdeva, Itu Singh, Madhvi Ahuja, Rahul Sharma
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Microbiology
Anuradha Chowdhary, Ashutosh Singh, Amtoj Kaur, Ananta Khurana
Article
Dermatology
Ananta Khurana, Aastha Agarwal, Diksha Agrawal, Sanjeet Panesar, Manik Ghadlinge, Kabir Sardana, Khushboo Sethia, Shalini Malhotra, Ankit Chauhan, Nirmala Mehta
Summary: This randomized clinical trial compares the efficacy and safety of different doses of itraconazole for the treatment of tinea corporis/cruris. The study found that the 400 mg dose was superior to the 100 mg and 200 mg doses in terms of cure rates and treatment duration. However, higher doses of treatment incurred higher costs.
Article
Dermatology
Anamika Bhattacharyya, Suresh Sadhasivam, Mau Sinha, Swati Gupta, Swamini Saini, Himanshi Singh, Ananta Khurana, Soumya Sachdeva, Kabir Sardana, Shamik Ghosh
Summary: This study conducted a proteomic and genomic analysis on isolates from therapeutically recalcitrant cases of dermatophyte infections. The findings revealed gene mutations and enzymatic abnormalities that may explain the failures of antifungal treatment. Multiple gene mutations were identified in the resistant strains, including those predicting resistance to terbinafine and azole drugs, as well as efflux pumps associated with multidrug resistance.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2023)
Review
Pharmacology & Pharmacy
Aishwarya Muddebihal, Ananta Khurana, Kabir Sardana
Summary: JAK inhibitors have shown promising results in treating various cutaneous disorders, especially refractory conditions. However, the clinical use of JAK inhibitors in dermatology is mainly based on robust evidence for some conditions, while for others it relies on anecdotal evidence.
EXPERT REVIEW OF CLINICAL PHARMACOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Aishwarya Muddebihal, Kabir Sardana, Ananta Khurana, Arvind Ahuja, Itu Singh
Summary: The study found that infections and pregnancy were the most common triggers for leprosy reactions, with triggers being more common in the type 2 reaction group. The study also revealed that the cost of investigations was higher in the reactional group, but extensive investigations were not justified unless there was a clear infective trigger.
Letter
Dermatology
Ananta Khurana, Ritu Kumari, Karthik Lakshmanan, Piyush Jain, Sumitra Meena
INDIAN JOURNAL OF DERMATOLOGY
(2023)
Letter
Dermatology
Sweta Singh, Ananta Khurana, Anubhuti Chitkara
Summary: This study analyzed the role of interleukins (ILs) 6, 8, 17, and 22 in the pathogenesis of acne. Serum levels of IL-6, IL-8, IL-17, and IL-22 were measured and correlated with the severity of acne. The results showed that IL-8 and IL-17 play a critical role in the pathogenesis of acne, while the role of IL-6 and IL-22 is less significant.
INDIAN JOURNAL OF DERMATOLOGY
(2023)
Letter
Dermatology
Savitha Bathula, Kabir Sardana, Ananta Khurana
