Article
Multidisciplinary Sciences
Xue Xu, Ali Naseri, Jos Houbraken, Farzaneh Akbari, Xiaodong Wang, Rongfen Zhao, Hong Zhang, Mohammad Javad Najafzadeh, Shuwen Deng
Summary: In Mashhad, Iran, A. flavus is the most common Aspergillus species causing onychomycosis. MALDI-TOF MS shows promise as a rapid and accurate identification tool, particularly for common Aspergillus species. Terbinafine, posaconazole, and echinocandins were the most effective antifungal drugs against the Aspergillus isolates studied, suggesting terbinafine as a preferred treatment option.
SCIENTIFIC REPORTS
(2021)
Letter
Immunology
Joerg Hofmann, Stephanie Kramer, Klaus R. Herrlinger, Kathrin Jeske, Martin Kuhns, Sabrina Weiss, Rainer G. Ulrich, Detlev H. Krueger
Summary: We report the molecular evidence of Tula virus infection in an immunocompetent patient from Germany, showing typical signs of hantavirus disease. Despite being considered nonpathogenic, accumulating evidence suggests that Tula virus infection poses a threat to human health.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Biology
Xia Wang, Jiaxuan Cheng, Jiawei Shen, Liguo Liu, Ningning Li, Ning Gao, Feng Jiang, Qi Jin
Summary: The extracellular contractile injection systems (eCISs) are present in the genomes of many bacteria and archaea, with Photorhabdus Virulence Cassette (PVC) being a typical member. PVC delivers effectors directly into mammalian macrophages by loading them into the inner tube and injecting them into the cells, disrupting dNTP pools and actin cytoskeleton formation to kill the target cells.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Article
Microbiology
Julia Villar Rodriguez, Ana Maria Perez Pico, Francisco Manuel Garcia Blazquez, Juan Francisco Moran Cortes, Raquel Mayordomo Acevedo
Summary: Through a study of 214 samples using an FLIR E60 BX camera, it was found that men are more prone to onychomycosis than women. There was a correlation between the presence of infection and nail temperature, with higher temperatures observed in yeast infections (+1 degrees C) and lower temperatures in dermatophyte infections (-2 degrees C). Older participants also exhibited higher temperatures by almost 1 degree C. Thermography can be considered a new diagnostic method for asymptomatic or incipient onychomycosis, provided that the thermographic camera is sufficiently sensitive and the appropriate procedure is followed, although fungal culture is always necessary to confirm recovery after treatment.
Review
Microbiology
Chiara Albano, Sara Bagarello, Salvatore Giordano, Maria Fiorella Sanfilippo, Calogero Comparato, Giuseppe Scardino, Valeria Garbo, Giovanni Boncori, Anna Condemi, Antonio Cascio, Claudia Colomba
Summary: Granulicatella spp. is a challenging Gram-positive cocci with fastidious nutritional requirements, commonly found in the human oral cavity, urogenital and intestinal tracts. Despite its difficulty in culture isolation, it can cause severe infectious diseases, notably infective endocarditis.
Article
Biochemistry & Molecular Biology
Rumen Harizanov, Nina Tsvetkova, Aleksandra Ivanova, Raina Enikova, Mihaela Videnova, Iskra Rainova, Eleonora Kaneva, Iskren Kaftandjiev, Dimitar Strashimirov, Nina Yancheva-Petrova, Ivan Simeonovski, Viktoria Levterova, Nikolay Yanev
Summary: This study aimed to establish the prevalence of Pneumocystis jirovecii infection in human hosts with different immune status and compare it with classical staining methods. The results showed that real-time PCR had higher sensitivity than staining methods, and the choice of a method for sample collection and examination played an important role in the efficiency of the laboratory diagnostics.
Article
Health Care Sciences & Services
Bozhidar Vergov, Andreana Angelova, Alexandra Baldzhieva, Yordan Kalchev, Georgi Tsochev, Marianna Murdjeva
Summary: Improvements in medical care have transformed severe diseases into chronic conditions, but the treatment and use of medical devices often come with specific complications. This article presents a clinical case of a long-term dialysis patient who acquired a rare opportunistic infection called Gordonia sputi. In recent years, the incidence of Gordonia spp. infections has been increasing among immunocompromised patients with central venous catheters. Isolating and identifying Gordonia spp. is challenging and requires modern techniques. Treatment usually involves persistent therapy and may result in the extraction of the central venous catheter, posing additional risks and costs to the patient. Additionally, this study examines the effects of long-term renal replacement therapy and chronic hepatitis C virus infection on the patient's immune status. Successfully eradicating the infection was achieved through antibiotic therapy and immunostimulation with Inosine pranobex, eliminating the need for central venous catheter replacement.
Letter
Immunology
Jan Brabec, Manuel Uribe, Jenny J. Chaparro-Gutierrez, Carlos Hermosilla
Summary: We have identified an adult Spirometra mansoni tapeworm retrieved from a crab-eating fox in Colombia, confirming the presence of this parasite in South America. This tapeworm is responsible for human sparganosis, which is commonly reported in Southeast Asia, and is the second species in the Americas with known zoonotic potential.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Dermatology
Yesim Akpinar Kara
Summary: This study aimed to determine the prevalence of fungal agents in nail dystrophies and emphasized the importance of laboratory confirmation tests in diagnosis. Among the patients, 68% were found to have fungal pathogens causing nail disorders, with Aspergillus species being the most common pathogen.
JOURNAL OF COSMETIC DERMATOLOGY
(2021)
Article
Microbiology
Justin Gutierrez, Amanda Bakke, Maritza Vatta, A. Rod Merrill
Summary: This study discovered several plant extracts and flavonoids that effectively inhibit the growth of Streptomyces scabies. Myrrh extract from Commiphora myrrha showed the strongest antibacterial activity against this pathogen.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Dermatology
Laetitia Laroche, Nathalie Bourgeois, Laurence Lachaud, Philippe Rispail
Summary: This study retrospectively analyzed ungual hyphomycosis cases diagnosed at Montpellier Hospital from 1991 to 2019. It found that approximately 17.25% of patients had nail colonisation by pseudo-dermatophytes or moulds. Clinical reports of patients with nail aspergillosis identified cardiovascular, endocrine, cancer, and skin diseases as potential contributing factors to the condition.
Article
Veterinary Sciences
Wenqi Liang, Xiangdong Wu, Zhen Ding, Shengwei Zhong, Xinjie Qian, Pei Ye, Hao Liu, Zheng Chen, Jinhua Zhang, Huabin Cao, Guoliang Hu, Junrong Luo, Zuohua Li, Nengshui Ding, Ruiming Hu
Summary: This study reported an outbreak of PTV in a large-scale pig farm in China, with severe symptoms and high mortality rate. A novel PTV strain, named HeNZ1, was isolated and found to be genetically and antigenically different from other Chinese PTV-2 strains. The results indicate that HeNZ1 is a highly virulent PTV-2 strain with significant genetic diversity and antigenic drift potential.
BMC VETERINARY RESEARCH
(2023)
Article
Emergency Medicine
John Rains, Jacob Kesterson
Summary: Bradycardia can vary in severity and prompt recognition of potential causes is crucial for proper treatment and disposition. This paper presents a case of symptomatic bradycardia in an 89-year-old female caused by ophthalmic timolol, highlighting the importance of careful medication selection.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Nicola M. Fischer, Andrea Altewischer, Surendra Ranpal, Serena Dool, Gerald Kerth, Sebastien J. Puechmaille
Summary: Emerging infectious diseases pose a major threat to human, animal, and plant health. A study found that hibernacula walls are the main environmental reservoir of the White-Nose disease fungus, with each hibernaculum having a unique fungal population.
Review
Infectious Diseases
Nallely Nava-Perez, Lisset G. Neri-Garcia, Oscar E. Romero-Gonzalez, Joshua A. Terrones-Cruz, Laura C. Garcia-Carnero, Hector M. Mora-Montes
Summary: Sporotrichosis is a significant subcutaneous mycosis that poses a high risk to human and animal health globally. Sporothrix globosa, an underestimated species, shows the lowest virulence among the pathogenic Sporothrix clade members but is important due to its worldwide distribution. This review provides comprehensive information about S. globosa, including its genome and proteomic information, and compares it with S. schenckii and S. brasiliensis to explain the observed differences in terms of virulence, host immune response, and antifungal sensitivity.
INFECTION AND DRUG RESISTANCE
(2022)
