Article
Chemistry, Analytical
Jianlong Ma, Xiaofeng Lu, Yong Guo, Zhijun Wang
Summary: This study synthesized a near-infrared (NIR) Cys-special probe (MCyA) that could precisely and quickly detect Cys activity. The observations showed that the endogenous Cys activity was depressed under oxidative stress, but dramatically increased with omeprazole stimulation in HepG2 cells. MCyA was also successfully used to image the upregulation of Cys level in HepG2 cells in the presence of methionine (Met). Overall, MCyA is a novel and practical tool to study Cys-related physiological and pathological processes.
Article
Spectroscopy
Chang Liu, Huimin Yan, Jianhong Wu, Zhiming Wang, Song He, Liancheng Zhao, Xianshun Zeng
Summary: A new near-infrared fluorescent probe Qcy-OH based on an acceptor-donor-acceptor (ADA) pi-electron system with a turn-on mechanism was developed for monitoring pH fluctuations in biological systems. The probe showed a strong pH-sensitive response and high selectivity for intracellular lysosomes, enabling the tracking of lysosomal pH changes.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Review
Chemistry, Inorganic & Nuclear
Tao Jia, Guanying Chen
Summary: Fluorescence imaging in the second near-infrared biological window offers unique advantages and lanthanide-based nanoparticles as NIR-II probes have attracted extensive attention. Recent advances have enabled lanthanide-based nanoparticles to exhibit well-defined luminescence profiles in the NIR-II region.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Chemistry, Applied
Meng-Jiao Gao, Yun Hua, Jia-Qi Xu, Li-Xia Zhang, Shuo Wang, Yan-Fei Kang
Summary: In this study, a large stokes shift and near-infrared probe DCM-HNU was designed and synthesized to visualize H2O2 in living cells and zebra fish, showing great potential for exploring the function and participation of H2O2 in biological systems.
Article
Biochemistry & Molecular Biology
Jiale Wang, Zhao Jiang, Cheng Huang, Shimao Zhao, Senqiang Zhu, Rui Liu, Hongjun Zhu
Summary: In this study, we designed and synthesized two near-infrared nanoprobes by tuning the electron-donating ability of the substituents on the core structure of boron-dipyrromethene (BODIPY) molecules. These self-assembled nanoparticles (NPs) exhibited near-infrared emission, large Stokes shifts, and high fluorescence quantum efficiency, which improved water dispersibility and reduced interference from biological background fluorescence. In vitro experiments showed that the NPs could enter tumor cells and illuminate the cytoplasm through fluorescence imaging. In vivo imaging with BDP-B NPs, which had unique near-infrared emission, demonstrated their ability to accumulate in tumors and effectively illuminate them via the enhanced penetrability and retention effect (EPR). Thus, BODIPY-based nanomicelles with near-infrared fluorescence emission provide a promising research foundation for the development of in vivo optical nanoprobes.
Article
Spectroscopy
Yang Wang, Xiao-Lei Xue, Qi Zhang, Kun-Peng Wang, Shaojin Chen, Linsheng Tang, Zhi-Qiang Hu
Summary: This study reports a novel near-infrared fluorescent probe CyOE, which exhibits high selectivity, sensitivity, and good water solubility for rapid detection of hydrazine in aqueous solutions and real water samples.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Polymer Science
Peiyun Cheng, Na Liang, Wei Zhao, Xianfeng Gong, Weijia Wang, Shaoping Sun
Summary: An amphiphilic polymer mPEG-CS-Bio-Hz-Q with NIR fluorescence imaging, active tumor targeting, minimized protein adsorption, and pH-responsive drug release capabilities was designed and synthesized for paclitaxel (PTX) delivery. The PTX-loaded mPEG-CS-Bio-Hz-Q micelles had an average size of 123.5 nm, and showed pH-triggered drug release behavior. Cellular uptake study demonstrated efficient internalization and bright fluorescence of the micelles in MCF-7 cells. In vivo investigation revealed high antitumor activity and excellent safety of the micelles. The mPEG-CS-Bio-Hz-Q micellar system holds promise for bioimaging and cancer therapy.
EUROPEAN POLYMER JOURNAL
(2023)
Review
Chemistry, Inorganic & Nuclear
Jing Wang, Zhijia Sheng, Jingru Guo, Hai-Yan Wang, Xiaolian Sun, Yi Liu
Summary: Optical imaging is widely used as an emerging in vivo imaging technology in basic research and clinical follow-up, providing real-time physiological and pathological information that cannot be obtained from in vitro testing. NIR optical imaging offers advantages such as spatiotemporal resolution and a relatively high signal-to-noise ratio compared to traditional imaging strategies. This review focuses on the structure design of molecular NIR fluorescent probes and their applications in bioimaging and diagnosis of typical nephron-urological diseases, as well as the potential development and current difficulties in this field.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Chemistry, Applied
Yi-Jun Gong, Dan-Dan Feng, Wei-Ning Liu, Jing-Kun Fang, Suling Feng
Summary: An optimized route was established for facile preparation of the hemi-benzothiazolecyanine dye MTR, and a self-immolative NIR probe MTR-HH was successfully designed and synthesized for detecting H2O2 with a remarkable 284-fold fluorescent enhancement. The probe showed great potential in visualizing endogenous H2O2 in living cells and mice.
Review
Biochemistry & Molecular Biology
Kyohei Okubo, Masakazu Umezawa, Kohei Soga
Summary: Near infrared (NIR) light has high transparency in biological tissue, and recent advances in NIR fluorophores have enabled effective use of the NIR optical window for in vivo bioimaging and photodynamic therapy. This review focuses on the development of hybrid nanostructures by utilizing the polarity and vibrational energy of ions and molecules surrounding the luminescence centers, with the aim of reducing heat emission and achieving bright luminescence. The guidelines proposed in the review are based on the multiphonon relaxation theory and emphasize the importance of surrounding luminescence centers with ions with low vibrational energy or molecules with small chemical polarity.
Article
Nanoscience & Nanotechnology
Fang Tang, Jin-Yu Liu, Cheng-Yan Wu, Ya-Xuan Liang, Zhong-Lin Lu, Ai-Xiang Ding, Ming-Di Xu
Summary: The study developed multifunctional nonviral gene vectors for gene delivery, bioimaging, and cancer treatment. By combining photodynamic therapy and gene therapy, collaborative cancer treatment with significantly enhanced cancer cell-killing effect was achieved.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Analytical
Xiaochun Wang, Cuiping Ma
Summary: In this study, a near-infrared fluorescent chemosensor EQR-TYR was developed for highly sensitive and selective detection of TYR activity. EQR-TYR showed good water-solubility, low detection limit, remarkably large Stokes shift and fast response, and was successfully applied in live cells and mouse models.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Multidisciplinary
Yupeng Liu, Josh Haipeng Lei, Gang Wang, Zhiming Zhang, Jun Wu, Bohan Zhang, Huiqi Zhang, Enshan Liu, Liming Wang, Tzu-Ming Liu, Guichuan Xing, Defang Ouyang, Chu-Xia Deng, Zikang Tang, Songnan Qu
Summary: This study successfully fabricated carbon dots (CDs) with dominant near-infrared (NIR) absorption/emission peaks in aqueous solution and enhanced their photoluminescence quantum yields (PLQY) through surface engineering. Compared to commercial NIR dyes, these modified CDs exhibit improved photostability and lower cost, and they also demonstrate advantages in in vivo bioimaging.
Article
Biochemical Research Methods
Zhuye Shang, Jianhua Liu, Qingtao Meng, Yue Wang, Cheng Zhang, Zhiqiang Zhang
Summary: In this study, a near-infrared fluorescent probe SZY was successfully synthesized and applied for the detection of HSO3- in food samples and live animals. The probe showed fast response time, high water solubility, low cytotoxicity, and could semi-quantitatively analyze HSO3- levels using a colorimetric method.
Review
Chemistry, Multidisciplinary
Hui Li, Xin Wang, Tymish Y. Ohulchanskyy, Guanying Chen
Summary: Light in the near-infrared (NIR) spectral region is increasingly used in bioapplications due to its deeper penetration in biological tissues. Lanthanide-doped luminescent nanoparticles with excitation and/or emission in the NIR range are gaining attention for noninvasive biological applications, offering unique optical properties such as large Stokes shift, sharp luminescence emissions, long lifetimes, and photostability. Advanced strategies for enhancing the luminescence brightness of these nanoparticles have been introduced, along with a review of their superior biophotonic applications in high-resolution imaging, single-nanoparticle-level detection, and tissue-penetrating diagnostics and therapeutics.
ADVANCED MATERIALS
(2021)
