Review
Immunology
Pilar Cornejo Ulloa, Bastiaan P. Krom, Monique H. van der Veen
Summary: Sex steroid hormones can affect both oral microbiota and host cells, potentially leading to oral health problems. Current research mainly focuses on the impact of hormonal changes on oral microorganisms, while broader studies have suggested new hypotheses about the effects of SSH.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Medical Laboratory Technology
Thomas G. Morris, Jonathan Layley, Robin Geevarghese, Lucille Steele, Joshua Ssali, Mehdi Mirzazadeh
Summary: This study established adult and neonatal TSH DBS reference intervals and determined the relationship between serum and DBS TSH.
ANNALS OF CLINICAL BIOCHEMISTRY
(2022)
Review
Endocrinology & Metabolism
Annalisa Geraci, Riccardo Calvani, Evelyn Ferri, Emanuele Marzetti, Beatrice Arosio, Matteo Cesari
Summary: During aging and menopausal transition, women experience progressive muscle degeneration, leading to an increased risk of sarcopenia. Estradiol plays a crucial role in skeletal muscle function by stimulating satellite cell proliferation and limiting inflammatory stress damage. Estradiol Replacement Therapy, combined with nutrition and physical activity programs, can be a valuable tool in treating sarcopenia in women.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Veterinary Sciences
Yatta Linhares Boakari, Erin Legacki, Maria Augusta Alonso, Ana Carolina Francisco dos Santos, Marcilio Nichi, Alan J. Conley, Claudia Barbosa Fernandes
Summary: This study evaluated differences in hormonal levels in mule and equine foals after birth, suggesting potential hormonal environment disparities between mules and horses, which are crucial for early diagnosis and intervention of hormonal imbalances in neonatal mules.
VETERINARY SCIENCES
(2022)
Review
Environmental Sciences
J. O. Ojoghoro, M. D. Scrimshaw, J. P. Sumpter
Summary: Steroid hormones are crucial natural hormones that regulate physiological processes in vertebrates; both natural and synthetic steroid hormones have been identified as widespread aquatic contaminants; experiments have shown that even at extremely low concentrations, steroid hormones can adversely affect reproduction in aquatic vertebrates.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Review
Nutrition & Dietetics
Christian Fricke, Ulrich Voderholzer
Summary: This article provides an overview of the endocrine changes associated with malnutrition and underweight, which serves as a basis for understanding the health risks associated with being underweight. The regulation of hunger and satiety is particularly important in the intentional influence on body weight. There is potential for improvement through the administration of hormones, but more studies are needed.
Article
Endocrinology & Metabolism
Liang-Jen Wang, Ying-Hua Huang, Wen-Jiun Chou, Sheng-Yu Lee
Summary: This study found that there were no changes in thyroid or growth hormones associated with different medication treatments for children with ADHD within one year. However, it is important to closely monitor patients' growth and the appropriateness of drug dosage.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Cell Biology
Nikolai Jaschke, Andrew Wang, Lorenz C. Hofbauer, Martina Rauner, Tilman D. Rachner
Summary: As life expectancy continues to increase, there is a growing scientific interest in finding medical interventions to alleviate age-related pathologies. Testosterone replacement therapy (TRT) is seen by some as a potential solution for aging men, although its safety remains uncertain. Data from the animal kingdom highlights the plasticity of individual testosterone trajectories across the lifespan.
AGEING RESEARCH REVIEWS
(2021)
Review
Endocrinology & Metabolism
Adam Morton, Stephanie Teasdale
Summary: Pregnancy leads to significant physiological changes in endocrine hormones, electrolytes, and gland morphology, affecting endocrine test results. Awareness of these changes and safety considerations for testing and imaging is crucial for managing endocrine disorders in pregnancy.
CLINICAL ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Marcela Valko-Rokytovska, Peter Ocenas, Aneta Salayova, Zuzana Kostecka
Summary: Metabolomics is a promising analytical method for the diagnosis and prognosis of breast cancer, offering a comprehensive non-invasive approach. Targeted metabolomics of steroid hormones play a crucial role in the classification and development of breast cancer, with high potential for effective diagnosis and monitoring of disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Flavia Tramontana, Sofia Battisti, Nicola Napoli, Rocky Strollo
Summary: Gender disparities in COVID-19 severity may be influenced by sex hormones like estrogen and androgen, which regulate pathogenic elements such as virus entry factors and immune responses. Understanding the role of sex hormones in COVID-19 could lead to targeted therapeutic interventions and personalized medicine based on gender.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Jose Cipolla-Neto, Fernanda Gaspar Amaral, Jose Maria Soares-Jr, Camila Congentino Gallo, Andre Furtado, Jose Eduardo Cavaco, Isabel Goncalves, Cecilia Reis Alves Santos, Telma Quintela
Summary: This study reviews the various effects of melatonin on biological functions, discusses the interactions between melatonin and sex hormones, and highlights the impact of melatonin on female gonadal steroidogenesis and hormonal control. It suggests that there is ambiguity in the influence of sex differences on the circadian rhythms of melatonin, and the debate surrounding the reciprocal relationship between melatonin and reproductive hormones remains inconclusive.
NEUROENDOCRINOLOGY
(2022)
Review
Medicine, General & Internal
M. Gurnell, L. G. Heaney, D. Price, A. Menzies-Gow
Summary: Secondary adrenal insufficiency often results from excessive exogenous corticosteroid therapy, particularly oral corticosteroids. Biologic therapies offer a potential solution for reducing or eliminating maintenance OCS in severe asthma, but there is a need for further clinical trials to define strategies for early identification and treatment of AI, as well as safe OCS withdrawal in routine practice.
JOURNAL OF INTERNAL MEDICINE
(2021)
Review
Cell Biology
Wenjiao Liu, Ting Gong, Fangxiong Shi, Houqiang Xu, Xiang Chen
Summary: This article explores the signaling mechanisms through which taste receptor factors influence testosterone synthesis in male reproduction and discusses their potential role in regulating male fertility.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Psychology, Biological
Peter A. Bos, Franca H. Parianen Lesemann, Hannah Spencer, Dan J. Stein, Jack van Honk, Estrella R. Montoya
Summary: Emotional reactivity to others' distress is essential for a caring response, but rising testosterone levels may also facilitate protection, especially in response to infant distress. Interestingly, testosterone can increase emotional responses towards empathy-eliciting images of children, with the strongest effect seen in participants with strong protective tendencies.
BIOLOGICAL PSYCHOLOGY
(2021)
Editorial Material
Medicine, General & Internal
P. J. Frost, M. P. Wise
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2018)
Article
Critical Care Medicine
Jennifer Holmes, Gethin Roberts, John Geen, Alan Dodd, Nicholas M. Selby, Andrew Lewington, Gareth Scholey, John D. Williams, Aled O. Phillips
JOURNAL OF CRITICAL CARE
(2018)
Article
Critical Care Medicine
Yahya Shehabi, Ary Serpa Neto, Belinda D. Howe, Rinaldo Bellomo, Yaseen M. Arabi, Michael Bailey, Frances E. Bass, Suhaini Bin Kadiman, Colin J. McArthur, Michael C. Reade, Ian M. Seppelt, Jukka Takala, Matt P. Wise, Steve A. Webb
Summary: The study aimed to quantify potential heterogeneity of treatment effect (HTE) of early sedation with dexmedetomidine (DEX) compared with usual care. Results showed that DEX was associated with lower 90-day mortality in patients over 65 years old, while younger patients may experience increased mortality with DEX. Further research is needed to confirm these findings.
INTENSIVE CARE MEDICINE
(2021)
Article
Critical Care Medicine
Yahya Shehabi, Ary Serpa Neto, Rinaldo Bellomo, Belinda D. Howe, Yaseen M. Arabi, Michael Bailey, Frances E. Bass, Suhaini Bin Kadiman, Colin J. McArthur, Michael C. Reade, Ian M. Seppelt, Jukka Takala, Matt P. Wise, Steve A. Webb
Summary: The study aimed to evaluate the association between different infusion rates of dexmedetomidine and propofol in combination and mortality, taking age into account. The results showed that increasing the dose of propofol was associated with decreased mortality in patients aged 65 years or below, while increasing the dose of dexmedetomidine may be associated with increased mortality.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Critical Care Medicine
Francesca M. Stefanizzi, Lu Zhang, Antonio Salgado-Somoza, Josef Dankiewicz, Pascal Stammet, Christian Hassager, Matthew P. Wise, Hans Friberg, Tobias Cronberg, Alexander Hundt, Jesper Kjaergaard, Niklas Nielsen, Yvan Devaux
Summary: This study identified circulating circRNAs associated with clinical outcome after cardiac arrest, with circNFAT5 potentially aiding in predicting neurological outcome and survival in combination with established biomarkers of cardiac arrest.
INTENSIVE CARE MEDICINE EXPERIMENTAL
(2022)
Article
Anesthesiology
Mark Borthwick, Anders Granholm, Soren Marker, Mette Krag, Theis Lange, Matt P. Wise, Stepani Bendel, Frederik Keus, Anne Berit Guttormsen, Joerg C. Schefold, Jorn Wetterslev, Anders Perner, Morten Hylander Moller
Summary: Critically ill patients are at risk of gastrointestinal bleeding, and pharmacological stress ulcer prophylaxis (SUP) is commonly used to minimize this risk. The effect of enteral nutrition as SUP on GI bleeding rates is uncertain, with conflicting data and variable practice. This study aims to explore the association between enteral nutrition and GI bleeding rates in ICU patients and evaluate any interactions with pharmacologic SUP. The results may provide important insights for guiding practice and designing future clinical trials on the effect of enteral nutrition on GI bleeding.
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2023)
Article
Critical Care Medicine
Alice Lagebrant, Margareta Lang, Niklas Nielsen, Kaj Blennow, Josef Dankiewicz, Hans Friberg, Christian Hassager, Janneke Horn, Jesper Kjaergaard, Mikael A. Kuiper, Niklas Mattsson-Carlgren, Tommaso Pellis, Christian Rylander, Roger Sigmund, Pascal Stammet, Johan Unden, Henrik Zetterberg, Matt P. Wise, Tobias Cronberg, Marion Moseby-Knappe
Summary: This study aimed to investigate whether levels of brain injury markers in blood could predict the likelihood of hypoxic ischaemic encephalopathy (HIE) on head computed tomography (CT) after cardiac arrest. The results showed that these biomarker levels can assess the likelihood of a patient presenting with HIE on CT and could be used to select suitable patients for CT examination in unconscious cardiac arrest patients.
Correction
Critical Care Medicine
Francesca M. Stefanizzi, Lu Zhang, Antonio Salgado-Somoza, Josef Dankiewicz, Pascal Stammet, Christian Hassager, Matthew P. Wise, Hans Friberg, Tobias Cronberg, Alexander Hundt, Jesper Kjaergaard, Niklas Nielsen, Yvan Devaux
INTENSIVE CARE MEDICINE EXPERIMENTAL
(2022)
Article
Clinical Neurology
Nicholas J. Ashton, Marion Moseby-Knappe, Andrea L. Benedet, Lana Grotschel, Juan Lantero-Rodriguez, Thomas K. Karikari, Christian Hassager, Matt P. Wise, Pascal Stammet, Jesper Kjaergaard, Hans Friberg, Niklas Nielsen, Tobias Cronberg, Henrik Zetterberg, Kaj Blennow
Summary: This study found that blood levels of p-tau and A13 peptides after cardiac arrest differ in dynamics and association with neurological outcome compared to neural injury markers NfL and t-tau. Serum p-tau levels were significantly elevated at 24, 48, and 72 hours, with the strongest association observed at 24 hours. In contrast, A1342 and A1340 concentrations showed weak association with neurological outcome.
Article
Critical Care Medicine
Joseph R. R. Riddell, Benjamin J. J. Jones, Bruno M. M. Fernandes, Daniel J. J. Law, Jackie A. A. Cooper, Matt P. P. Wise
Summary: Post hoc analysis of the FACTT trial showed associations between mechanical ventilation indices and pulmonary artery pressure in ARDS patients, suggesting possible clinical targets for right ventricular protective mechanical ventilation strategies.
Article
Critical Care Medicine
Rupert F. G. Simpson, Josef Dankiewicz, Grigoris Karamasis, Paolo Pelosi, Matthias Haenggi, Paul J. Young, Janus Christian Jakobsen, Jonathan Bannard-Smith, Pedro D. Wendel-Garcia, Fabio Silvio Taccone, Per Nordberg, Matt P. Wise, Anders M. Grejs, Gisela Lilja, Roy Bjorkholt Olsen, Alain Cariou, Jean Baptiste Lascarrou, Manoj Saxena, Jan Hovdenes, Matthew Thomas, Hans Friberg, John R. Davies, Niklas Nielsen, Thomas R. Keeble
Summary: This study found that the effects of targeted hypothermia at 33 degrees C compared to normothermia did not vary significantly based on the average time to achieve hypothermia in post cardiac arrest patients. The study also showed that the fastest achieving hypothermia did not have significantly better outcomes than those in the normothermia group.
Article
Critical Care Medicine
Katarina Heimburg, Tobias Cronberg, Asa B. Tornberg, Susann Ullen, Hans Friberg, Niklas Nielsen, Christian Hassager, Janneke Horn, Jesper Kjaergaard, Michael Kuiper, Christian Rylander, Matt P. Wise, Gisela Lilja
Summary: Survivors of out-of-hospital cardiac arrest (OHCA) experience more limitations in physical function compared to a control group of ST elevation myocardial infarction (STEMI) patients.
RESUSCITATION PLUS
(2022)
Article
Critical Care Medicine
Joachim During, Martin Annborn, Alain Cariou, Michelle S. Chew, Josef Dankiewicz, Hans Friberg, Matthias Haenggi, Zana Haxhija, Janus C. Jakobsen, Halvor Langeland, Fabio Silvio Taccone, Matthew Thomas, Susann Ullen, Matt P. Wise, Niklas Nielsen
Summary: This study found that targeted temperature management at 33 degrees C (TTM33) was not associated with higher mortality in unconscious survivors of out-of-hospital cardiac arrest (OHCA) who received vasopressor support on admission.
Article
Critical Care Medicine
Katarina Heimburg, Gisela Lilja, Asa B. Tornberg, Susann Ullen, Erik Blennow Nordstrom, Hans Friberg, Niklas Nielsen, Lisa Gregersen Ostergaard, Anders M. Grejs, Helen Hill, Thomas R. Keeble, Hans Kirkegaard, Marco Mion, Christian Rylander, Magnus Segerstrom, Johan Unden, Matthew P. Wise, Tobias Cronberg
Summary: The aim of this study is to investigate physical activity levels among out-of-hospital cardiac arrest (OHCA) survivors compared to a non-cardiac arrest (CA) control group with acute myocardial infarction (MI), exploring potential predictors of physical inactivity, and studying the relationship between self-reported and objectively measured physical activity. The results will provide novel information about physical activity among OHCA survivors.
RESUSCITATION PLUS
(2021)
Article
Critical Care Medicine
Luca Cioccari, Nora Luethi, Michael Bailey, Yahya Shehabi, Belinda Howe, Anna S. Messmer, Helena K. Proimos, Leah Peck, Helen Young, Glenn M. Eastwood, Tobias M. Merz, Jukka Takala, Stephan M. Jakob, Rinaldo Bellomo