Article
Cardiac & Cardiovascular Systems
Julia Karady, Thomas Mayrhofer, Maros Ferencik, John T. Nagurney, James E. Udelson, Andreas A. Kammerlander, Jerome L. Fleg, W. Frank Peacock, James L. Januzzi, Wolfgang Koenig, Udo Hoffmann
Summary: The study aimed to quantify differences between high-sensitivity cardiac troponin (hs-cTn) assays and determine whether these differences may result in different management recommendations for patients with suspected acute coronary syndrome (ACS).
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Medical Laboratory Technology
Li Liu, Xueya Cai, Tanzy Love, Matthew Corsetti, Andrew M. M. Mathias, Andrew Worster, Jinhui Ma, Peter A. A. Kavsak
Summary: This study evaluated the effects of confounding factors on hs-cTnT concentrations and AMI diagnosis, and assessed the diagnostic performance of an optimized, integrated prediction model. The results showed that delta hs-cTnT played a more predominant role in AMI prediction than its confounders.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Manan Pareek, Kristian H. Kragholm, Anna Meta Dyrvig Kristensen, Muthiah Vaduganathan, Jannik L. Pallisgaard, Christina Byrne, Tor Biering-Sorensen, Christina Ji-Young Lee, Anders Nissen Bonde, Martin Bodtker Mortensen, Michael Maeng, Emil L. Fosbol, Lars Kober, Niels Thue Olsen, Gunnar H. Gislason, Deepak L. Bhatt, Christian Torp-Pedersen
Summary: The study found that individuals suspected of acute coronary syndrome who had consecutively elevated high-sensitivity troponin concentrations had the highest risk of death, while those with consecutively normal hsTnT concentrations had very low mortality rates, regardless of changes between measurements.
EUROPEAN HEART JOURNAL
(2023)
Article
Medical Laboratory Technology
Zhongxin Li, Shuo Yang, Jiao Qiao, Yuan Tan, Qi Liu, Boxin Yang, Weimin Feng, Liyan Cui
Summary: This study evaluated the analytical characteristics of a novel high-sensitivity cardiac troponin T test and validated its diagnostic performance for non-ST-segment elevation myocardial infarction. The results showed that the test is reliable and suitable for practical use in diagnosis.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Multidisciplinary Sciences
Joanne Eng-Frost, Simon Rocheleau, Kristina Lambrakis, Ehsan Khan, Anke van den Merkhof, Cynthia Papendick, Sam Lehman, Brian Chiang, Naomi Wattchow, Simon Steele, Scott Lorensini, Michael McCann, Kate George, Julian Vaile, Carmine De Pasquale, John French, Derek Chew
Summary: This study explored the association between early ICA and elevated hs-cTnT concentrations, and investigated the potential hs-cTnT threshold associated with benefit from an initial ICA strategy. The results showed that both dynamic and non-dynamic hs-cTnT elevations were associated with an increased risk of adverse events, and the hs-cTnT threshold for benefit from ICA strategy was lower in non-dynamic elevations.
Article
Medical Laboratory Technology
Moritz Biener, Evangelos Giannitsis, Thomas Thum, Christian Bar, Kiril M. Stoyanov, Christian Salbach, David De Gonzalo-Calvo, Norbert Frey, Matthias Mueller-Hennessen
Summary: The study found that miR-21-5p and miR-122-5p can predict the survival rate of patients with cardiovascular diseases in the emergency department, but do not add prognostic information to hs-cTnT.
CLINICAL BIOCHEMISTRY
(2022)
Review
Cardiac & Cardiovascular Systems
Connor M. O'Rielly, Tyrone G. Harrison, James E. Andruchow, Paul E. Ronksley, Tolu Sajobi, Helen Lee Robertson, Diane Lorenzetti, Andrew D. McRae
Summary: Chest pain is a common reason for emergency department visits, and clinical risk scores can help guide decisions on testing after ruling out myocardial infarction. This systematic review found that the HEART score with a cutoff value of 3 or less accurately identified the largest number of emergency department patients at low risk of major adverse cardiac events within 30 days, after ruling out myocardial infarction using high-sensitivity troponin testing.
CANADIAN JOURNAL OF CARDIOLOGY
(2023)
Review
Biology
Aleksey Michailovich Chaulin
Summary: Cardiac troponins T and I are important indicators for diagnosing myocardial cell damage and acute coronary syndrome. However, the role of gender in the serum levels of cardiac troponins T and I and the mechanisms for gender differences are still unknown.
Article
Medicine, General & Internal
Brunilda Alushi, Fabian Jost-Brinkmann, Adnan Kastrati, Salvatore Cassese, Massimiliano Fusaro, Karl Stangl, Ulf Landmesser, Holger Thiele, Alexander Lauten
Summary: The study found that in patients with chronic kidney disease, using higher assay-specific cutoff levels combined with early absolute changes can improve the diagnostic accuracy of hs-cTnT for non-ST-elevation acute coronary syndrome (NSTE-ACS).
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Murat Arslan, Jeroen Schaap, Pleunie P. M. Rood, Koen Nieman, Ricardo P. J. Budde, Bas M. van Dalen, Mohamed Attrach, Eric A. Dubois, Admir Dedic
Summary: Implementing the limit of detection of high-sensitivity troponin T as a gatekeeper may reduce the need for coronary computed tomography angiography in suspected acute coronary syndrome patients in the emergency department, improving medical efficiency.
Review
Medical Laboratory Technology
Paul Collinson
Summary: The high sensitivity method for cardiac troponin measurement has become the standard in laboratories, allowing for detection of low levels of troponin and rapid identification of patients with myocardial injury. Patients without acute coronary syndromes are more likely to be diagnosed with myocardial injury using this method, which may have implications for their prognosis and management.
CLINICAL BIOCHEMISTRY
(2021)
Article
Medical Laboratory Technology
Li Liu, William Consagra, Xueya Cai, Andrew Mathias, Andrew Worster, Jinhui Ma, Philip Rock, Tai Kwong, Peter A. Kavsak
Summary: This study evaluated the use of sex-specific delta thresholds for hs-cTnT assay in diagnosing AMI, finding that these thresholds had high diagnostic accuracy and were robust across different study populations.
CLINICAL CHEMISTRY
(2022)
Article
Cell Biology
Sara H. A. Agwa, Sherif Samir Elzahwy, Mahmoud Shawky El Meteini, Hesham Elghazaly, Maha Saad, Aya M. Abd Elsamee, Rania Shamekh, Marwa Matboli
Summary: The study assessed the predictive power of potential RNA panel expression in acute coronary syndrome, showing that the ABHD4-regulating RNA panel could be potential biomarkers for predicting ACS and stratifying the severity of the condition early. There was a significant association between the two miRNAs and ABHD4 mRNA, as well as the regulating FENDRR lncRNA.
Article
Cardiac & Cardiovascular Systems
Asthildur Arnadottir, Sune Pedersen, Rasmus Bo Hasselbalch, Jens P. Goetze, Lennart J. Friis-Hansen, Anna-Marie Bloch-Munster, Jan Skov Jensen, Henning Bundgaard, Kasper Iversen
Summary: This study is the first to report the early-release kinetics of cTn concentrations after different durations of experimental coronary balloon occlusion in humans. All assays detected a cTn increase after only 30 s of ischemia. hs-cTnI (Siemens) rose faster and reached a higher peak. Copeptin levels did not change significantly.
Article
Cardiac & Cardiovascular Systems
Elham Kayvanpour, Weng-Tein Gi, Farbod Sedaghat-Hamedani, David H. Lehmann, Karen S. Frese, Jan Haas, Rewati Tappu, Omid Shirvani Samani, Rouven Nietsch, Mustafa Kahraman, Tobias Fehlmann, Matthias Muller-Hennessen, Tanja Weis, Evangelos Giannitsis, Torsten Niederdrank, Andreas Keller, Hugo A. Katus, Benjamin Meder
Summary: The study investigated genome-wide miRNA levels in patients with suspected acute coronary syndromes, using a neural network to construct a miRNA classifier with excellent diagnostic value. The classifier showed high accuracy, sensitivity, specificity, and AUC, demonstrating the potential of neural network-based biomarkers for ACS diagnosis and the possibility of multi-modal data integration for improved precision and classification.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2021)