Review
Biochemistry & Molecular Biology
Ourania S. Kotsiou, Dimitrios Papagiannis, Rodanthi Papadopoulou, Konstantinos I. Gourgoulianis
Summary: This review provides insights into the potential role of Calprotectin in the pathophysiology of lung diseases, highlighting its multifunctionality in cellular processes and emphasizing its potential as a biomarker.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Ecology
Bruce A. Menge
Summary: This study evaluated the empirical support for environmental stress models (ESMs) and found that consumer pressure on prey typically decreases with increasing environmental stress (consumer stress model; CSM), while prey pressure on consumers (prey stress model; PSM) occurs less frequently. This contrasts with a prior survey, suggesting that consumers are generally more suppressed by stress than prey. Therefore, increased climate change-induced environmental stress is likely to reduce the impacts of consumers on prey more often than the reverse.
Review
Medical Laboratory Technology
Jennifer Murray, Klaartje B. Kok, Ruth M. Ayling
Summary: Inflammatory bowel disease (IBD) is a group of chronic conditions characterized by inflammation of the gastrointestinal tract. Endoscopy is the gold standard for diagnosis of IBD, but it is invasive and costly. Fecal calprotectin has been proven to be an accurate surrogate marker for intestinal inflammation in IBD.
CLINICAL CHEMISTRY
(2023)
Article
Statistics & Probability
Mingao Yuan, Ruiqi Liu, Yang Feng, Zuofeng Shang
Summary: This paper tackles the important problem of whether communities exist in observed hypergraphs. The authors systematically study the distinguishability between hypergraphs with community structure and their Erdos-Renyi counterparts. They propose concrete test statistics for distinguishing the models and make three main contributions: discovering a phase transition, deriving signal-to-noise ratio thresholds, and suggesting a computationally feasible test based on sub-hypergraph counts.
ANNALS OF STATISTICS
(2022)
Article
Medical Laboratory Technology
Lisa M. Johnson, Michael Spannagl, Nathalie Wojtalewicz, Juergen Durner
Summary: The study found that there is high variability in quantitative results between different manufacturers in fecal calprotectin assays, but qualitative interpretation in fecal pancreatic elastase assays seems to be harmonized across different manufacturers.
CLINICAL BIOCHEMISTRY
(2022)
Article
Computer Science, Information Systems
Pavlos Nikolopoulos, Sundara Rajan Srinivasavaradhan, Tao Guo, Christina Fragouli, Suhas N. N. Diggavi
Summary: Group testing is an effective technique to reduce the number of tests needed for identifying infected individuals by pooling diagnostic samples. This paper emphasizes the significance of considering community structure in testing contagious diseases to achieve optimal identification accuracy and lower the number of tests required. The authors propose community-aware group testing algorithms and demonstrate their superiority over traditional, community-agnostic group testing through simulations.
IEEE TRANSACTIONS ON INFORMATION THEORY
(2023)
Article
Primary Health Care
Karoline Freeman, Ronan Ryan, Nicholas Parsons, Sian Taylor-Phillips, Brian H. Willis, Aileen Clarke
Summary: The study found that the uptake of FC testing in clinical practice has been slow and inconsistent, indicating potential non-compliance with national recommendations.
BRITISH JOURNAL OF GENERAL PRACTICE
(2021)
Article
Public, Environmental & Occupational Health
Sarah Fishleder, Jeffrey R. Harris, Miruna Petrescu-Prahova, Marlana Kohn, Christian D. Helfrich
Summary: This article introduces the Clinical-Community Linkage Self-Assessment Survey (CCL Self-Assessment), a tool that can help community organizations identify the strengths and weaknesses of their linkages. Through literature review, expert feedback, and feasibility testing, the authors validate the effectiveness and feasibility of the CCL Self-Assessment survey.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Medicine, General & Internal
Eliza Lezyk-Ciemniak, Magdalena Tworkiewicz, Dominika Wilczynska, Anna Szaflarska-Poplawska, Aneta Krogulska
Summary: The article summarizes the use of fecal calprotectin (FC) in the diagnosis and monitoring of pediatric inflammatory bowel disease (IBD), emphasizing FC's role primarily in monitoring disease activity, predicting relapse, monitoring therapy efficacy, and postoperative relapses.
MEDICAL PRINCIPLES AND PRACTICE
(2021)
Article
Medicine, General & Internal
Shin Young Park, Sang Pyung Lee, Woo Jin Kim
Summary: This study found that increased gut inflammation, measured by fecal calprotectin, is associated with consciousness and systemic response in stroke patients, highlighting the potential usefulness of fecal calprotectin in stroke management.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Rheumatology
Valeria Carnazzo, Serena Redi, Valerio Basile, Patrizia Natali, Francesca Gulli, Francesco Equitani, Mariapaola Marino, Umberto Basile
Summary: Calprotectin (CLP) is a calcium-binding protein produced by neutrophils and monocytes in inflammation. Recent studies have focused on circulating CLP, which can be measured in different biological fluids using various methods. This review highlights the correlation between high levels of circulating CLP and specific autoantibodies in major autoimmune diseases, suggesting CLP measurement as a potential biomarker for monitoring disease outcome.
Article
Oncology
Yevgeniya J. Ioffe, Linda Hong, Maud Joachim-Celestin, Carmen Soret, Susanne Montgomery, Juli J. Unternaehrer
Summary: This study aimed to explore attitudes toward genetic germline testing and intentions to test in Latinas from Southern California. The findings revealed that patients' acculturation and education levels, as well as comfort with health care providers, are positively associated with attitudes and intentions toward genetic testing.
GYNECOLOGIC ONCOLOGY
(2023)
Review
Medicine, General & Internal
Marta Fortuny, Maria-Rosa Sarrias, Maria Torner, Ignacio Iborra, Ariadna Clos, Alba Ardevol, Ramon Bartoli, Rosa M. Morillas, Eugeni Domenech, Helena Masnou
Summary: The article summarizes the current evidence regarding the diagnostic and prognostic utility of calprotectin in ACLD.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Immunology
Mariangela Manfredi, Lieve Van Hoovels, Maurizio Benucci, Riccardo De Luca, Carmela Coccia, Pamela Bernardini, Edda Russo, Amedeo Amedei, Serena Guiducci, Valentina Grossi, Xavier Bossuyt, Carlo Perricone, Maria Infantino
Summary: This review highlights the widespread interest in circulating calprotectin (cCLP) as a biomarker of neutrophil-related inflammation in autoimmune rheumatic disease (ARD) and non-ARD. High cCLP levels are associated with worse structural outcomes in rheumatoid arthritis and to a lesser extent, in spondyloarthritis. In addition, cCLP can predict disease relapse in certain autoimmune diseases and severe manifestations of connective tissue diseases.
AUTOIMMUNITY REVIEWS
(2023)
Article
Gastroenterology & Hepatology
Almina Jukic, Latifa Bakiri, Erwin F. Wagner, Herbert Tilg, Timon E. Adolph
Summary: Faecal calprotectin, identified in the 1980s, has emerged as a validated biomarker for evaluating gut inflammation. Recent studies have highlighted the biological functions of calprotectin subunits S100A8 and S100A9 in orchestrating inflammatory responses at mucosal surfaces, suggesting its potential as a rheostat of mucosal inflammation and guiding patient-tailored medical therapy in inflammatory bowel diseases.
