Review
Peripheral Vascular Disease
Katherine L. Tucker, Lisa Hinton, Marcus Green, Lucy C. Chappell, Richard J. Mcmanus
Summary: This study examines the feasibility and effectiveness of self-monitoring during pregnancy, particularly in cases of hypertension. The results indicate that self-monitoring blood pressure and self-testing for proteinuria are feasible, acceptable, safe, and cost-effective, but do not improve the detection and control of hypertension.
HYPERTENSION RESEARCH
(2023)
Article
Medicine, General & Internal
Benshuo Cai, Xiaoying Yuan, Xingmin Li, Jun Xu, Juan Du
Summary: This study revealed a significant association between urinary congophilia and early-onset pre-eclampsia in the Chinese population, showing potential for predictive value in determining pregnancy outcomes in this patient group. Patients with early-onset PE and positive urinary congophilia had higher rates of iatrogenic prematurity and shorter latency periods between onset and delivery compared to those without urinary congophilia.
FRONTIERS IN MEDICINE
(2021)
Article
Biology
Jieun Kang, Sangwon Hwang, Taesic Lee, Kwangjin Ahn, Dong Min Seo, Seong Jin Choi, Young Uh
Summary: The prediction of pre-eclampsia is important, but current biomarkers face challenges in clinical settings. This study found that incorporating serum creatinine levels and considering renal hyperfiltration significantly improved PE prediction. The developed model is practical and can be easily applied in primary care settings.
Article
Multidisciplinary Sciences
Linda Ahenkorah Fondjo, Enoch Ofori Awuah, Samuel Asamoah Sakyi, Ebenezer Senu, Eric Detoh
Summary: This study explored the association between eNOS gene variants and nitric oxide levels among preeclamptic women in the Ghanaian population. The results showed that preeclamptic women had significantly lower nitric oxide concentration compared to normotensive women, and there were significant differences in nitric oxide levels among different VNTR intron 4 variants. Specific genotypes (4c4c and 4a4c) were more common in preeclamptic women. Possessing certain genotypes (4a4b and 4b4b) significantly decreased the risk of preeclampsia.
SCIENTIFIC REPORTS
(2023)
Article
Peripheral Vascular Disease
Erin M. Cleary, Nicholas W. Racchi, K. Grace Patton, Meghana Kudrimoti, Maged M. Costantine, Kara M. Rood
Summary: Intrapartum initiation of extended-release nifedipine is effective in preventing severe hypertension among individuals with preeclampsia with severe features. The use of nifedipine resulted in a lower rate of acute hypertension therapy, cesarean delivery, and neonatal intensive care unit admission compared to placebo. The neonatal composite outcome was similar between groups.
Article
Transplantation
Luca Valsecchi, Alessandro Galdini, Daniela Gabellini, Giacomo Dell'Antonio, Silvia Galbiati, Andrea Fanecco, Ilaria Vigano', Maddalena Smid, Rosa Bernardi, Silvia Maestroni, Hans J. Baelde, Gianpaolo Zerbini
Summary: Pre-eclampsia leads to inhibition of vascular endothelial growth factor (VEGF), which may cause an increase in VEGF synthesis in the kidney, leading to renal dysfunction. This non-canonical VEGF inhibition mechanism is possibly involved in podocyturia and the development of pre-eclampsia.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Peripheral Vascular Disease
Abu Mohd Naser, Feng J. He, Mahbubur Rahman, Norm R. C. Campbell
Summary: The study evaluated the relationship between estimated 24-hour urinary sodium excretion from different formulas and blood pressure, finding discrepancies between formula-estimated sodium levels and actual measurements. The formulas resulted in overestimation of sodium at lower levels and underestimation at higher levels, impacting the relationship with blood pressure.
Article
Environmental Sciences
Weili Yang, Joseph M. Braun, Ann M. Vuong, Zana Percy, Yingying Xu, Changchun Xie, Ranjan Deka, Antonia M. Calafat, Maria Ospina, Erika Werner, Kimberly Yolton, Kim M. Cecil, Bruce P. Lanphear, Aimin Chen
Summary: This study found that maternal exposure to organophosphate esters (OPEs) may be associated with increased blood pressure during pregnancy and hypertensive disorders of pregnancy (HDP), particularly with the concentrations of diphenyl phosphate (DPHP) and bis(2-chloroethyl) phosphate (BCEP) showing stronger correlations with elevated blood pressure. Di-n-butyl phosphate (DNBP) concentrations were also associated with HDP, albeit with borderline significance.
ENVIRONMENTAL RESEARCH
(2022)
Article
Hematology
Viktoria Bitsadze, Sylvie Bouvier, Jamilya Khizroeva, Eva Cochery-Nouvellon, Eric Mercier, Antonia Perez-Martin, Alexander Makatsariya, Jean-Christophe Gris
Summary: This study found that ADAMTS13 activity, antibodies, and antigen levels in newly pregnant women with obstetric antiphospholipid syndrome (oAPS) are associated with the occurrence of pre-eclampsia (PEcl). These markers serve as significant risk factors for PEcl and its subgroups, exhibiting acceptable discrimination power in predicting clinical events. ADAMTS13 may help identify pregnant women with oAPS who do not require escalated treatment strategies to prevent PEcl.
THROMBOSIS RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Ilona Jaszczuk, Izabela Winkler, Dorota Koczkodaj, Maciej Skrzypczak, Agata Filip
Summary: This review article analyzes the role of C19MC miRNA in the development of pre-eclampsia and summarizes the current research data. The results indicate that C19MC miRNAs are significantly upregulated in placental tissue of pre-eclampsia patients and can be detected in high levels in the blood. Among them, miR-525-5p shows low expression in the plasma of the first trimester. By identifying these miRNAs, it may be possible to predict the development of pre-eclampsia before the onset of clinical symptoms, thereby avoiding serious complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Multidisciplinary Sciences
Marianna Danielli, Roisin C. Thomas, Clare L. Gillies, Jiamiao Hu, Kamlesh Khunti, Bee Kang Tan
Summary: This is the most comprehensive and up to date systematic review and meta-analysis on blood biomarkers for the early prediction of pre-eclampsia, highlighting the urgent need for further research to identify blood biomarkers that could predict the development of pre-eclampsia.
Article
Multidisciplinary Sciences
Endalamaw Tesfa, Abaineh Munshea, Endalkachew Nibret, Daniel Mekonnen, Mulusew Alemneh Sinishaw, Solomon Tebeje Gizaw
Summary: This study found significantly higher concentrations of serum uric acid and blood urea in pre-eclampsia patients compared to normotensive pregnant women, suggesting an association between serum uric acid, blood urea, and the condition. These biomarkers could potentially be used as diagnostic tools for pre-eclampsia, but further large-scale prospective studies are needed to verify these findings.
Article
Acoustics
K. G. Lau, M. Baloi, D. Dumitrascu-Biris, K. H. Nicolaides, N. A. Kametas
Summary: This study aimed to investigate the changes in ophthalmic artery Doppler indices and their association with blood pressure in pregnant women following acute antihypertensive treatment. The results showed that antihypertensive treatment led to a reduction in blood pressure and ophthalmic artery PSV ratio. There was a significant association between PSV ratio and MAP, SBP, and DBP in hypertensive pregnant women, which disappeared after blood pressure was reduced.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Pauline Boucheron, Gregory Lailler, Elodie Moutengou, Nolwenn Regnault, Amelie Gabet, Catherine Deneux-Tharaux, Sandrine Kretz, Clemence Grave, Claire Mounier-Vehier, Vassilis Tsatsaris, Genevieve Plu-Bureau, Jacques Blacher, Valerie Olie
Summary: This nationwide cohort study found that hypertensive disorders of pregnancy greatly increased the risk of chronic hypertension in primiparous women in the first years following childbirth. Women with HDP were more likely to develop chronic hypertension and sought medical help earlier.
EUROPEAN HEART JOURNAL
(2022)
Review
Peripheral Vascular Disease
Veronica Giorgione, Gwyneth Jansen, Jamie Kitt, Chahinda Ghossein-Doha, Paul Leeson, Basky Thilaganathan
Summary: There is an increased occurrence of cardiovascular diseases in women within 1 to 2 decades after a preeclamptic pregnancy. Recent evidence suggests that the abnormal biochemical and echocardiographic findings in preeclamptic women do not resolve after giving birth. Many women remain hypertensive in the immediate postnatal period, with some showing signs of cardiac dysfunction. Close monitoring and effective blood pressure control in the immediate postnatal period may lead to persistently lower blood pressures in women years after stopping medication. This review emphasizes the importance of delivering effective medical care in the fourth trimester of pregnancy to improve long-term cardiovascular health after a preeclamptic birth.
Article
Immunology
Mayu Yamamoto, Mikio Watanabe, Naoya Inoue, Ayano Watanabe, Haruka Ozaki, Mizuki Ohsaki, Yoh Hidaka, Yoshinori Iwatani
IMMUNOLOGICAL INVESTIGATIONS
(2020)
Article
Biochemistry & Molecular Biology
Hidemi Hashimoto, Mikio Watanabe, Naoya Inoue, Nachi Hirai, Emi Haga, Riku Kinoshita, Yoh Hidaka, Yoshinori Iwatani
Article
Immunology
Ayano Watanabe, Naoya Inoue, Mikio Watanabe, Mayu Yamamoto, Haruka Ozaki, Yoh Hidaka, Yoshinori Iwatani
IMMUNOLOGICAL INVESTIGATIONS
(2020)
Article
Cell Biology
Yuichi Mishima, Laura Brueckner, Saori Takahashi, Toru Kawakami, Junji Otani, Akira Shinohara, Kohei Takeshita, Ronald Garingalao Garvilles, Mikio Watanabe, Norio Sakai, Hideyuki Takeshima, Charlotte Nachtegael, Atsuya Nishiyama, Makoto Nakanishi, Kyohei Arita, Kinichi Nakashima, Hironobu Hojo, Isao Suetake
Article
Genetics & Heredity
Chika Honda, Mikio Watanabe, Rie Tomizawa, Norio Sakai
TWIN RESEARCH AND HUMAN GENETICS
(2019)
Article
Oncology
Masahiko Hayashida, Fumiyo Maekawa, Yoshinari Chagi, Futoshi Lioka, Yoichiro Kobashi, Mikio Watanabe, Hitoshi Ohno
LEUKEMIA & LYMPHOMA
(2020)
Article
Multidisciplinary Sciences
Karri Silventoinen, Aline Jelenkovic, Reijo Sund, Antti Latvala, Chika Honda, Fujio Inui, Rie Tomizawa, Mikio Watanabe, Norio Sakai, Esther Rebato, Andreas Busjahn, Jessica Tyler, John L. Hopper, Juan R. Ordonana, Juan F. Sanchez-Romera, Lucia Colodro-Conde, Lucas Calais-Ferreira, Vinicius C. Oliveira, Paulo H. Ferreira, Emanuela Medda, Lorenza Nistico, Virgilia Toccaceli, Catherine A. Derom, Robert F. Vlietinck, Ruth J. F. Loos, Sisira H. Siribaddana, Matthew Hotopf, Athula Sumathipala, Fruhling Rijsdijk, Glen E. Duncan, Dedra Buchwald, Per Tynelius, Finn Rasmussen, Qihua Tan, Dongfeng Zhang, Zengchang Pang, Patrik K. E. Magnusson, Nancy L. Pedersen, Anna K. Dahl Aslan, Amie E. Hwang, Thomas M. Mack, Robert F. Krueger, Matt McGue, Shandell Pahlen, Ingunn Brandt, Thomas S. Nilsen, Jennifer R. Harris, Nicholas G. Martin, Sarah E. Medland, Grant W. Montgomery, Gonneke Willemsen, Meike Bartels, Catharina E. M. van Beijsterveldt, Carol E. Franz, William S. Kremen, Michael J. Lyons, Judy L. Silberg, Hermine H. Maes, Christian Kandler, Tracy L. Nelson, Keith E. Whitfield, Robin P. Corley, Brooke M. Huibregtse, Margaret Gatz, David A. Butler, Adam D. Tarnoki, David L. Tarnoki, Hang A. Park, Jooyeon Lee, Soo Ji Lee, Joohon Sung, Yoshie Yokoyama, Thorkild I. A. Sorensen, Dorret Boomsma, Jaakko Kaprio
SCIENTIFIC REPORTS
(2020)
Article
Environmental Sciences
Daisuke Matsumoto, Fujio Inui, Chika Honda, Rie Tomizawa, Mikio Watanabe, Karri Silventoinen, Norio Sakai
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Article
Immunology
Mayumi Kawabata, Naoya Inoue, Mikio Watanabe, Ayaka Kobayashi, Yoh Hidaka, Akira Miyauchi, Yoshinori Iwatani
Summary: The study investigated the association between PD1 gene polymorphisms, PD-1 expression, thyroid PD-1/PD-L1 expression and the pathogenesis of autoimmune thyroid disease (AITD). The findings showed differences in functional PD1 rs36084323 polymorphism and thyroid PD-1/PD-L1 expression between GD and HD. Additionally, PD1 polymorphisms and PD1(+) Treg cells were found to be related to the severity of HD.
Article
Biochemistry & Molecular Biology
Isao Suetake, Shigeaki Nakazawa, Kazunobu Sato, Risa Mutoh, Yuichi Mishima, Toru Kawakami, Toshiki Takei, Mikio Watanabe, Norio Sakai, Toshimichi Fujiwara, Takeji Takui, Makoto Miyata, Akira Shinohara, Hironobu Hojo, Toshiaki Arata
Summary: The study investigated the structural dynamics of HP1 proteins in heterochromatin formation, showing differences in spatial separation and mobility between HP1 alpha and HP1 gamma. HP1 alpha may exhibit an auto-inactivated state, potentially influencing its physiological role in heterochromatin formation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Endocrinology & Metabolism
Hinako Homma, Mikio Watanabe, Naoya Inoue, Moeko Isono, Yoh Hidaka, Yoshinori Iwatani
Summary: The study revealed that polymorphisms in CYP26B1 and RARB genes were associated with susceptibility and prognosis of autoimmune thyroid disease (AITD), with CYP26B1 gene variations being related to the proportion of Th17 cells and levels of IL-17, and RARB gene variations being related to Th17 cell proportions, concentrations of IFN-gamma and IL-17, and susceptibility to AITD.
Article
Biochemistry & Molecular Biology
Tomomasa Kimura, Manabu Sakai, Nao Gojo, Mikio Watanabe, Narikazu Uzawa, Takayoshi Sakai
Summary: The HIF-1α signaling pathway plays a critical role in salivary gland development by promoting cell proliferation and cell cycle, not through autophagy and apoptosis. The ERK1/2 pathway acts upstream of HIF-1α in regulating its activity.
Article
Medicine, General & Internal
Natsuko Matsumoto, Jonguk Park, Rie Tomizawa, Hitoshi Kawashima, Koji Hosomi, Kenji Mizuguchi, Chika Honda, Ritsuko Ozaki, Yoshinori Iwatani, Mikio Watanabe, Jun Kunisawa
Summary: This study focused on the effects of nutrient intake on the gut microbiome in Japanese identical twins to exclude genetic differences. Twelve genera were identified to be sensitive to environmental factors, while Lactobacillus was relatively unaffected. Results showed associations between specific nutrient intake and abundance of certain genera in the gut microbiota.
MEDICINA-LITHUANIA
(2021)
Article
Endocrinology & Metabolism
Mami Okamoto, Mikio Watanabe, Naoya Inoue, Kazane Ogawa, Yoh Hidaka, Yoshinori Iwatani
Meeting Abstract
Behavioral Sciences
Shunsuke Toyoda, Satoshi Nishida, Chika Honda, Mikio Watanabe, Miina Ollikainen, Eero Vuoksimaa, Jaakko Kaprio, Shinji Nishimoto