Article
Biochemistry & Molecular Biology
Francesca Arfuso, Maria Rizzo, Claudia Giannetto, Elisabetta Giudice, Roberta Cirincione, Giovanni Cassata, Luca Cicero, Giuseppe Piccione
Summary: This study aimed to evaluate the changes in serum oxidant and antioxidant parameters, as well as the levels of homocysteine and muscle enzymes, in regularly trained athletic horses during official races of different distances. The results showed that exercise had an effect on oxidative stress markers, homocysteine, and muscle enzymes, while the race distance did not have a significant impact on these parameters.
Article
Sport Sciences
Jorge M. Gonzalez-Hernandez, Pedro Jimenez-Reyes, Jose J. Ceron, Asta Tvarijonaviciute, Francisco J. Llorente-Canterano, Luis M. Martinez-Aranda, Amador Garcia-Ramos
Summary: This study aimed to examine the agreement between serum and saliva measurements of muscle damage markers in response to an accentuated eccentric training protocol. The results showed lower values of muscle damage markers in serum compared to saliva, with a significant increase in CK in men's saliva 96 hours after training. The correlation between serum and saliva measurements was small.
JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
(2022)
Article
Food Science & Technology
Yunmei Chai, Qingwen Ma, Xin Nong, Xinyue Mu, Aixiang Huang
Summary: This study reveals that the production of phenyllactic acid (PLA) by Lactiplantibacillus plantarum L3 is regulated by the LuxS/AI-2 Quorum Sensing (QS) system, providing a theoretical basis for the efficient and large-scale production of PLA in industries in the future.
FOOD RESEARCH INTERNATIONAL
(2023)
Review
Medicine, Research & Experimental
Ziyun He, Rengqin Yan, Jinsong Liu, Haibing Dai, Yonglin Zhu, Feng Zhang, Lin Zhang, Shengkai Yan
Summary: Lactate dehydrogenase (LDH) and aspartate aminotransferase (AST) are important prognostic indicators for COVID-19 severity. A meta-analysis of 23 articles involving 4,342 patients showed that LDH and AST levels were significantly higher in patients with severe COVID-19 compared to non-severe cases. These findings suggest a correlation between LDH and AST levels and the severity of COVID-19, providing valuable insights for risk-stratified care strategies.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Correction
Dentistry, Oral Surgery & Medicine
Prem K. Sreenivasan, Veera Venkata Prasad Kakarla, Shweta Sharda, Yogitha Setty
Summary: Some corrections were noted for the original version of this article.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Neurosciences
Jens Andersen, Kia H. Markussen, Emil Jakobsen, Arne Schousboe, Helle S. Waagepetersen, Paul A. Rosenberg, Blanca Aldana
Summary: Glutamate plays a crucial role in brain function, with its recycling dependent on metabolic collaboration between neurons and astrocytes. In addition to its involvement in brain energy metabolism, glutamate also serves as a hub connecting glucose and amino acid metabolism, disruptions in which can lead to neuronal excitotoxicity. Understanding the regulation of glutamate-dependent metabolic processes may provide new insights and targets for treating neurodegenerative diseases.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jun Chen, Edward P. Hackett, Zoltan Kovacs, Craig R. Malloy, Jae Mo Park
Summary: This study evaluates the use of hyperpolarized [1-C-13]-l-lactate to detect hepatic pyruvate carboxylase activity in vivo under different nutritional states. The results show that [1-C-13]aspartate can serve as a sensitive biomarker of pyruvate carboxylase flux and can be monitored in vivo at 3 Tesla. The ratio of [1-C-13]aspartate to [C-13]HCO3- reflects the activities of pyruvate carboxylase and pyruvate dehydrogenase enzymes.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Multidisciplinary Sciences
Simone Nardin Weis, Jaques Miranda F. Souza, Juliana Bender Hoppe, Marina Firmino, Manfred Auer, Nassim N. Ataii, Leonardo Assis da Silva, Mariana Maier Gaelzer, Caroline Peres Klein, Alan R. Mol, Consuelo M. R. de Lima, Diogo Onofre Souza, Christianne G. Salbego, Carlos Andre O. Ricart, Wagner Fontes, Marcelo Valle de Sousa
Summary: Research has shown that there are fundamental sex-related differences in the proteome of organotypic hippocampal slice culture, with females exhibiting a greater prevalence of astrocytic metabolism and males showing significant neuronal metabolism. These differences manifest in preferences for glucose use, mitochondrial respiration subunits, and lipid metabolism between the sexes.
SCIENTIFIC REPORTS
(2021)
Review
Plant Sciences
Ousmane Dao, Franziska Kuhnert, Andreas P. M. Weber, Gilles Peltier, Yonghua Li-Beisson
Summary: This review discusses the functions of malate shuttles in various biological processes and emphasizes recent research findings and the similarities and differences in different organisms, providing an evolutionary perspective on redox trafficking in photosynthetic eukaryotes.
TRENDS IN PLANT SCIENCE
(2022)
Article
Medicine, Research & Experimental
Akifumi Kuwano, Miho Kurokawa, Motoyuki Kohjima, Koji Imoto, Shigeki Tashiro, Hideo Suzuki, Masatake Tanaka, Seiji Okada, Masaki Kato, Yoshihiro Ogawa
Summary: Microcirculatory disturbance plays a key role in the pathogenesis of acute liver injury (ALI), as demonstrated in this study on patients with ALI and mouse models. Monitoring the serum ALT/LDH ratio aids in identifying ALI patients with intrahepatic hypoxia due to microcirculatory disturbance, providing insights into the pathogenesis of ALI and offering a novel therapeutic strategy against ALI caused by sinusoidal hypercoagulation.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Oncology
Teng Zhu, Qinqin Han, Xiaoxiao Zhang, Qiuzhong Hou
Summary: The combination of Xinnaoning and trimetazidine significantly improves cardiac function and serum cardiac enzyme levels, lowers lipid levels, and enhances the quality of life in patients with myocardial ischemia.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Yongjiang Li, Yangxun Pan, Ximeng Lin, Jingyu Hou, Zili Hu, Li Xu, Zhongguo Zhou, Yaojun Zhang, Minshan Chen, Dandan Hu
Summary: The modified HCC-GRIm-Score system demonstrated superior predictive ability in identifying HCC patients who may benefit from ICIs therapies compared to the original GRIm-Score and the BCLC staging system, with a higher area under curve of 0.719.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Engineering, Biomedical
Sarah Schettle, Andrew Rosenbaum, Daniel Goodman, John Stulak
Summary: This study found that AST, LDH, and DRA are closely associated with clot formation in LVADs. DRA can be a potential screening biomarker for hemolysis and device thrombosis in stable LVAD patients.
Article
Chemistry, Medicinal
Fatma Guesmi, Manel Ben Ali, Ramla Ben Mouhoub, Amor Hedfi, Mohammad S. Al-Harbi, Ahmed Landoulsi
Summary: The ethnobotanical study and biological activity of Teucrium alopecurus in Tunisia is limited. This study showed the potential of TAlp in inhibiting hepatic damage induced by LPS. The anti-proliferative effects of TAlp on colon tumor cell lines and its ability to suppress inflammation in liver cells were significant.
PHARMACOGNOSY MAGAZINE
(2021)
Article
Oncology
Takeshi Hatanaka, Atsushi Naganuma, Atsushi Hiraoka, Toshifumi Tada, Masashi Hirooka, Kazuya Kariyama, Joji Tani, Masanori Atsukawa, Koichi Takaguchi, Ei Itobayashi, Shinya Fukunishi, Kunihiko Tsuji, Toru Ishikawa, Kazuto Tajiri, Hironori Ochi, Satoshi Yasuda, Hidenori Toyoda, Chikara Ogawa, Takashi Nishimura, Noritomo Shimada, Kazuhito Kawata, Hisashi Kosaka, Satoru Kakizaki, Takaaki Tanaka, Hideko Ohama, Kazuhiro Nouso, Asahiro Morishita, Akemi Tsutsui, Takuya Nagano, Norio Itokawa, Tomomi Okubo, Taeang Arai, Michitaka Imai, Yohei Koizumi, Shinichiro Nakamura, Masaki Kaibori, Hiroko Iijima, Yoichi Hiasa, Takashi Kumada
Summary: This study demonstrates that the HCC-GRIm score serves as a novel prognostic score for HCC patients treated with Atez/Bev, with a high score being associated with unfavorable prognosis in terms of disease progression and overall survival.
Article
Hematology
Ava Diarra, Nicolas Duployez, Elise Fournier, Claude Preudhomme, Valerie Coiteux, Leonardo Magro, Bruno Quesnel, Mael Heiblig, Pierre Sujobert, Fiorenza Barraco, Marie Balsat, Quentin Scanvion, Eric Hachulla, David Launay, Ibrahim Yakoub-Agha, Louis Terriou
Summary: VEXAS syndrome is caused by somatic mutations in the UBA1 gene. Patients with VEXAS syndrome often display late-onset autoinflammatory symptoms and hematologic abnormalities. Allogeneic hematopoietic stem cell transplantation (ASCT) has shown promising outcomes in some patients, but further clinical trials are needed to determine its efficacy and place in the treatment arsenal for VEXAS syndrome.
Article
Immunology
Sarah Stabler, Catherine Lamblin, Sacha Gaillard, Nicolas Just, Mirela Mihailescu, Nathalie Viget, Thierno Sy Ndiaye, Arnaud Dzeing Ella, Guillaume Brunin, Pierre Weyrich, Anne Prevotat, Cecile Chenivesse, Olivier Le Rouzic, Geoffrey Mortuaire, Fanny Vuotto, Karine Faure, Amelie Leurs, Frederic Wallet, Caroline Loiez, Marie Titecat, Remi R. Le Guern, Eric Hachulla, Sebastien Sanges, Etienne N. Nicolas, Louis Terriou, David Launay, Benjamin Lopez, Mathilde Bahuaud, Frederic Batteux, Sylvain Dubucquoi, Cyrielle Gesquiere-Lasselin, Myriam Labalette, Guillaume Lefevre
Summary: This study aimed to evaluate a systematic research strategy for the diagnosis of specific polysaccharide antibody deficiency (SPAD) in adults with unexplained bacterial infections. The results showed that SPAD is the most common immunodeficiency in adults with recurrent and/or severe bacterial infections, and should be screened in these patients.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Environmental Sciences
Madjid Djouina, Cecile Vignal, Alexandre Dehaut, Segolene Caboche, Nell Hirt, Christophe Waxin, Charlotte Himber, Delphine Beury, David Hot, Laurent Dubuquoy, David Launay, Guillaume Duflos, Mathilde Body-Malapel
Summary: The aim of this study was to investigate the effects of intestinal exposure to polyethylene (PE) microplastics on gut homeostasis. Mice were orally exposed to PE microbeads of two different sizes, and it was found that ingestion of PE microbeads led to intestinal disturbances and significant alterations of crucial intestinal markers. This highlights the need for further research on the health impact of microplastic exposure in humans.
ENVIRONMENTAL RESEARCH
(2022)
Correction
Immunology
Sebastien Sanges, Nicolas Germain, Stephane Vignes, David Seguy, Sarah Stabler, Nicolas Etienne, Louis Terriou, David Launay, Eric Hachulla, Damien Huglo, Sylvain Dubucquoi, Myriam Labalette, Guillaume Lefevre
JOURNAL OF CLINICAL IMMUNOLOGY
(2023)
Article
Rheumatology
Yann Nguyen, Cecile M. Yelnik, Nathalie Morel, Romain Paule, Romain Stammler, Leo Placais, Karim Sacre, Bertrand Godeau, Helene Maillard, David Launay, Sandrine Morell-Dubois, Anastasia Dupre, Guillaume Lefevre, Cecile Devloo, Virginie Dufrost, Ygal Benhamou, Herve Levesque, Gaelle Leroux, Jean-Charles Piette, Luc Mouthon, Eric Hachulla, Marc Lambert, Veronique Le Guern, Nathalie Costedoat-Chalumeau
Summary: This study used unsupervised clustering analysis to identify four homogeneous phenotypic subgroups among APS patients, primarily involving venous, arterial, SLE or other autoimmune disease-associated, and arterial microthrombotic phenotypes. These findings may be explained by heterogeneous pathophysiological mechanisms.
Article
Rheumatology
Sebastien Sanges, Lisa Rice, Ly Tu, Eleanor Valenzi, Jean-Luc Cracowski, David Montani, Julio C. Mantero, Camille Ternynck, Guillemette Marot, Andreea M. Bujor, Eric Hachulla, David Launay, Marc Humbert, Christophe Guignabert, Robert Lafyatis
Summary: This study examined the serum proteome of patients with systemic sclerosis-associated pulmonary arterial hypertension (SSc-PAH) and identified two proteins that were significantly correlated with pulmonary vascular resistance (PVR), potentially providing biomarkers for earlier diagnosis and treatment.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Respiratory System
J. Le Pavec, D. Launay, V. Cottin, M. Reynaud-Gaubert
REVUE DES MALADIES RESPIRATOIRES
(2023)
Article
Rheumatology
Benjamin Chaigne, Kevin Chevalier, Athenais Boucly, Christian Agard, Antoine Baudet, Arnaud Bourdin, Celine Chabanne, Vincent Cottin, Pierre Fesler, Francois Goupil, Patrick Jego, David Launay, Herve Levesque, Arnaud Maurac, Shirine Mohamed, Cecile Tromeur, Laurence Rottat, Olivier Sitbon, Marc Humbert, Luc Mouthon
Summary: Objective of this study was to describe PAH in well-characterized MCTD patients. Results showed that pericarditis, polyarthritis, thrombocytopenia, ILD and anti-Sm antibodies were independent predictive factors of PAH in MCTD. Survival rates of MCTD-PAH patients did not differ from SLE-PAH and SSc-PAH patients. Tobacco exposure was an independent predictor of mortality in MCTD-PAH.
Article
Medicine, General & Internal
Aurore Collet, Christophe Zawadzki, Emmanuelle Jeanpierre, Caroline Kitel, Sylvain Dubucquoi, Eric Hachulla, Sophie Susen, David Launay
Summary: Systemic sclerosis (SSc) is associated with endothelial activation and fibrosis. Non-O blood group is linked to higher risk of thrombosis, fibrosis and autoimmune diseases. The distribution of ABO groups in SSc patients is similar to the general population, but non-O groups are associated with inflammation and endothelial activation, and a slightly higher frequency of pulmonary and vascular complications in SSc.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
D. Launay, L. Bouillet, I. Boccon-Gibod, B. Trumbic, D. Gobert, O. Fain
Summary: Hereditary angioedema is a rare disease characterized by recurrent attacks of noninflammatory edema. It can be life-threatening and significantly affect quality of life. The usual treatments for mast cell-mediated angioedema do not work for this condition. Treatment options include selective B2 bradykinin receptor antagonist or C1 inhibitor concentrate for severe attacks, and the use of attenuated androgen or C1 inhibitor concentrate for short-term prophylaxis. Recently available kallikrein inhibitors are an important advancement in long-term prophylaxis of hereditary angioedema attacks.
REVUE DE MEDECINE INTERNE
(2023)
Review
Medicine, General & Internal
T. Penet, M. R. Pokeerbux, S. Morell-Dubois, S. Sanges, H. Maillard, E. Ledoult, M. Lambert, C. Yelnik, V. Sobanski, D. Launay, E. Hachulla, M. M. Farhat
Summary: This study presents two cases of giant-cell arteritis with coronaritis and provides a review on this complication.
REVUE DE MEDECINE INTERNE
(2023)
Article
Health Care Sciences & Services
Quentin Ducrocq, Laurence Guedon-Moreau, David Launay, Louis Terriou, Sandrine Morell-Dubois, Helene Maillard, Guillaume Lefevre, Vincent Sobanski, Marc Lambert, Cecile Yelnik, Meryem-Maud Farhat, Maria Jose Garcia Fernandez, Eric Hachulla, Sebastien Sanges
Summary: Rare disease referral centres face challenges in clinical expertise and research activities, which can be overcome with telemedicine. Tele-expertise could generate a potential weekly income of EUR 500, while teleconsultations can address the limitation of frequent visits in research activities. Telemedicine has become a conventional follow-up modality for patients with rare diseases.
Article
Environmental Sciences
Madjid Djouina, Christophe Waxin, Segolene Caboche, Karine Lecointe, Alexander Steimle, Delphine Beury, Mahesh S. Desai, David Hot, Laurent Dubuquoy, David Launay, Cecile Vignal, Mathilde Body-Malapel
Summary: Oral exposure to DON mycotoxin exacerbates the development of enteritis and colitis-associated colorectal cancer in mice, even at low doses. The results suggest that DON, at concentrations currently tolerated in the human diet, could promote the development of intestinal inflammatory diseases and colorectal cancer.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Rheumatology
Amelie Nicolas, Sylvie Leroy, Luc Mouthon, Yurdagul Uzunhan, Vincent Cottin, Arsene Mekinian, Viviane Queyrel, Eric Hachulla, Benoit Gachet, David Launay, Nihal Martis
Summary: This study provides an overview of the diagnostic approaches, follow-up, and treatment strategies used in France for the management of SSc-associated ILD. The results highlight the heterogeneity and gaps in current clinical practices, calling for improvement and standardization.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Antoine Dupont, Vincent Koether, Julien Labreuche, Paul Felloni, Thierry Perez, Pascal de Groote, Jacques Remy, Alain Duhamel, Eric Hachulla, David Launay, Martine Remy-Jardin
Summary: Dual-energy CT lung perfusion provides complementary information in systemic sclerosis patients, depicting perfusion changes in patients with normal or minimally infiltrated lung parenchyma.
EUROPEAN RADIOLOGY
(2023)
