Article
Neurosciences
Elijah Mak, Maria-Eleni Dounavi, Audrey Low, Stephen F. Carter, Elizabeth McKiernan, Guy B. Williams, P. Simon Jones, Isabelle Carriere, Graciela Terrera Muniz, Karen Ritchie, Craig Ritchie, Li Su, John T. O'Brien
Summary: This study found that a shorter estimated years to onset of dementia may be associated with incipient brain abnormalities in cognitively normal midlife adults, particularly among APOE-epsilon 4 carriers. The research also suggests that EYO could serve as a potential stage marker of preclinical progression in sporadic dementia.
Review
Clinical Neurology
Gargi Banerjee, John Collinge, Nick C. Fox, Tammaryn Lashley, Simon Mead, Jonathan M. Schott, David J. Werring, Natalie S. Ryan
Summary: Cerebral amyloid angiopathy (CAA) is a significant cerebral small vessel disease that is associated with brain haemorrhage and cognitive change. While the common form affects individuals in mid- to later life, rare early-onset forms are increasingly recognized and may be caused by genetic or iatrogenic factors. This review provides an overview of the causes of early-onset CAA and proposes a structured approach for investigation and management, aiming to raise awareness among healthcare professionals.
Article
Neurosciences
Monica Margoni, Davide Poggiali, Sofia Zywicki, Martina Rubin, Andrea Lazzarotto, Silvia Franciotta, Maria Giulia Anglani, Francesco Causin, Francesca Rinaldi, Paola Perini, Massimo Filippi, Paolo Gallo
Summary: The study found that atrophy in the red nucleus in early relapse-onset MS patients is associated with cerebellar and midbrain white matter lesions, possibly due to anterograde axonal degeneration starting from these regions. This suggests that RN atrophy could serve as a potential marker for neurodegeneration or cerebellar damage in RMS.
HUMAN BRAIN MAPPING
(2021)
Article
Clinical Neurology
Percy Griffin, Liana Apostolova, Bradford C. Dickerson, Gil Rabinovici, Stephen Salloway, Katie Brandt, Joseph Masdeu, Dustin Hammers, Srilatha Raghuram, Stephen Hall, Maria C. Carrillo
Summary: The Alzheimer's Association hosted a meeting focusing on individuals with early-onset Alzheimer's disease (EOAD) or younger onset Alzheimer's disease (AD) on September 25 and 26, 2021. This meeting aimed to provide information on the latest research, treatments, legal and financial considerations, and support networks for individuals with EOAD and their families. The Longitudinal Early-Onset Alzheimer's Disease Study (LEADS) was also introduced as a research project to enroll and follow 500 people with EOAD from various sites in the United States.
ALZHEIMERS & DEMENTIA
(2023)
Article
Psychiatry
Reza Moshfeghinia, Bahare Oji, Mehrnaz Hosseinzadeh, Mohammad Pourfridoni, Jamshid Ahmadi
Summary: This article describes a case of Frontotemporal dementia (FTD) caused by marijuana abuse, highlighting the profound impact of cannabis consumption on brain structure and chemistry, including the potential for neurodegenerative disorders like FTD.
Review
Clinical Neurology
Alexandra Touroutoglou, Yuta Katsumi, Michael Brickhouse, Alexander Zaitsev, Ryan Eckbo, Paul Aisen, Laurel Beckett, Jeffrey L. Dage, Ani Eloyan, Tatiana Foroud, Bernardino Ghetti, Percy Griffin, Dustin Hammers, Clifford R. Jack, Joel H. Kramer, Leonardo Iaccarino, Renaud La Joie, Nidhi S. Mundada, Robert Koeppe, Walter A. Kukull, Melissa E. Murray, Kelly Nudelman, Angelina J. Polsinelli, Malia Rumbaugh, David N. Soleimani-Meigooni, Arthur Toga, Prashanthi Vemuri, Alireza Atri, Gregory S. Day, Ranjan Duara, Neill R. Graff-Radford, Lawrence S. Honig, David T. Jones, Joseph C. Masdeu, Mario F. Mendez, Erik Musiek, Chiadi U. Onyike, Meghan Riddle, Emily Rogalski, Stephen Salloway, Sharon Sha, R. Scott Turner, Thomas S. Wingo, David A. Wolk, Kyle Womack, Maria C. Carrillo, Gil D. Rabinovici, Liana G. Apostolova, Bradford C. Dickerson, LEADS Consortium
Summary: MRI research has advanced understanding of neurodegeneration in sporadic early-onset Alzheimer's disease, with the EOAD-signature atrophy replicated across different cohorts and associated with the severity of cognitive impairment. This suggests that EOAD-signature atrophy could be a reliable biomarker for AD-related neurodegeneration in clinical trials for EOAD.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Annalisa Chiari, Giulia Vinceti, Giorgia Adani, Manuela Tondelli, Chiara Galli, Luigi Fiondella, Manuela Costa, Maria A. Molinari, Tommaso Filippini, Giovanna Zamboni, Marco Vinceti
Summary: Research investigated the epidemiology of EOD by identifying patients in the extended network of dementia services in Modena province, Northern Italy. The incidence of EOD in the 30-64 age group was 13.2 per 100,000/year, with a prevalence of 74.3 per 100,000 on June 30, 2019. The most common phenotypes were the amnestic variant of AD and the behavioral variant of FTD.
ALZHEIMERS & DEMENTIA
(2021)
Article
Clinical Neurology
Federico Marrama, Maeva Kyheng, Marco Pasi, Matthieu Pierre Rutgers, Solene Moulin, Marina Diomedi, Didier Leys, Charlotte Cordonnier, Hilde Henon, Barbara Casolla
Summary: This study found a high incidence of early-onset delirium in patients with spontaneous intracerebral hemorrhage, which is associated with markers of pre-existing brain vulnerability. Predictors of early-onset delirium included pre-existing dementia, heavy alcohol intake, and lobar location of intracerebral hemorrhage. Early-onset delirium was associated with higher mortality rates, but did not predict higher dementia rates during long-term follow-up.
INTERNATIONAL JOURNAL OF STROKE
(2022)
Article
Neurosciences
Somayeh Meysami, Cyrus A. Raji, Mario F. Mendez
Summary: Volumetric quantification of brain MR imaging can help differentiate between behavioral variant frontotemporal dementia (bvFTD) and early-onset Alzheimer's disease (EOAD). bvFTD patients had lower volume in frontal lobes, thalamus, and putamen, while EOAD patients had lower volume in the parietal lobe. The use of Neuroreader percentiles resulted in 99.3% accuracy, while the use of subfields resulted in 80.2% accuracy. The parietal lobe volume was the most predictive factor.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Clinical Neurology
Valeria Isella, Daniele Licciardo, Giulia Nastasi, Valentina Impagnatiello, Francesca Ferri, Cristina Mapelli, Cinzia Crivellaro, Monica Musarra, Sabrina Morzenti, Ildebrando Appollonio, Carlo Ferrarese
Summary: Late-onset and early-onset dementia exhibit neurobiological and clinical differences. This study compared the clinical and FDG-PET features of posterior cortical atrophy (PCA), the visual variant of Alzheimer's disease, between late-onset and early-onset cases. The results showed that the main difference between the two groups was a higher prevalence of Balint-Holmes symptoms in the early-onset cases, which was associated with severe bilateral occipito-temporo-parietal hypometabolism. In the late-onset cases, there was a reduction of FDG uptake mainly in the right posterior regions. Age was found to be correlated with metabolism in different brain regions.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Review
Medicine, General & Internal
Martin Nwadiugwu
Summary: People with early-onset dementia are at risk of marginalisation due to blame and stigma associated with their condition, leading to limited access to care and social support. Relationship-centred care approaches such as early diagnosis, behavioural therapies, Montessori activities, and community services tailored to their needs can help improve their situation and support their caregivers.
POSTGRADUATE MEDICAL JOURNAL
(2021)
Article
Clinical Neurology
Jonathan D. Santoro, Peter K. Moon, Michelle Han, Emily S. McKenna, Elizabeth Tong, Sarah J. MacEachern, Nils D. Forkert, Kristen W. Yeom
Summary: Individuals with medically refractory migraine headache show significant changes in apparent diffusion coefficient in multiple brain structures, suggesting structural connectivity issues may predispose some patients to more medically refractory pain disorders such as migraine headache. Volumetric differences were not observed between the two groups.
FRONTIERS IN NEUROLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Maria Edvige Giannone, Tommaso Filippini, Paul K. Whelton, Annalisa Chiari, Marco Vitolo, Giuseppe Boriani, Marco Vinceti
Summary: This study investigates the relationship between atrial fibrillation (AF) and early-onset dementia. The findings suggest that AF is a risk factor for dementia in adults under the age of 70, with a slight and statistically imprecise excess risk even at younger ages (<65 years). Further research is needed to understand the specific characteristics and mechanisms involved in this relationship.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Psychiatry
Manuela Tondelli, Chiara Galli, Giulia Vinceti, Luigi Fiondella, Simone Salemme, Chiara Carbone, Maria Angela Molinari, Annalisa Chiari, Giovanna Zamboni
Summary: Anosognosia levels were not significantly different between early-onset dementia (EOD) and late-onset dementia (LOD) patients, but increased with disease progression, especially in frontotemporal dementia cases. Early anosognosia was associated with higher frequency and severity of subsequent neuropsychiatric symptoms.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Clinical Neurology
Jose Contador, Agnes Perez-Millan, Nuria Guillen, Jordi Sarto, Adria Tort-Merino, Mircea Balasa, Neus Falgas, Magdalena Castellvi, Sergi Borrego-Ecija, Jordi Junca-Parella, Beatriz Bosch, Guadalupe Fernandez-Villullas, Oscar Ramos-Campoy, Anna Antonell, Nuria Bargallo, Raquel Sanchez-Valle, Roser Sala-Llonch, Albert Llado
Summary: Sex differences exist in cognitive impairment, atrophy burden, and CSF tau levels in early-onset Alzheimer's disease, with female patients showing worse symptoms.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Anatomy & Morphology
Christophe Destrieux, Louis Marie Terrier, Frederic Andersson, Scott A. Love, Jean-Philippe Cottier, Henri Duvernoy, Stephane Velut, Kevin Janot, Ilyess Zemmoura
BRAIN STRUCTURE & FUNCTION
(2017)
Article
Neurosciences
Maelle Dejobert, Xavier Cazals, Mariam Annan, Severine Debiais, Marie-Agnes Lauvin, Jean-Philippe Cottier
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2016)
Article
Neurosciences
Stefan J. Teipel, Enrica Cavedo, Michel J. Grothe, Simone Lista, Samantha Galluzzi, Olivier Colliot, Marie Chupin, Hovagim Bakardjian, Didier Dormont, Bruno Dubois, Harald Hampel
Article
Neurosciences
Maelle Dejobert, Xavier Cazals, Mariam Annan, Severine Debiais, Marie-Agnes Lauvin, Jean-Philippe Cottier
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2016)
Letter
Medicine, General & Internal
Julien Le Marec, Stephanie Jobard, Adrien Bigot, Benjamin Terrier, Jean-Philippe Cottier, Frederic Bastides, Elisabeth Diot
JOURNAL OF KOREAN MEDICAL SCIENCE
(2017)
Article
Multidisciplinary Sciences
Lobna Ouldamer, Caroline Goupille, Anne Vilde, Flavie Arbion, Gilles Body, Stephan Chevalier, Jean Philippe Cottier, Philippe Bougnoux
Article
Multidisciplinary Sciences
Guillaume Marzolf, Marcela Sabou, Beatrice Lannes, Francois Cotton, David Meyronet, Damien Galanaud, Jean-Philippe Cottier, Sylvie Grand, Hubert Desal, Julie Kreutz, Maleka Schenck, Nicolas Meyer, Francis Schneider, Jean-Louis Dietemann, Meriam Koob, Raoul Herbrecht, Stephane Kremer
Article
Clinical Neurology
A. Lecler, J. Bailleux, B. Carsin, H. Adle-Biassette, S. Baloglu, C. Bogey, F. Bonneville, E. Calvier, P-O. Comby, J-P. Cottier, F. Cotton, R. Deschamps, C. Diard-Detoeuf, F. Ducray, L. Duron, C. Drissi, M. Elmaleh, J. Farras, J. A. Garcia, E. Gerardin, S. Grand, D. C. Jianu, S. Kremer, N. Magne, M. Mejdoubi, A. Moulignier, M. Ollivier, S. Nagi, M. Rodallec, J-C. Sadik, N. Shor, T. Tourdias, C. Vandendries, V. Broquet, J. Savatovsky
AMERICAN JOURNAL OF NEURORADIOLOGY
(2019)
Article
Clinical Neurology
Maxence Serru, Benedicte Marechal, Tobias Kober, Leo Ribier, Catherine Sembely Taveau, Dominique Sirinelli, Jean-Philippe Cottier, Baptiste Morel
Summary: This study aimed to evaluate inter-radiologist reliability in brain MRI interpretation in pediatric population and the efficiency of automated brain segmentation. Results showed that brain volume abnormalities were poorly detected by radiologists, but easier to identify with automated quantification.
JOURNAL OF NEURORADIOLOGY
(2021)
Editorial Material
Infectious Diseases
Sandra Obry, Raoul Kanav Khanna, Marion Lacasse, Kevin Reffet, Jean-Philippe Cottier, Adelaide Chesnay, Clara Cohen
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Engineering, Biomedical
P. Dequidt, P. Bourdon, B. Tremblais, C. Guillevin, B. Gianelli, C. Boutet, J-P Cottier, J-N Vallee, C. Fernandez-Maloigne, R. Guillevin
Summary: This study aims to train a binary grade classifier and investigate the consistency of original BraTS labels with radiologic criteria using machine-aided predictions. The results show the coherence of radiologic criteria for low grade versus high grade classification under WHO terms, and demonstrate how prediction scores and crossed prediction scores can be used as tools for data exploration and performance evaluation. The proposed radiological groundtruth could be used for future development on binary glioma grading.
Article
Otorhinolaryngology
Thuy-Tran Trinh, C. Cohen, L. Boullaud, J. P. Cottier, David Bakhos
Summary: This study evaluated the use of a sheep head model for neuroradiologic assessment and surgical implantation of a cochlear implant electrode array. The results showed that sheep are a realistic animal model for training cochlear implant surgery and obtaining perilymph samples, but may not be ideal for mastoidectomy training due to mastoid pneumatization.
BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY
(2022)
Article
Clinical Neurology
Clara Cohen, Kathleen Gaillot, Heloise Ifergan, Maelle Dejobert, Marie Gaudron, Elisabeth Molinier, Aymeric Amelot, Jean -Philippe Cottier, Richard Bibi, Kevin Janot, Christophe Magni, Ana-Paula Narata, Gregoire Boulouis
Summary: The aim of this study was to evaluate the impact of quantitatively assessed thrombus migration (T-Mig) on clinical outcomes in patients with acute ischemic stroke and large vessel occlusion. The study found that thrombus migration was common in this patient population, but it did not have a significant association with clinical outcome.
JOURNAL OF NEURORADIOLOGY
(2022)
Article
Clinical Neurology
J. Rhein, G. Charbonnier, M. Nacher, M. Gaudron, T. Moulin, D. R. Rochemont, J. -P. Cottier, C. Montagnac, N. Sabbah, B. de Toffol
Summary: This study compared the epidemiological characteristics, acute phase management, discharge scores and treatment of stroke patients in French Guiana and mainland France. Stroke patients in French Guiana had a lower average age, higher proportion of lacunar strokes and lower proportion of cardioembolic infarctions. There were differences in acute phase management and discharge method between the two regions.
REVUE NEUROLOGIQUE
(2023)
Article
Dermatology
L. Chaput, N. Rabot, N. Limousin, J. -P. Cottier, B. Lioger, M. Samimi
ANNALES DE DERMATOLOGIE ET DE VENEREOLOGIE
(2017)
