Article
Neurosciences
David R. Miller, Ramsey Ashour, Colin T. Sullender, Andrew K. Dunn
Summary: This study demonstrates the ability of LSCI to continuously visualize blood flow during neurovascular procedures and provides different yet complementary information compared to ICGA.
Article
Optics
David Shemesh, Ohad Aburus, Gadi Turgeman, David Bookasis
Summary: The study evaluated the use of laser irradiation as a therapeutic intervention for traumatic brain injury, showing that high doses of laser irradiation can attenuate the severity of brain damage. By monitoring brain hemodynamics and metabolic responses, it was confirmed that laser therapy can effectively inhibit the development of complications.
OPTICS AND LASER TECHNOLOGY
(2022)
Article
Engineering, Biomedical
Ximeng Feng, Mufeng Geng, Xiangxi Meng, Da Zou, Zi Jin, Gangjun Liu, Chuanqing Zhou, Qiushi Ren, Yanye Lu
Summary: Hemodynamics imaging of the retinal microcirculation has potential value in evaluating ophthalmic diseases, cardio-cerebrovascular diseases, and metabolic diseases. However, existing imaging techniques lack sufficient spatial or temporal resolution. The proposed sphygmus gated laser speckle angiography (SGLSA) offers high spatiotemporal resolution for structural and functional imaging. Compared to classic LSCI algorithms, SGLSA provides clearer perfusion images and higher signal-to-noise ratio pulsatility. The algorithm also shows better performance on patients than traditional methods, greatly enhancing the ability of retinal microcirculation analysis and holding significant importance for retinal hemodynamic imaging, biomarker research, and clinical diagnosis.
COMPUTERIZED MEDICAL IMAGING AND GRAPHICS
(2023)
Article
Chemistry, Analytical
Youngkyu Kim, Woo June Choi, Jeongmin Oh, Kwanhee Lee, Jun Ki Kim
Summary: Modern smartphones are being used in point-of-care devices due to their advanced form factor, computing, and display performances.With dual-wavelength laser speckle contrast imaging, a smartphone-combined handheld endoscope is developed to monitor blood flow changes and hemoglobin concentration in real-time. The combination of LSCI with smartphone endoscopy offers a valuable platform for understanding the functional hemodynamic changes in internal organs, which can benefit the diagnosis and treatment of vascular diseases in point-of-care testing.
Article
Optics
Stefan Steinhauser, Ehsan Fattahi, Dominik Geier, Thomas Becker
Summary: Laser Speckle Rheology (LSR) is an optical technology used for non-invasive evaluation of a material's rheological properties. This paper proposes a method to correct non-ideal speckle patterns using a diode laser instead of the traditional He-Ne laser. Experimental results show that the corrected speckle patterns acquired with the diode laser are comparable to those acquired with the He-Ne laser.
OPTICS AND LASER TECHNOLOGY
(2022)
Article
Biochemical Research Methods
Colin T. Sullender, Adam Santorelli, Lisa M. Richards, Pawan K. Mannava, Christopher Smith, Andrew K. Dunn
Summary: This study evaluated the uncertainty in flow generation for a syringe pump and a pressure-regulated flow system in a microfluidic environment, and assessed the performance of laser speckle contrast imaging (LSCI) and multi-exposure speckle imaging (MESI). The results showed that the pressure-regulated flow system produced more stable and reliable flow outputs compared to the syringe pump. MESI achieved more accurate flow measurements than LSCI across a range of flow speeds. Therefore, pressure-regulated flow systems should be used for assessing flow measurement techniques in microfluidic studies.
JOURNAL OF BIOMEDICAL OPTICS
(2023)
Article
Engineering, Biomedical
Nadezhda Golubova, Elena Potapova, Evgeniya Seryogina, Viktor Dremin
Summary: Improving noninvasive approaches to monitoring blood microcirculation is an urgent topic in modern biomedical engineering. One of the actively developing methods is laser speckle contrast imaging (LSCI), which allows for the visualization and quantitative measurements of microcirculatory blood flow. The study demonstrates the application of LSCI for mapping cerebral vessels in a laboratory animal and introduces time-frequency processing of the registered signal. This technological advancement expands the capabilities of LSCI and enables detailed analysis of the physiological mechanisms of changes in blood flow.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2023)
Article
Surgery
Sicai Tao, Tingbao Zhang, Keyao Zhou, Xiaohu Liu, Yu Feng, Wenyuan Zhao, Jincao Chen
Summary: This study investigates the use of intraoperative laser speckle contrast image (LSCI) software in assessing cerebral perfusion during brain arteriovenous malformations (bAVM) surgery. The results show that LSCI can visualize and evaluate cortical cerebral blood flow in real-time, allowing for the detection of pathological hyperperfusion. This non-invasive and cost-effective method provides important information for the resection of AVM in the hybrid operative room.
FRONTIERS IN SURGERY
(2022)
Article
Chemistry, Analytical
Youngkyu Kim, Woo June Choi, Jungmin Oh, Jun Ki Kim
Summary: Laser speckle contrast imaging (LSCI) is a powerful tool for quantifying blood flow. Recent advancements in smartphone and camera technologies have made them suitable for point-of-care (POC) diagnosis using LSCI. A portable LSCI endoscope system, based on a smartphone, was validated for diagnosing vascular disorders and showed potential for preclinical applications.
Article
Neurosciences
Lu Yin, Tengfei Yu, Linggang Cheng, Xinyao Liu, Wei Zhang, Hongxia Zhang, Lijuan Du, Wen He
Summary: This study used laser speckle contrast imaging to monitor cerebral cortical blood flow changes during CIRI in mice and found a correlation between cerebral cortical blood flow and outcome.
Article
Biochemical Research Methods
Martin Hultman, Marcus Larsson, Tomas Stromberg, Ingemar Fredriksson
Summary: Multi-exposure speckle contrast imaging (MELSCI) allows for the calculation of speed-resolved perfusion in absolute units, improving the physiological interpretation of data and increasing the clinical impact of the technique.
JOURNAL OF BIOMEDICAL OPTICS
(2023)
Article
Optics
Fenfen Xu, Chengfeng Xie, Yubao Zhang, Gang Shi, Jiulin Shi, Xiaojun Xu, Youjiang Zhao, Yirui Zhu, Xingdao He
Summary: The study compared the polarized and non-polarized laser speckle contrast imaging systems for assessing pulp blood flow. The results indicated that the vp-LSCI system could detect a wider contrast dynamic range, while the time contrast algorithm showed a higher detectability index compared to the space contrast algorithm.
JOURNAL OF MODERN OPTICS
(2021)
Article
Biochemical Research Methods
Chang Liu, Kivilcim Kilic, Sefik Evren Erdener, David A. Boas, Dmitry D. Postnov
Summary: Laser speckle contrast imaging (LSCI) is a real-time full-field non-invasive technique widely used in visualizing blood flow in biomedical applications. Critical assumptions in LSCI theory were reviewed, and it was shown how they can impact the accuracy of blood flow estimation. Based on recent experimental results, an alternative model was proposed for higher accuracy in measuring blood flow changes.
BIOMEDICAL OPTICS EXPRESS
(2021)
Article
Biochemical Research Methods
Ximeng Feng, Yue Yu, Da Zou, Zi Jin, Chuanqing Zhou, Gangjun Liu, James G. Fujimoto, Changhui Li, Yanye Lu, Qiushi Ren
Summary: A novel integration of retinal multispectral imaging, retinal oximetry and laser speckle contrast imaging was presented for functional imaging of retinal blood vessels. The technology allows rapid acquisition of structural MSI images, retinal oximetry and LSCI blood flow information in a simplified clinical workflow, providing both structural and functional information on the retina.
JOURNAL OF BIOPHOTONICS
(2022)
Article
Computer Science, Information Systems
Ping Kong, Hao Xu, Ran Li, Gang Huang, Wei Liu
Summary: The utilization of smartphone camera systems for laser speckle imaging has enhanced the quality of blood flow imaging. The new speckle contrast analysis method, which involves wavelet decomposition and morphological operations, significantly improves image contrast resolution and visualization.