Review
Biochemistry & Molecular Biology
Vanessza Emmert, Dominika Lendvai-Emmert, Kata Eklics, Viktoria Premusz, Gergely Peter Toth
Summary: Cow's milk protein allergy is a common pediatric food allergy that has a significant socioeconomic impact and affects the quality of life of individuals and their families. Various immunologic pathways contribute to the clinical symptoms, with some mechanisms well-known and others requiring further research. A comprehensive understanding of food allergy development and oral tolerance could lead to improved diagnostic tools and novel therapies for cow's milk protein allergy patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Severina Terlouw, Frank E. van Boven, Monika Borsboom-van Zonneveld, Catharina de Graaf-in 't Veld, Marloes E. van Splunter, Paul L. A. van Daele, Maurits S. van Maaren, Marco W. J. Schreurs, Nicolette W. de Jong
Summary: The study compared the SPT results of homemade food allergen extracts with commercially available extracts, finding that homemade hazelnut and walnut extracts can be good alternatives in the absence of commercial extracts. The agreement between SPT results and food allergen-specific symptoms were comparable for homemade and commercial extracts, except for peach.
Article
Medicine, General & Internal
Maria Roca, Ester Donat, Ana Rodriguez Varela, Eva Carvajal, Francisco Cano, Ana Armisen, Helena Ekoff, Antonio Jose Canada-Martinez, Niclas Rydell, Carmen Ribes-Koninckx
Summary: The study aimed to evaluate fCP and fEDN as markers for diagnosing CMPA and monitoring infants' response to a CMP-free diet. However, the levels of fCP and fEDN were not able to differentiate between healthy infants and those with non-IgE-mediated CMPA, and there were no significant changes in fCP levels after a CMP-free diet in the CMPA group. Prospective studies with larger populations are needed for more robust conclusions.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Allergy
Alexandra F. Santos, Carmen Riggioni, Ioana Agache, Cezmi A. Akdis, Mubeccel Akdis, Alberto Alvarez-Perea, Montserrat Alvaro-Lozano, Barbara Ballmer-Weber, Simona Barni, Kirsten Beyer, Carsten Bindslev-Jensen, Helen A. Brough, Betul Buyuktiryaki, Derek Chu, Stefano Del Giacco, Audrey Dunn-Galvin, Bernadette Eberlein, Motohiro Ebisawa, Philippe Eigenmann, Thomas Eiwegger, Mary Feeney, Montserrat Fernandez-Rivas, Helen R. Fisher, David M. Fleischer, Mattia Giovannini, Claudia Gray, Karin Hoffmann-Sommergruber, Susanne Halken, Jonathan O'B. Hourihane, Christina J. Jones, Marek Jutel, Edward Knol, George N. Konstantinou, Gideon Lack, Susanne Lau, Andreina Marques Mejias, Mary Jane Marchisotto, Rosan Meyer, Charlotte G. Mortz, Beatriz Moya, Antonella Muraro, Caroline Nilsson, Lucila Camargo Lopes de Oliveira, Liam O'Mahony, Nikolaos G. Papadopoulos, Kirsten Perrett, Rachel L. Peters, Marcia Podesta, Lars K. Poulsen, Graham Roberts, Hugh A. Sampson, Juergen Schwarze, Peter Smith, Elizabeth Huiwen Tham, Eva Untersmayr, Ronald Van Ree, Carina Venter, Brian P. Vickery, Berber Vlieg-Boerstra, Thomas Werfel, Margitta Worm, George Du Toit, Isabel Skypala
Summary: This guideline from the European Academy of Allergy and Clinical Immunology provides recommendations for diagnosing IgE-mediated food allergy, including clinical history, tests for determining IgE sensitization, and the use of oral food challenges for confirmation.
Article
Chemistry, Applied
Angela Maria Candreva, Paola L. Smaldini, Ana Cauerhff, Silvana Petruccelli, Guillermo H. Docena
Summary: This study explored a preventive protocol for milk allergy with the oral administration of a soy-derived peptide containing cross-reactive epitopes, successfully preventing IgE-mediated milk sensitization through the induction of Th1-mediated immunity and induction of blocking IgG. This safe soy-peptide may represent a promising alternative for preventing milk allergy.
Article
Allergy
Kok Wee Chong, Si Hui Goh, Seyed Ehsan Saffari, Wenyin Loh, Isabel Sia, Sherilyn Seah, Anne Goh
Summary: Cow's milk protein allergy (CMA) is a common food allergy in infants in Singapore, with cutaneous and gastrointestinal reactions being the most common manifestations. Most patients acquire natural tolerance by 6 years old. Skin prick test and cow's milk-specific immunoglobulin E testing have good discriminative abilities in predicting failed oral food challenge outcomes.
ASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Katie D. Hunter, Robert W. E. Crozier, Jessica L. Braun, Val A. Fajardo, Adam J. MacNeil
Summary: In this study, the role of SARCA in allergen-activated mast cells was characterized. Treatment with the SARCA activating compound, CDN1163, was found to attenuate early phase mast cell degranulation, reactive oxygen species (ROS) production, and secretion of IL-6, IL-13, and CCL3. These protective effects may be driven by the suppression of p38 MAPK signaling. These findings suggest that SARCA is an important regulator of the mast cell response to allergens and may have therapeutic potential in targeting allergic pathologies.
Article
Biochemistry & Molecular Biology
Mohd Adnan Kausar, Tulika Bhardwaj, Sadaf Anwar, Fahaad Alenazi, Abrar Ali, Khalid Farhan Alshammari, Shimaa Mohammed Hasnin AboElnaga, Rajeev Singh, Mohammad Zeeshan Najm
Summary: The burden of allergic illnesses is continuously rising, making patient diagnosis challenging. This study uses in silico analysis to identify potential IgE-mediated allergens and evaluate their potential value in allergic respiratory diseases.
Article
Nutrition & Dietetics
PeiAo Zhang, Jihui Gao, Huilian Che, Wentong Xue, Dong Yang
Summary: This study constructed a chimeric IgE in silico to investigate the molecular mechanism of shrimp allergen recognition. The research found that specific amino acid residues in shrimp tropomyosin contribute to IgE-mediated immune response, and heat treatment can alter the allergenic peptides' conformations, reducing their binding to IgE and desensitizing shrimp allergens.
Article
Allergy
Jennifer Dantzer, Joan Dunlop, Kevin J. Psoter, Corinne Keet, Robert Wood
Summary: Baked milk oral immunotherapy (BMOIT) has shown safety and efficacy in treating children with baked milk allergy. After 12 months of treatment, the majority of participants in the BMOIT group were able to tolerate higher doses of baked milk protein compared to the placebo group. Dose-related adverse reactions were common but mild. BMOIT increased cow's milk-sIgG4 levels and decreased casein IgE levels.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Review
Food Science & Technology
Sabine Geiselhart, Aleksandra Podzhilkova, Karin Hoffmann-Sommergruber
Summary: Cow's milk is an essential part of our diet but can also trigger immune-mediated diseases. Allergens in cow's milk have been identified, but processing methods can impact their immunogenicity.
Review
Allergy
Pattraporn Satitsuksanoa, Monique Daanje, Mubeccel Akdis, Scott D. Boyd, Willem van de Veen
Summary: B cells play a crucial role in the development of IgE-mediated food allergies by producing allergen-specific antibodies, but the mechanisms regulating allergen-specific IgE production and immunological memory are not fully understood. Recent technological advances have allowed detailed analysis of B cells at a single-cell level, providing a better understanding of their role in food allergies.
Article
Nutrition & Dietetics
Jinya Ma, Chong Wang, Fangting Wang, Yong Zhang, Yinghua Liu, Jiachao Zhang, Zhongshan Gao, Yi Zhang, Hujun Xie, Yanbo Wang, Linglin Fu
Summary: The study found a close correlation between gut proline and serum IgE, indicating proline as a promising biomarker and potential therapeutic method for allergic diseases.
FRONTIERS IN NUTRITION
(2022)
Review
Allergy
Alessandra Arcolaci, Rocco Scarmozzino, Giovanna Zanoni
Summary: Although allergic reactions to vaccines are rare, the accurate diagnosis and management of suspected cases is crucial to avoid interruption of vaccinations and increase in preventable diseases. Most suspected allergies cannot be effectively confirmed, allowing patients to continue the vaccination schedule. Vaccine experts, such as allergists or immunologists, should assess patients at risk and perform correct procedures to ensure safe immunization.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2023)
Review
Allergy
Alessandra Arcolaci, Rocco Scarmozzino, Giovanna Zanoni
Summary: Vaccines may cause allergic reactions, although they are generally safe. Accurate diagnostic management is crucial to avoid serious reactions upon re-exposure. Expert assessment and proper procedures are necessary to ensure safe immunization practices for individuals at risk of allergic reactions.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2023)
