Review
Biochemistry & Molecular Biology
Safikur Rahman, Vijay Kumar, Anuj Kumar, Tasduq S. Abdullah, Irfan A. Rather, Arif Tasleem Jan
Summary: Breast cancer, the second leading cause of death in women, is a complex and heterogeneous type of cancer with limited treatment effectiveness. Nanomedicine, as a drug delivery module, can enhance drug targeting and stability, potentially improving clinical outcomes of breast cancer treatment.
Article
Multidisciplinary Sciences
Qianqian Bai, Yu Xiao, Huiling Hong, Xiaoyun Cao, Lei Zhang, Ruifang Han, Leo Kit Cheung Lee, Evelyn Y. Xue, Xiao Yu Tian, Chung Hang Jonathan Choi
Summary: This study demonstrates the use of a three-dimensional nanostructure for delivering therapeutic oligonucleotides to atherosclerotic plaques. The nanoparticles target specific cells in the plaques and modulate genes related to plaque formation and inflammation, resulting in reduced and stabilized plaques without severe toxicity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Nura A. Mohamed, Isra Marei, Sergio Crovella, Haissam Abou-Saleh
Summary: Cardiovascular diseases (CVDs) are major global diseases, but early and long-term outcomes vary greatly, requiring innovative approaches. Nanotechnology has potential applications in chronic diseases, particularly CVDs. Nanoparticles as drug carriers can enhance efficacy and safety, but there are controversies regarding the selection of nanomaterials and nanoformulations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Erica B. Peters, Mark R. Karver, Kui Sun, David C. Gillis, Suvendu Biswas, Tristan D. Clemons, Wenhan He, Nick D. Tsihlis, Samuel I. Stupp, Melina R. Kibbe
Summary: This study developed targeted self-assembled peptide amphiphile (PA) nanofibers that can respond to biochemical cues in atherosclerotic lesions to deliver a liver X receptor agonist (LXR) for enhancing macrophage cholesterol efflux. The PA nanofibers were shown to promote cholesterol efflux from macrophages in vitro with lower cytotoxicity, and target plaque within an atherosclerotic mouse model in vivo, demonstrating their potential for controlled therapeutic delivery to the atherosclerotic niche.
ADVANCED THERAPEUTICS
(2021)
Review
Biotechnology & Applied Microbiology
Yanyan Cao, Run Zhang
Summary: This review outlines the developments and benefits of nanomedicines in treating Alzheimer's disease (AD), highlighting the potential of nanotechnology in diagnosing and providing alternative treatments for this neurodegenerative condition. Prospective nanomedicines for diagnosing and surveillance therapeutic interventions for AD and other diseases of the central nervous system (CNS) may be clinically accessible, driving further research in this field.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Genetics & Heredity
J. P. Jose Merlin, Xiaogang Li
Summary: Nanotechnology has the potential to improve the treatment of renal disorders by enhancing the targetability and bioavailability of drugs. The use of nano-based medication delivery devices is growing in the field of kidney disease treatment. However, there are still challenges and opportunities that need to be addressed.
FRONTIERS IN GENETICS
(2022)
Article
Pharmacology & Pharmacy
Joao Paulo Assolini, Amanda Cristina Machado Carloto, Bruna Taciane da Silva Bortoleti, Manoela Daiele Goncalves, Fernanda Tomiotto Pellissier, Paulo Emilio Feuser, Arthur Poester Cordeiro, Pedro Henrique Hermes de Araujo, Claudia Sayer, Milena Menegazzo Miranda Sapla, Wander Rogerio Pavanelli
Summary: This review highlights the recent advances in nanomedicine for improving the diagnosis, treatment, and vaccine development of leishmaniasis. Nanotechnology can enhance the sensitivity and specificity of diagnostic tests as biosensors, and can also act as drug carriers to reduce toxic effects. In addition, nanomaterials can carry Leishmania antigens to produce effective vaccines.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Kunika Saini, Smriti Sharma
Summary: This paper comprehensively covers the role of nanotechnology in diagnostics and therapeutics of diabetes. The authors discuss nanoparticle-based drug delivery systems, quality evaluation parameters, and the limitations of conventional therapies overcome by nanotechnology. The paper also highlights the clearance mechanisms and toxicity concerns of nanoparticles.
JOURNAL OF NANOPARTICLE RESEARCH
(2023)
Article
Multidisciplinary Sciences
Pedro P. G. Guimaraes, Christian G. Figueroa-Espada, Rachel S. Riley, Ningqiang Gong, Lulu Xue, Tomasz Sewastianik, Peter S. Dennis, Claudia Loebel, Amanda Chung, Sarah J. Shepherd, Rebecca M. Haley, Alex G. Hamilton, Rakan El-Mayta, Karin Wang, Robert Langer, Daniel G. Anderson, Ruben D. Carrasco, Michael J. Mitchell
Summary: Multiple myeloma (MM) is a hematologic malignancy that colonizes the bone marrow and lacks effective therapies. Endothelial cells in the bone marrow microenvironment, specifically Cyclophilin A (CyPA), play a critical role in MM progression and chemotherapeutic resistance. In this study, researchers developed a nanoparticle-based approach using RNA interference (RNAi) technology to target CyPA and inhibit MM cell extravasation. The strategy demonstrated promising results in vitro and in a murine xenograft model, indicating its potential as a therapeutic strategy for MM.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Biochemistry & Molecular Biology
Sofia Miron-Barroso, Elena B. Domenech, Sonia Trigueros
Summary: Nanomaterials are being developed for gene delivery, but challenges such as low efficiency and potential toxicity need to be addressed. Advancements in nanotechnology are crucial for overcoming these limitations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Zhimin Tang, Xianqun Fan, Yu Chen, Ping Gu
Summary: The limitations of conventional therapeutic strategies in ophthalmology have led to the development of versatile alternatives based on nanosystems. This review comprehensively examines the recent progress in nanomaterials in ophthalmology and highlights their role in addressing the challenges of ocular treatments.
Review
Chemistry, Multidisciplinary
Qian Wu, Siyuan Fu, Hanyang Xiao, Jiaxin Du, Fang Cheng, Shuangshuang Wan, Houjuan Zhu, Dan Li, Fei Peng, Xianguang Ding, Lianhui Wang
Summary: Extracellular vesicles (EVs) are important cell surrogates that have wide applications in clinical diagnosis and treatment. However, the heterogeneity and small size of EVs present technical barriers to their clinical translation. This article provides a critical overview of emerging technologies in EVs field for biomedical applications, discusses the current methods for EVs isolation and identification, and presents engineering strategies for scalable production and improved cargo loading. The superior clinical potential of EVs, particularly in terms of different cell origins and their application in the next generation of diagnostic and treatment platforms, is emphasized.
Review
Biotechnology & Applied Microbiology
Paula Fernandez-Gomez, Carmen Perez de la Lastra Aranda, Carlota Tosat-Bitrian, Jesus Alejandro Bueso de Barrio, Sebastian Thompson, Begona Sot, Gorka Salas, Alvaro Somoza, Ana Espinosa, Milagros Castellanos, Valle Palomo
Summary: The new and unique possibilities offered by nanomaterials have had a significant impact on biomedicine, particularly in disease treatment and diagnosis as well as targeted drug delivery. Technological advancements in the synthesis, characterization, standardization, and therapeutic performance of nanoparticles have enabled the approval of various nanomedicines and novel applications. Research in nanodiagnostics and nanomedicines is actively pursued in Spain, with exponential discoveries in various disease areas. This review provides an overview of the current state of nanotechnology, specifically nanoparticles, for disease treatment in Spain (2017-2022), and offers insights into future trends and directions in nanomedicine research.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Soraya Babaie, Arezou Taghvimi, Joo-Hyun Hong, Hamed Hamishehkar, Seongpil An, Ki Hyun Kim
Summary: Nanotechnology has shown promising applications in pain management, including nanotechnology-based drug delivery, imaging and diagnostic tools, as well as pain measurement. It has provided acceptable results in pain control and has the potential to revolutionize pain management, but further extensive research is needed.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Rachel L. Mynott, Ali Habib, Oliver G. Best, Craig T. Wallington-Gates
Summary: Haematological malignancies are diverse types of cancers affecting the bone marrow, blood, or lymph nodes, and while progress has been made in treatment, many are still incurable. Ferroptosis, a type of cell death that relies on iron and lipid oxidation, shows promise in inducing cancer cell death, especially in cancers resistant to traditional therapies. The main challenges for ferroptosis-inducing therapies are drug delivery and toxicity to healthy tissue, but the use of tumour-targeting and precision medicines, along with nanotechnologies, may help overcome these obstacles. This review discusses the current state of ferroptosis in haematological malignancies and the potential of ferroptosis nanotechnologies in treating diseases like multiple myeloma, lymphoma, and leukemia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Ernest Man, Clare Hoskins
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2020)
Article
Materials Science, Multidisciplinary
Affia Saddique, Zahoor Ahmad, Clare Hoskins, Muhammad Aslam Mirza, Asima Naz, Jamil Ahmad
MATERIALS CHEMISTRY AND PHYSICS
(2020)
Editorial Material
Oncology
Clare Hoskins
Review
Pharmacology & Pharmacy
Miguel Pereira-Silva, Gaurav Chauhan, Matthew D. Shin, Clare Hoskins, Marc J. Madou, Sergio O. Martinez-Chapa, Nicole F. Steinmetz, Francisco Veiga, Ana Claudia Paiva-Santos
Summary: Nano-based approaches, particularly cell membrane-based nanoparticles, have shown promise in enhancing antigen delivery, prolonging drug circulation, and improving drug delivery for COVID-19 treatment by blocking SARS-CoV-2 binding, reducing inflammation, and improving drug delivery.
EXPERT OPINION ON DRUG DELIVERY
(2021)
Article
Pharmacology & Pharmacy
Ali Alsuraifi, Essyrose Mathew, Dimitrios A. Lamprou, Anthony Curtis, Clare Hoskins
Summary: This study successfully synthesized amphiphilic APMA monomers and copolymerized them with HPMA to form a thermoresponsive system for encapsulating and releasing model drugs. HPMAco-(APMA-Dansyl 2%) exhibited the highest drug encapsulation ability, while the incorporation of PEG resulted in faster drug release rates.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biotechnology & Applied Microbiology
Andrei Shishkin, Gaurav Goel, Janis Baronins, Jurijs Ozolins, Clare Hoskins, Saurav Goel
Summary: This paper proposes a new method for cleaning the air using a wet scrubber-reactor, deactivating airborne microbes, particularly SARS-CoV-2, through the Fenton reaction mechanism. The design relies on a high porosity ceramic structure to provide a large contact area, meeting the needs of sustainable development goals.
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2021)
Article
Pharmacology & Pharmacy
Adeolu Oluwasanmi, Clare Hoskins
Summary: The Diels-Alder reaction and its retro breakdown have gained increasing research attention for their advantageous properties such as atomic conservation, reversibility, and substituent retention. It offers a simple coupling reaction for active ingredients with tailorable release in biomedical and nanomedicine applications.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Adeolu Oluwasanmi, Ernest Man, Anthony Curtis, Humphrey H. P. Yiu, Yvonne Perrie, Clare Hoskins
Summary: The study used microfluidics as a new manufacturing process to successfully construct hybrid nanoparticles around 60 nm in size, showing suitability for their production but requiring optimization for configuring a continuous manufacturing plant.
Article
Chemistry, Medicinal
Hamidreza Sahrayi, Elham Hosseini, Sara Karimifard, Nazanin Khayam, Seyed Mohammadmahdi Meybodi, Sahar Amiri, Mahsa Bourbour, Bahareh Farasati Far, Iman Akbarzadeh, Mohammed Bhia, Clare Hoskins, Chaiyavat Chaiyasut
Summary: The study demonstrates that niosome-based nanocarriers can be used as a targeted delivery system for breast cancer therapy. The platform exhibits pH-sensitive drug release properties, with better release in cancerous conditions. Compared to non-targeted formulation and free drugs, the nanocarriers result in improved drug internalization and significant modulation of gene expression related to cell cycle and apoptosis.
Review
Chemistry, Multidisciplinary
Ernest Man, Helen P. Price, Clare Hoskins
Summary: Cutaneous parasites can be treated with drugs or non-drug strategies, but the increasing resistance requires the development of non-drug approaches. Different cutaneous parasites require specific treatment methods. Developing a comprehensive strategy for cutaneous parasites can save time for diagnosis and treatment.
PHARMACEUTICAL RESEARCH
(2022)
Article
Polymer Science
Ernest Man, Adeolu Oluwasanmi, Dimitrios A. Lamprou, Kirsty Goudie, John Liggat, Clare Hoskins
Summary: The study shows that freeze-drying followed by cross-linking of alginate polymer wafers results in a mechanically stronger polymer matrix, maintaining its original structure and thickness.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Polymer Science
Ernest Man, Dimitrios Lamprou, Claire Easdon, Iain McLellan, Humphrey H. P. Yiu, Clare Hoskins
Summary: This study investigates the synergistic effects of using calcium and gallium cations in the cross-linking of alginate. The results show that calcium gallium alginate polymers possess superior properties and have potential applications in the pharmaceutical field.
Article
Pharmacology & Pharmacy
Ernest Man, Claire Easdon, Iain McLellan, Humphrey H. P. Yiu, Clare Hoskins
Summary: Wound care is crucial for effective recovery, but the financial burden it imposes on global national health services necessitates further research. This study develops multifunctional polymer wafers that provide antibacterial activity, high cell viability, and a thermally stable medium for delivering therapeutic agents. The wafers create nanosilver particles within the polymer matrix via a one-pot synthesis method, promoting wound healing. The synthesis of nanosilver particles was compared using different agents, resulting in thermally stable alginate matrices with high swelling capacities and controlled release rates for antibacterial activity.
Article
Pharmacology & Pharmacy
Adeolu Oluwasanmi, Sarah Lindsay, Anthony Curtis, Yvonne Perrie, Clare Hoskins
Summary: Previously reported gold coated iron oxide nanoparticles (Au-IONP's) have shown their efficacy as drug delivery vehicles for gemcitabine conjugated to a thermally labile Diels-Alder linker for pancreatic cancer treatment. The release of gemcitabine was dependent on the length of the linker, with TTLD6 demonstrating the lowest release rate compared to TTLD4 and TTLD3. Drug loading favored linkers with an even number of carbons, possibly due to their perpendicular positioning on the Au-IONP surface.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Editorial Material
Biotechnology & Applied Microbiology
Arza Izzadeen, Lewis Dymock, Clare Hoskins
