Article
Biochemistry & Molecular Biology
Ahmad Agil, Miguel Navarro-Alarcon, Fatma Abo Zakaib Ali, Ashraf Albrakati, Diego Salagre, Cristina Campoy, Ehab Kotb Elmahallawy
Summary: The study revealed that melatonin could improve mitochondrial function in brown fat tissue of obese rats, reducing oxidative stress, promoting ATP production, and decreasing susceptibility to apoptosis.
Article
Multidisciplinary Sciences
Takahiro Seki, Yunlong Yang, Xiaoting Sun, Sharon Lim, Sisi Xie, Ziheng Guo, Wenjing Xiong, Masashi Kuroda, Hiroshi Sakaue, Kayoko Hosaka, Xu Jing, Masahito Yoshihara, Lili Qu, Xin Li, Yuguo Chen, Yihai Cao
Summary: Exposure to cold conditions inhibits the growth of various types of solid tumors by decreasing blood glucose and impeding glycolysis-based metabolism in cancer cells. Cold exposure also reduces glucose uptake in tumor tissue. These findings provide a new concept and paradigm for cancer therapy using a simple and effective approach.
Article
Medicine, Research & Experimental
Jian Yu, Xin Chen, Yuanjin Zhang, Xiangdi Cui, Zhe Zhang, Wenxiu Guo, Dongmei Wang, Shengbo Huang, Yanru Chen, Yepeng Hu, Cheng Zhao, Jin Qiu, Yu Li, Meiyao Meng, Mingwei Guo, Fei Shen, Mengdi Zhang, Ben Zhou, Xuejiang Gu, Jiqiu Wang, Xin Wang, Xinran Ma, Lingyan Xu
Summary: This study demonstrates that azithromycin, a type of macrolide antibiotics, inhibits the functionality of brown and beige adipocytes. Azithromycin accumulates in adipose tissue of obese patients and is associated with BMI and body weight. The antibiotic impairs mitochondrial function in brown and beige adipocytes through inhibiting mitochondrial respiratory complex I and increasing ROS levels.
Article
Biochemistry & Molecular Biology
Peter Aldiss, Jo E. Lewis, Irene Lupini, Ian Bloor, Ramyar Chavoshinejad, David J. Boocock, Amanda K. Miles, Francis J. P. Ebling, Helen Budge, Michael E. Symonds
Summary: This study demonstrates that chronic suppression of adaptive thermogenesis leads to weight gain and increased fat mass in rodents. Living in a cool environment (20 degrees C) and treatment with a β3-adrenoreceptor agonist (YM-178) had minimal effects on metabolic health in obese rats raised at thermoneutrality.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Xiaoxue Yuan, Hongping Lu, Yu Zhang, Ming Han, Kai Han, Pu Liang, Shunai Liu, Jun Cheng
Summary: HCBP6 is an important enhancer that activates brown fat to produce heat. It increases the activity of brown fat by upregulating UCP1 expression and increasing the number of mitochondria. In addition, the loss of HCBP6 leads to metabolic pathway disorder and reduction in brown adipocyte development genes.
JOURNAL OF THERMAL BIOLOGY
(2022)
Article
Veterinary Sciences
Xu-Yang Gao, Bu-Hao Deng, Xin-Rui Li, Yu Wang, Jian-Xin Zhang, Xiao-Yan Hao, Jun-Xing Zhao
Summary: The study found that melatonin enhances the formation of sheep brown adipocytes by activating AMPKα1, reducing lamb mortality and economic losses.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Xin Liu, Wenli Fan, Xujia Zhang, Siyuan Zhan, Tao Zhong, Jiazhong Guo, Yan Wang, Jiaxue Cao, Li Li, Hongping Zhang, Linjie Wang
Summary: This study found that maternal L-carnitine supplementation promotes BAT development and thermogenesis in newborn goats. The lipid composition of BAT was also altered by L-carnitine supplementation.
Article
Multidisciplinary Sciences
Rebecca Oelkrug, Lisbeth Harder, Mehdi Pedaran, Anne Hoffmann, Beke Kolms, Julica Inderhees, Sogol Gachkar, Julia Resch, Kornelia Johann, Olaf Joehren, Kerstin Krause, Jens Mittag
Summary: Maternal hyperthyroidism during pregnancy can program the offspring's glucose sensitivity and response to cold via activation of maternal thyroid hormone receptor beta in a sex-dependent manner.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Xiangdong Liu, Yanting Chen, Liang Zhao, Qiyu Tian, Jeanene Marie deAvila, Mei-Jun Zhu, Min Du
Summary: The study found that maternal succinate supplementation enhances fetal brown adipose tissue development and improves offspring thermogenesis, which helps prevent obesity and metabolic dysfunction caused by a high-fat diet in offspring.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Endocrinology & Metabolism
Zijing Wang, Yunfeng Zhen, Yong Tang, Guangyao Song, Huijuan Ma, Hang Zhao
Summary: Maternal calorie restriction during pregnancy may affect the development and thermogenic capacity of brown adipose tissue in offspring, increasing the risk of adult obesity and metabolic disorders. This may be related to impaired fatty acid oxidation.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Medicine, Research & Experimental
Gai-ling Li, Jie Ping, Hui-jian Chen, Wan-xia Zhang, Jie Fan, Dang-sheng Peng, Li Zhang, You-e Yan
Summary: Maternal nicotine exposure may decrease the brown-like phenotype in BAT of adult male offspring through downregulation of the AMPK-SIRT1-PGC-1α pathway. This impairment of BAT could be a potential mechanism of nicotine-induced obesity in male offspring.
Article
Medicine, Research & Experimental
Camilla P. Dias-Rocha, Mariana M. Almeida, Juliana Woyames, Raphael Mendonca, Cherley B. V. Andrade, Carmen C. Pazos-Moura, Isis H. Trevenzoli
Summary: Maternal HFD led to increased body weight, adiposity, glycemia, leptinemia, and decreased testosterone levels in adult offspring. Contrary to the hypothesis, maternal HFD did not alter cannabinoid receptors in BAT or skeletal muscle, but increased thermogenic markers like uncoupling protein and tyrosine hydroxylase in skeletal muscle of adult offspring, along with changes in mitochondrial morphology.
Article
Biotechnology & Applied Microbiology
Sujoy Ghosh, Chul-Hong Park, Jisu Lee, Nathan Lee, Rui Zhang, Clara Huesing, Dorien Reijnders, Jennifer Sones, Heike Munzberg, Leanne Redman, Ji Suk Chang
Summary: This study demonstrates that maternal cold exposure during pregnancy can influence the gene expression in placental and fetal BAT tissues. The changes in gene expression observed in this study suggest potential effects on fetal brown adipogenesis and placental adaptation to cold stress, warranting further investigation into the implications of these findings.
Article
Evolutionary Biology
Lynn Ayache, Aiden Bushell, Jessica Lee, Iiro Salminen, Bernard Crespi
Summary: This study supports the kinship theory of imprinting and highlights the important role of imprinted genes and associated genomic conflicts in the development and activity of brown adipose tissue (BAT).
EVOLUTION MEDICINE AND PUBLIC HEALTH
(2023)
Article
Biochemistry & Molecular Biology
Maria Angela Guzzardi, Maria Carmen Collado, Daniele Panetta, Maria Tripodi, Patricia Iozzo
Summary: Maternal obesity can result in metabolic dysfunction in offspring, and imaging techniques can be used to assess adipose tissue function. This study found that maternal high-fat diet led to early abnormalities in adipose tissue and later variations in adipose tissue and gut microbiota, providing insight into inter-individual variability in fetal programming and the higher rates of type 2 diabetes in adult women born to obese mothers.
