Mineralocorticoid Receptors in the Pathophysiology of Vascular Inflammation and Atherosclerosis

Novel anti-inflammatory therapies for the treatment of atherosclerosis

(2015) Razi Khan et al.   ATHEROSCLEROSIS

Aldosterone up-regulates MMP-9 and MMP-9/NGAL expression in human neutrophils through p38, ERK1/2 and PI3K pathways

(2015) Alexandre Gilet et al.   EXPERIMENTAL CELL RESEARCH

Endothelial Mineralocorticoid Receptors Differentially Contribute to Coronary and Mesenteric Vascular Function Without Modulating Blood PressureNovelty and Significance

(2015) Katelee Barrett Mueller et al.   HYPERTENSION

Eplerenone in chronic heart failure with depressed systolic function

(2015) Maurizio Volterrani et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Mineralocorticoid exposure and receptor activity modulate microvascular endothelial function in African Americans with and without hypertension

(2015) Appesh Mohandas et al.   VASCULAR MEDICINE

Mineralocorticoid Receptor Blockade Improves Coronary Microvascular Function in Individuals With Type 2 Diabetes

(2014) Rajesh Garg et al.   DIABETES

Estrogen Receptor Inhibits Mineralocorticoid Receptor Transcriptional Regulatory Function

(2014) Katelee Barrett Mueller et al.   ENDOCRINOLOGY

Mineralocorticoid receptor signaling reduces numbers of circulating human naïve T cells and increases their CD62L, CCR7, and CXCR4 expression

(2014) Luciana Besedovsky et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Temporary mineralocorticoid receptor antagonism during the development of hypertension improves cerebral artery dilation

(2014) Jonathon L McClain et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Endothelial mineralocorticoid receptor activation enhances endothelial protein C receptor and decreases vascular thrombosis in mice

(2014) Jérémy Lagrange et al.   FASEB JOURNAL

Endothelial Cell Mineralocorticoid Receptors Regulate Deoxycorticosterone/Salt-Mediated Cardiac Remodeling and Vascular Reactivity But Not Blood Pressure

(2014) Amanda J. Rickard et al.   HYPERTENSION

Spironolactone Decreases DOCA–Salt–Induced Organ Damage by Blocking the Activation of T Helper 17 and the Downregulation of Regulatory T Lymphocytes

(2014) Cristián A. Amador et al.   HYPERTENSION

Eplerenone reduces arterial thrombosis in diabetic rats

(2014) Agnieszka Zakrzeska et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

The aldosterone receptor antagonist spironolactone prevents peritoneal inflammation and fibrosis

(2014) Lei Zhang et al.   LABORATORY INVESTIGATION

Spironolactone improves endothelial dysfunction in streptozotocin-induced diabetic rats

(2014) Heba Adel et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Mineralocorticoid receptor signaling: Crosstalk with membrane receptors and other modulators

(2014) S. Meinel et al.   STEROIDS

Mineralocorticoid receptors in immune cells: Emerging role in cardiovascular disease

(2014) Nicholas C. Bene et al.   STEROIDS

Endothelial mineralocorticoid receptor activation mediates endothelial dysfunction in diet-induced obesity

(2013) Nicola Schäfer et al.   EUROPEAN HEART JOURNAL

Aldosterone levels and inflammatory stimulation in essential hypertensive patients

(2013) V Tzamou et al.   JOURNAL OF HUMAN HYPERTENSION

Role of Rac1–mineralocorticoid-receptor signalling in renal and cardiac disease

(2013) Miki Nagase et al.   Nature Reviews Nephrology

Spironolactone Attenuates Bleomycin-Induced Pulmonary Injury Partially via Modulating Mononuclear Phagocyte Phenotype Switching in Circulating and Alveolar Compartments

(2013) Wen-Jie Ji et al.   PLoS One

Aldosterone Increases Early Atherosclerosis and Promotes Plaque Inflammation Through a Placental Growth Factor‐Dependent Mechanism

(2013) Adam P. McGraw et al.   Journal of the American Heart Association

The mineralocorticoid receptor-p38MAPK-NFκB or ERK-Sp1 signal pathways mediate aldosterone-stimulated inflammatory and profibrotic responses in rat vascular smooth muscle cells

(2012) Chuan-jiang Zhu et al.   ACTA PHARMACOLOGICA SINICA

Effects of Aldosterone on Human Atherosclerosis: Plasma Aldosterone and Progression of Carotid Plaque

(2012) Omar de Rita et al.   CANADIAN JOURNAL OF CARDIOLOGY

Activation of the Renin-Angiotensin System Mediates the Effects of Dietary Salt Intake on Atherogenesis in the Apolipoprotein E Knockout Mouse

(2012) Chris Tikellis et al.   HYPERTENSION

Aldosterone Modulates Endothelial Permeability and Endothelial Nitric Oxide Synthase Activity by Rearrangement of the Actin Cytoskeleton

(2012) Torsten Kirsch et al.   HYPERTENSION

Eplerenone Reduced Lesion Size in Early but Not Advanced Atherosclerosis in Apolipoprotein E–Deficient Mice

(2012) Ayelet Raz-Pasteur et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Mineralocorticoid receptor blockade inhibits accelerated atherosclerosis induced by a low sodium diet in apolipoprotein E-deficient mice

(2012) Ayelet Raz-Pasteur et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

Serum Aldosterone Is Associated with Inflammation and Aortic Stiffness in Normotensive Overweight and Obese Young Adults

(2011) Jennifer N. Cooper et al.   CLINICAL AND EXPERIMENTAL HYPERTENSION

Aldosterone stimulates nuclear factor-kappa B activity and transcription of intercellular adhesion molecule-1 and connective tissue growth factor in rat mesangial cells via serum- and glucocorticoid-inducible protein kinase-1

(2011) Yoshio Terada et al.   Clinical and Experimental Nephrology

Aldosterone, mortality, and acute ischaemic events in coronary artery disease patients outside the setting of acute myocardial infarction or heart failure

(2011) Fabrice Ivanes et al.   EUROPEAN HEART JOURNAL

Study of the mechanisms of aldosterone prothrombotic effect in rats

(2011) Anna Gromotowicz et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

Mineralocorticoid receptors in vascular function and disease

(2011) Amy McCurley et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

11β-Hydroxysteroid Dehydrogenase Type 2 Deficiency Accelerates Atherogenesis and Causes Proinflammatory Changes in the Endothelium inApoe−/−Mice

(2010) Graeme A. Deuchar et al.   ENDOCRINOLOGY

Myeloid mineralocorticoid receptor controls macrophage polarization and cardiovascular hypertrophy and remodeling in mice

(2010) Michael G. Usher et al.   JOURNAL OF CLINICAL INVESTIGATION

Nitric Oxide-mediated Dilation of Arterioles to Intraluminal Administration of Aldosterone

(2009) Erwan Heylen et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Aldosterone Promotes Autoimmune Damage by Enhancing Th17-Mediated Immunity

(2009) Andrés A. Herrada et al.   JOURNAL OF IMMUNOLOGY

The Nuclear Factor NF- B Pathway in Inflammation

(2009) T. Lawrence   Cold Spring Harbor Perspectives in Biology

Aldosterone modifies hemostasis via upregulation of the protein-C receptor in human vascular endothelium

(2008) Elodie Ducros et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Functional Mineralocorticoid Receptors in Human Vascular Endothelial Cells Regulate Intercellular Adhesion Molecule-1 Expression and Promote Leukocyte Adhesion

(2008) Massimiliano Caprio et al.   CIRCULATION RESEARCH

Aldosterone and Vascular Inflammation

(2008) Nancy J. Brown   HYPERTENSION

Aldosterone Activates NF- B in the Collecting Duct

(2008) V. Leroy et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY