Article
Psychology, Clinical
Xiaolong Peng, Xiaoping Wu, Ruxue Gong, Rui Yang, Xiang Wang, Wenzhen Zhu, Pan Lin
Summary: The study identified significant changes in functional connectivity (FC) of different anterior cingulate cortex (ACC) sub-regions in major depressive disorder (MDD) patients, associated with distinct symptoms of depression. The findings provide new insights into the role of ACC sub-regions and the default network (DN) in the pathophysiology of MDD.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Jungho Cha, Ki Sueng Choi, Justin K. Rajendra, Callie L. McGrath, Patricio Riva-Posse, Paul E. Holtzheimer, Martijn Figee, Brian H. Kopell, Helen S. Mayberg
Summary: Experimental studies on subcallosal cingulate deep brain stimulation (SCC DBS) for treatment-resistant depression (TRD) have shown that the behavioral effects of the stimulation have a different timeline, with rapid changes after initial stimulation and both early and delayed changes during ongoing chronic stimulation. This study investigated the longitudinal changes in resting-state regional cerebral blood flow (rCBF) and glucose metabolism in TRD patients receiving SCC DBS over a period of 6 months. The results revealed significant effects of SCC DBS on the salience network (SN) and default mode network (DMN), with changes in rCBF and glucose metabolism observed after surgery and diverging response patterns between responders and non-responders.
MOLECULAR PSYCHIATRY
(2023)
Article
Psychology, Clinical
Ji-Yoon Lee, Chi-Hyun Choi, Minkyung Park, Sunyoung Park, Jung-Seok Choi
Summary: The study compared EEG source functional connectivity between patients with IGD and healthy controls, finding hyper-connectivities within the DMN and RSN in IGD patients. Additionally, a negative correlation was observed between the severity of IGD symptoms and gaming time with EEG source connectivity.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Psychiatry
Andrew R. Gerlach, Helmet T. Karim, Joseph Kazan, Howard J. Aizenstein, Robert T. Krafty, Carmen Andreescu
Summary: Severe worry in older adults is associated with complex and distinct neurobiological features, including dominant contributions from intra-connectivities of the default mode network, and regions like the anterior cingulate, temporal lobe, and thalamus showing overwhelmingly negative association with worry. Recognizing the most salient connections may be beneficial for targeted interventions aimed at reducing disease morbidity associated with severe worry in older adults.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Clinical Neurology
Norma Verdolini, Marta Moreno-Ortega, Pilar Salgado-Pineda, Gemma Monte, Ana Martinez de Aragon, Monica Dompablo, Peter J. McKenna, Raymond Salvador, Tomas Palomo, Edith Pomarol-Clotet, Roberto Rodriguez-Jimenez
Summary: This study examined the brain activity of bipolar disorder patients during the Stroop task and found that there were no differences in activation between the patients and healthy subjects. However, the patients showed significant failure of de-activation in specific brain regions. These findings suggest that the regulatory component of cognitive control remains intact in bipolar disorder, but there may be dysfunction in the default mode network.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Biology
Xinrui Wang, Zhao Chang, Rong Wang
Summary: The nested spectral partition (NSP) method, along with fMRI data, machine learning, and gene ontology analysis, reveals that positive and negative symptoms of schizophrenia have opposite effects on the functional organization of resting-state brains. This research sheds light on the neural basis of schizophrenia and could contribute to more accurate diagnostic criteria for the disease.
COMMUNICATIONS BIOLOGY
(2023)
Review
Behavioral Sciences
Laith Alexander, Luke A. Jelen, Mitul A. Mehta, Allan H. Young
Summary: The subdivisions of the anterior cingulate cortex (ACC) play a crucial role in the etiology and treatment of major depression, particularly in relation to the antidepressant effects of ketamine. The synergistic relationship between neuroimaging studies in humans and brain manipulations in animals helps understand the causal relationship between changes in brain activity and therapeutic efficacy.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Clinical Neurology
Yang Yang, Qian Cui, Fengmei Lu, Yajing Pang, Yuyan Chen, Qin Tang, Di Li, Ting Lei, Zongling He, Shan Hu, Jiaxin Deng, Huafu Chen
Summary: The study revealed abnormal functional connectivity patterns of DMN subsystems in patients with bipolar disorder during major depressive episodes, and these abnormalities were associated with high levels of pessimism, highlighting the importance of pathological mechanisms in this disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Boadie W. Dunlop, Jungho Cha, Ki Sueng Choi, Justin K. Rajendra, Charles B. Nemeroff, W. Edward Craighead, Helen S. Mayberg
Summary: This study aimed to determine the shared and unique changes in brain resting-state functional connectivity (rsFC) between patients with major depressive disorder who achieved remission with cognitive-behavioral therapy (CBT) or with antidepressant medication. The results showed that remission from major depression via treatment with CBT or medication is associated with changes in rsFC that are mostly specific to the treatment modality, providing biological support for the clinical practice of switching between or combining these treatment approaches.
AMERICAN JOURNAL OF PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Martin Pastrnak, Eva Simkova, Tomas Novak
Summary: The symptomatic overlap between bipolar disorder (BD) and major depressive disorder (MDD) presents a major diagnostic and therapeutic challenge. However, increased activity in the insula region may serve as a potential biomarker for differentiating between the two disorders.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Xiao-Min Xu, Jian Wang, Richard Salvi, Li-Jie Liu, Yu-Chen Chen, Gao-Jun Teng
Summary: The study aimed to investigate the effects of noise-induced cochlear hearing loss on the central nervous system during the early stage and identify the neural substrate for aberrant patterns mediating noise-related anxiety/depression. Rats were exposed to broad band noise to induce hearing loss. Behavioral tests and resting-state fMRI were conducted to evaluate emotional conditions and aberrant neural activity. Functional connectivity analysis revealed widespread reductions in functional connectivity in rats with noise exposure compared to control groups, suggesting an acoustic-causing network for anxiety and depression related to noise exposure.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Liangyu Gong, Hui Zhou, Conghui Su, Fengji Geng, Wan Xi, Binyu Teng, Kai Yuan, Min Zhao, Yuzheng Hu
Summary: The study found that self-control is negatively correlated with Internet gaming disorder symptoms, and self-control partially influences these symptoms through brain connectivity. Additionally, analysis of the reward-anticipation limbic pathway revealed its contribution to Internet gaming disorder symptoms, independent of self-control.
Article
Clinical Neurology
Yupeng Guo, Guangyuan Zou, Yan Shao, Jie Chen, Yuezhen Li, Jiayi Liu, Ping Yao, Shuqin Zhou, Jing Xu, Sifan Hu, Jia-Hong Gao, Qihong Zou, Hongqiang Sun
Summary: This study aims to investigate the relationship between sleep transition dynamics and stage-specific functional connectivity (FC) of the anterior cingulate cortex (ACC) in patients with insomnia disorder (ID). The results show that patients with ID have a higher likelihood of transitioning from N2 to wakefulness compared to healthy controls, and there is a group-by-stage interaction of connectivity between ACC and cerebellar, subcortical, and cortical regions. Additionally, there is a significant positive correlation between the transition probability from N2 to wakefulness and the FC of ACC with the anterior cerebellum in patients with ID. These findings contribute to understanding the relationship between sleep disruption and ACC function, highlighting the potential therapeutic target of N2 sleep in reducing sleep disruption.
Review
Biochemistry & Molecular Biology
Matteo Martino, Paola Magioncalda
Summary: The study presents a three-dimensional model on the relationship between intrinsic brain functioning and behavioral patterns in bipolar disorder. This model includes external, internal, and associative units, each connected with the environment and playing a role in processing different inputs and outputs. The neurotransmitter signaling within each unit modulates network activity levels, ultimately influencing the expression of psychomotor, affective, and thought dimensions in BD.
MOLECULAR PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Anna Todeva-Radneva, Sevdalina Kandilarova, Rositsa Paunova, Drozdstoy Stoyanov, Tina Zdravkova, Ronald Sladky
Summary: This study aimed to explore possible differences in whole-brain functional connectivity in patients with major depressive disorder (MDD), bipolar disorder (BD), and healthy controls (HC). The results showed increased connectivity in certain brain regions in the BD group compared to the HC group, while the MDD group showed enhanced connectivity in different regions. These findings suggest that these connectivity patterns may serve as potential diagnostic biomarkers for MDD and BD.
Review
Psychology, Clinical
San Lee, Keum Hwa Lee, Kyung Mee Park, Sung Jong Park, Won Jae Kim, Jinhee Lee, Andreas Kronbichler, Lee Smith, Marco Solmi, Brendon Stubbs, Ai Koyanagi, Louis Jacob, Andrew Stickley, Trevor Thompson, Elena Dragioti, Hans Oh, Andre R. Brunoni, Andre F. Carvalho, Joaquim Radua, Suk Kyoon An, Kee Namkoong, Eun Lee, Jae Il Shin, Paolo Fusar-Poli
Summary: Errors in data extraction may account for discrepancies in previous meta-analyses on the association between depression and inflammatory biomarkers.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Behavioral Sciences
Jaeun Ahn, DeokJong Lee, Young-Chul Jung, Kyung Ran Kim
Summary: This preliminary study examined the structural and functional neural changes of cancer-associated cognitive decline (CACD) in gastric cancer patients undergoing chemotherapy. Results showed a significant decline in attention and executive function in patients receiving chemotherapy compared to those not receiving chemotherapy. Resting-state functional magnetic resonance imaging analysis revealed a significant group-by-time interaction in a specific brain region, suggesting neuropathological processes similar to age-related neurodegenerative disorders in CACD patients.
BRAIN AND BEHAVIOR
(2022)
Article
Public, Environmental & Occupational Health
Youngrong Lee, Ye Jin Jeon, Sunghyuk Kang, Jae Il Shin, Young-Chul Jung, Sun Jae Jung
Summary: The study aimed to summarize the association between the time spent on social media platforms during the COVID-19 quarantine and mental health outcomes, specifically anxiety and depression. The analysis demonstrated that excessive time spent on social media platforms was significantly associated with higher likelihood of experiencing symptoms of anxiety and depression.
Article
Psychiatry
Deokjong Lee, Jung Eun Lee, Junghan Lee, Changsoo Kim, Young-Chul Jung
Summary: This study found that firefighters with PTSD had longer reaction times when faced with trauma-related interferences. They showed excessive brain activation in the left insula and weaker functional connectivity with executive control-related brain regions. These aberrant brain activation and functional connectivity may be related to the development and maintenance of PTSD symptoms in firefighters.
Article
Psychiatry
Deokjong Lee, Woojin Kim, Jung Eun Lee, Junghan Lee, Yun Tae Kim, Seung Koo Lee, Sung Soo Oh, Ki Soo Park, Sang Baek Koh, Changsoo Kim, Young-Chul Jung
Summary: Firefighters are at risk for occupational stress and burnout, which can impact brain functional connectivity. This study investigated the relationship between occupational stress and brain FC in firefighters. The results showed negative correlations between occupational stress and FC within the central executive network and the default mode network, but a positive correlation between occupational stress and FC between the salience network and the default mode network. Proper management of occupational stress may prevent clinical problems caused by changes in brain functional networks.
PSYCHIATRY RESEARCH
(2022)
Article
Neurosciences
Minjung Kim, Deokjong Lee, Woojin Kim, Jung Eun Lee, Junghan Lee, Yun Tae Kim, Seung-Koo Lee, Sung Soo Oh, Ki Soo Park, Sang Baek Koh, Changsoo Kim, Young-Chul Jung
NEUROSCIENCE LETTERS
(2022)
Article
Psychiatry
Manjae Kwon, Young-Chul Jung, Deokjong Lee, Junghan Lee
Summary: This study investigated functional connectivity in problematic smartphone users and found alterations in connectivity between the default mode network (DMN) and attentional networks, which correlated with the severity of problematic smartphone use. Increased bottom-up and interoceptive attentional processing might play an important role in problematic smartphone use.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Clinical Neurology
Jae Won Oh, Sun Mi Kim, Deokjong Lee, Dong Keon Yon, Seung Won Lee, Lee Smith, Karel Kostev, Ai Koyanagi, Marco Solmi, Andre F. Carvalho, Jae Il Shin, Nak-Hoon Son, San Lee
Summary: This study utilized datasets from Brazil, China, Europe, Korea, the UK, and the US to investigate the association between handgrip strength and depression in middle and older aged adults. The results showed that lower handgrip strength was associated with an increased likelihood of depression. Early assessment of handgrip strength may help identify individuals at risk for depression among this population.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Multidisciplinary Sciences
Jaeun Ahn, DeokJong Lee, Jung Eun Lee, Young-Chul Jung
Summary: This study aimed to explore the shared and unique functional neurobiological basis of binge eating disorder (BED) and bulimia nervosa (BN). The results showed differences in brain activation patterns in reward sensitivity between these disorders. BED patients exhibited higher impulsivity compared to healthy controls, and both BED and BN patients showed weaker functional connectivity (FC) between the left lateral orbitofrontal cortex (OFC) and the right precuneus. Additionally, in BED patients, the FC strength between these regions was negatively correlated with self-reported impulsivity. In both BED and BN, FC between the left lateral OFC and the right dorsolateral prefrontal cortex was weaker than in controls, while FC between the left medial OFC and the right cerebellar lobule IV was stronger in BED than in other groups.
Article
Psychiatry
Deokjong Lee, Jin Young Park, Woo Jung Kim
Summary: Subjective cognitive decline (SCD) is a clinical condition characterized by self-experienced cognitive decline, without impairment on standardized cognitive tests like mild cognitive impairment (MCI). This study investigated the functional connectivity (FC) characteristics in SCD subjects compared to healthy controls and MCI patients. Resting-state functional MRI was used to analyze the FC patterns, focusing on the default mode network (DMN) and dorsal attention network (DAN) regions. The results showed that the SCD group exhibited stronger FC between DMN seeds and the supramarginal gyrus compared to the MCI group. Both the SCD and MCI groups showed stronger FC between the left lateral parietal cortex and right dorsolateral prefrontal cortex. Moreover, weaker FC of the right posterior intraparietal sulcus in the left anterior cingulate cortex and left insula was observed in both the SCD and MCI groups. Hyperconnectivity between the right lateral parietal cortex and left supramarginal gyrus was associated with better performance on the Controlled Oral Word Association Test in the SCD group. In conclusion, SCD is characterized by specific FC alterations related to DMN and DAN, with distinct hyperconnectivity between DMN seeds and the supramarginal gyrus. These findings suggest that SCD has distinct patterns of FC compared to MCI, particularly in relation to verbal fluency retention.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Psychiatry
Jae Won Oh, Sun Mi Kim, Deokjong Lee, Nak-Hoon Son, Jinsun Uh, Ju Hong Yoon, Yukyung Choi, San Lee
Summary: This study validated the use of the PHQ-2 and ISI-2 for daily screening and found that the modified versions were strong candidates for daily screening of depression and insomnia, respectively.
JMIR MENTAL HEALTH
(2023)
Article
Psychology, Clinical
Suonaa Lee, Jung Tak Park, Minji Bang, Suk Kyoon An, Kee Namkoong, Hye Yoon Park, Eun Lee
Summary: This study evaluated the relationship between theory of mind (ToM) and hair cortisol concentration (HCC) and found that childhood trauma moderates this relationship. This indicates the importance of childhood trauma in social cognition and stress response.
EUROPEAN JOURNAL OF PSYCHOTRAUMATOLOGY
(2022)