Article
Neurosciences
Sonja M. C. de Zwarte, Rachel M. Brouwer, Ingrid Agartz, Martin Alda, Silvia Alonso-Lana, Carrie E. Bearden, Alessandro Bertolino, Aurora Bonvino, Elvira Bramon, Elizabeth E. L. Buimer, Wiepke Cahn, Erick J. Canales-Rodriguez, Dara M. Cannon, Tyrone D. Cannon, Xavier Caseras, Josefina Castro-Fornieles, Qiang Chen, Yoonho Chung, Elena de la Serna, Caterina del Mar Bonnin, Caroline Demro, Annabella Di Giorgio, Gaelle E. Doucet, Mehmet Cagdas Eker, Susanne Erk, Mar Fatjo-Vilas, Scott C. Fears, Sonya F. Foley, Sophia Frangou, Janice M. Fullerton, David C. Glahn, Vina M. Goghari, Jose M. Goikolea, Aaron L. Goldman, Ali Saffet Gonul, Oliver Gruber, Tomas Hajek, Emma L. Hawkins, Andreas Heinz, Ceren Hidiroglu Ongun, Manon H. J. Hillegers, Josselin Houenou, Hilleke E. Hulshoff Pol, Christina M. Hultman, Martin Ingvar, Viktoria Johansson, Erik G. Jonsson, Fergus Kane, Matthew J. Kempton, Marinka M. G. Koenis, Miloslav Kopecek, Bernd Kraemer, Stephen M. Lawrie, Rhoshel K. Lenroot, Machteld Marcelis, Venkata S. Mattay, Colm McDonald, Andreas Meyer-Lindenberg, Stijn Michielse, Philip B. Mitchell, Dolores Moreno, Robin M. Murray, Benson Mwangi, Leila Nabulsi, Jason Newport, Cheryl A. Olman, Jim van Os, Bronwyn J. Overs, Aysegul Ozerdem, Giulio Pergola, Marco M. Picchioni, Camille Piguet, Edith Pomarol-Clotet, Joaquim Radua, Ian S. Ramsay, Anja Richter, Gloria Roberts, Raymond Salvador, Aybala Saricicek Aydogan, Salvador Sarro, Peter R. Schofield, Esma M. Simsek, Fatma Simsek, Jair C. Soares, Scott R. Sponheim, Gisela Sugranyes, Timothea Toulopoulou, Giulia Tronchin, Eduard Vieta, Henrik Walter, Daniel R. Weinberger, Heather C. Whalley, Mon-Ju Wu, Nefize Yalin, Ole A. Andreassen, Christopher R. K. Ching, Sophia I. Thomopoulos, Theo G. M. van Erp, Neda Jahanshad, Paul M. Thompson, Rene S. Kahn, Neeltje E. M. van Haren
Summary: First-degree relatives of patients diagnosed with schizophrenia show widespread thinner cortex, while relatives of patients diagnosed with bipolar disorder show widespread larger cortical surface area. Both groups have lower IQ scores compared to controls, with schizophrenia relatives showing more pronounced brain abnormalities and bipolar disorder relatives showing weaker effects after adjusting for IQ or educational attainment.
HUMAN BRAIN MAPPING
(2022)
Article
Psychiatry
Petra E. Rupert, Michael Pogue-Geile
Summary: This meta-analysis compared the functional brain similarities and differences between individuals at familial risk for schizophrenia (FRSZ) or bipolar disorder (FRBD). The results showed that FRSZ individuals had lower activation in the left precuneus and left middle frontal gyrus compared to controls. FRBD individuals had lower activation in the left superior parietal gyrus and right angular gyrus, and higher activation in the left superior frontal gyrus compared to controls. No significant differences were found between FRSZ and FRBD.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Psychiatry
Rositsa Paunova, Cristina Ramponi, Sevdalina Kandilarova, Anna Todeva-Radneva, Adeliya Latypova, Drozdstoy Stoyanov, Ferath Kherif
Summary: In this study, multivariate methods were used to identify key brain regions involved in shaping connectivity patterns of networks associated with major psychiatric disorders. The results suggest that the multivariate structural covariance method can be used to identify specific regions with higher predictive value for specific psychiatric diagnoses.
FRONTIERS IN PSYCHIATRY
(2023)
Review
Clinical Neurology
Licia P. Luna, Joaquim Radua, Lydia Fortea, Gisela Sugranyes, Adriana Fortea, Paolo Fusar-Poli, Lee Smith, Joseph Firth, Jae Il Shin, Andre R. Brunoni, Muhammad I. Husain, Muhammad O. Husian, Haris I. Sair, Walber O. Mendes, Luiz Ricardo A. Uchoa, Michael Berk, Michael Maes, Zafiris J. Daskalakis, Sophia Frangou, Michele Fornaro, Eduard Vieta, Brendon Stubbs, Marco Solmi, Andre F. Carvalho
Summary: Neuroimaging studies on individuals at genetic or clinical high risk for psychosis or bipolar disorder have uncertain findings. A meta-analytic review of whole-brain voxel-based morphometry and functional magnetic resonance imaging studies identified several results, including lower gray matter volumes in certain brain regions for genetic or clinical high-risk subjects, as well as reductions in gray matter and hypoactivation in specific brain areas for individuals at clinical high risk. Further neuroimaging studies are needed to investigate individuals with genetic or clinical high-risk bipolar disorder.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Psychiatry
Claudia Barth, Stener Nerland, Ann-Marie G. de Lange, Laura A. Wortinger, Eva Hilland, Ole A. Andreassen, Kjetil N. Jorgensen, Ingrid Agartz
Summary: Abnormalities in amygdala volume are frequently seen in schizophrenia and bipolar disorders. Patients with schizophrenia tend to have smaller amygdala volumes compared to healthy controls, particularly in certain nuclei like the basal nucleus.
SCHIZOPHRENIA BULLETIN
(2021)
Article
Clinical Neurology
James A. Karantonis, Susan L. Rossell, Sean P. Carruthers, Philip Sumner, Matthew Hughes, Melissa J. Green, Christos Pantelis, Katherine E. Burdick, Vanessa Cropley, Tamsyn E. Van Rheenen
Summary: The study found that cross-diagnostic cognitive subgroups of individuals with SSD and BD did not appear to be clearly distinguished by patterns in brain morphology, with only some differences evident in specific brain regions.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Margaret A. Niznikiewicz
Summary: The Commentary discusses research on language and communication dysfunction in schizophrenia. The author has used behavioral and imaging methodologies to investigate this disorder. The article briefly outlines the path towards a comprehensive understanding of the underlying causes and explores possible therapeutic approaches.
PSYCHIATRY RESEARCH
(2023)
Article
Clinical Neurology
Lisa Rauer, Sarah Trost, Aleksandra Petrovic, Oliver Gruber
Summary: Patients with bipolar disorder and schizophrenia exhibit distinct neural activation patterns in certain brain regions, with bipolar patients demonstrating specific hyperactivation in frontal and parietal areas compared to schizophrenia patients and healthy controls. Moreover, during more demanding cognitive tasks, both patient groups show hypoactivations in certain frontal areas and the ventral pathway.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2021)
Article
Psychology, Multidisciplinary
Mirona Letitia Dobri, Alexandre Paim Diaz, Sudhakar Selvaraj, Joao Quevedo, Consuelo Walss-Bass, Jair C. Soares, Marsal Sanches
Summary: Schizophrenia and bipolar disorder share many similarities in terms of their premorbid course, clinical profile, genetic factors and treatment approaches. Neuroimaging studies show that they both involve structural changes and functional dysconnectivity in critical brain regions, suggesting a continuum between these two disorders.
BEHAVIORAL SCIENCES
(2022)
Article
Psychology, Clinical
Shinsuke Koike, Eisuke Sakakibara, Yoshihiro Satomura, Hanako Sakurada, Mika Yamagishi, Jun Matsuoka, Naohiro Okada, Kiyoto Kasai
Summary: This study reveals a robust relationship between prefrontal function and behavioral outcomes across three major psychiatric disorders through a large-sample neuroimaging study.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Clinical Neurology
Jeremy D. Levit, Jacquelyn L. Meyers, Penelope Georgakopoulos, Michele T. Pato
Summary: This study found that alcohol use disorder is common among individuals with bipolar disorder and schizophrenia. The association between severe mental illness and alcohol use problems is strongest in females, particularly those from racial minority groups, smokers, and those with psychotic disorders.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Takuya Ishida, Yuko Nakamura, Saori C. Tanaka, Yuki Mitsuyama, Satoshi Yokoyama, Hotaka Shinzato, Eri Itai, Go Okada, Yuko Kobayashi, Takahiko Kawashima, Jun Miyata, Yujiro Yoshihara, Hidehiko Takahashi, Susumu Morita, Shintaro Kawakami, Osamu Abe, Naohiro Okada, Akira Kunimatsu, Ayumu Yamashita, Okito Yamashita, Hiroshi Imamizu, Jun Morimoto, Yasumasa Okamoto, Toshiya Murai, Kiyoto Kasai, Mitsuo Kawato, Shinsuke Koike
Summary: This paper investigated the dynamic aspects of aberrant causal connections among large-scale networks in multiple psychiatric disorders using dynamic causal modeling. The results showed that the decreased self-inhibitory connection of the Limbic network was a common aberrant pattern across psychiatric disorders. Additionally, disorder-specific patterns were found for schizophrenia, major depressive disorder, and bipolar disorder. The study suggests that aberrant dynamics among large-scale networks could serve as key biomarkers for transdiagnostic psychiatric disorders.
SCHIZOPHRENIA BULLETIN
(2023)
Review
Psychiatry
Riccardo Bortoletto, Fabiana Piscitelli, Anna Candolo, Sagnik Bhattacharyya, Matteo Balestrieri, Marco Colizzi
Summary: This systematic review examines the biobehavioral role of palmitoylethanolamide (PEA) in psychosis. The findings suggest that PEA may serve as a potential biomarker for psychosis and supplementation of PEA could be beneficial for the treatment of the disorder.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Clinical Neurology
Niccolo Zovetti, Maria Gloria Rossetti, Cinzia Perlini, Paolo Brambilla, Marcella Bellani
Summary: This study found neuroimaging evidence suggesting a link between bipolar disorder (BD) and neurodegenerative processes. It showed a progressive reduction in gray matter volume throughout the whole brain, as well as changes in deep brain structures and prefrontal regions. BD patients also exhibited larger gaps between predicted and chronological brain age compared to normal aging. Further systematic reviews and meta-analyses are needed to quantify the impact of brain aging-related effects in BD.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Sharmin Ghaznavi, Tina Chou, Darin D. Dougherty, Andrew A. Nierenberg
Summary: Different patterns of neural connectivity exist for negative and positive rumination in patients with bipolar disorder (BD). Patients with BD show stronger functional connectivity between the posterior cingulate cortex (PCC) and medial prefrontal cortex (MPFC) during rest and positive rumination compared to healthy controls (HC). Furthermore, following positive rumination, the PCC and MPFC exhibit higher levels of activity during the processing of positive self-relevant traits. Patients with BD also demonstrate stronger functional connectivity between the PCC and inferior parietal lobule during rest and negative rumination compared to HC.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
