Sarcopenia and Androgens: A Link between Pathology and Treatment

Muscle-specific inositide phosphatase (MIP/MTMR14) is reduced with age and its loss accelerates skeletal muscle aging process by altering calcium homeostasis

(2016) Sandra Romero-Suarez et al.   Aging-US

Testosterone in men with advanced liver disease: Abnormalities and implications

(2015) Marie Sinclair et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Testosterone is essential for skeletal muscle growth in aged mice in a heterochronic parabiosis model

(2014) Indranil Sinha et al.   CELL AND TISSUE RESEARCH

Biological Markers in Older People at Risk of Mobility Limitations

(2014) Giuseppe Lippi et al.   CURRENT PHARMACEUTICAL DESIGN

Sarcopenia, and its association with cardiometabolic and functional characteristics in Taiwan: Results from I-Lan Longitudinal Aging Study

(2014) Li-Kuo Liu et al.   Geriatrics & Gerontology International

Low free testosterone is associated with loss of appendicular muscle mass in Japanese community-dwelling women

(2014) Atsumu Yuki et al.   Geriatrics & Gerontology International

Testosterone, Sex Hormone-Binding Globulin and the Metabolic Syndrome in Men: An Individual Participant Data Meta-Analysis of Observational Studies

(2014) Judith S. Brand et al.   PLoS One

Regulation of Satellite Cell Function in Sarcopenia

(2014) Stephen E. Alway et al.   Frontiers in Aging Neuroscience

Off-label use of hormones as an antiaging strategy: a review

(2014) Nikolaos Samaras et al.   Clinical Interventions in Aging

Age-dependent alteration in muscle regeneration: the critical role of tissue niche

(2013) Laura Barberi et al.   BIOGERONTOLOGY

Signalling pathways regulating muscle mass in ageing skeletal muscle. The role of the IGF1-Akt-mTOR-FoxO pathway

(2013) M. Sandri et al.   BIOGERONTOLOGY

Testosterone increases GLUT4-dependent glucose uptake in cardiomyocytes

(2013) Carlos Wilson et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A phase IIA randomized, placebo-controlled clinical trial to study the efficacy and safety of the selective androgen receptor modulator (SARM), MK-0773 in female participants with sarcopenia

(2013) Dimitris A. Papanicolaou et al.   Journal of Nutrition Health & Aging

Testosterone Signals through mTOR and Androgen Receptor to Induce Muscle Hypertrophy

(2013) CARLA BASUALTO-ALARCÓN et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Low appendicular skeletal muscle mass (ASM) with limited mobility and poor health outcomes in middle-aged African Americans

(2013) Theodore K. Malmstrom et al.   Journal of Cachexia Sarcopenia and Muscle

Low testosterone levels induce apoptosis via active 3-caspase dependent signaling in the bladder wall of male rats

(2012) Fábio Lorenzetti et al.   Aging Male

Lost in translation: regulation of skeletal muscle protein synthesis

(2012) Lukas G Weigl   CURRENT OPINION IN PHARMACOLOGY

Mass spectrometry-based proteomic analysis of middle-aged vs. aged vastus lateralis reveals increased levels of carbonic anhydrase isoform 3 in senescent human skeletal muscle

(2012) LISA STAUNTON et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Testosterone exerts antiapoptotic effects against H2O2 in C2C12 skeletal muscle cells through the apoptotic intrinsic pathway

(2012) Lucía Pronsato et al.   JOURNAL OF ENDOCRINOLOGY

Factors contributing to the variability in muscle ageing

(2012) Hans Degens et al.   MATURITAS

Testosterone regulation of Akt/mTORC1/FoxO3a signaling in skeletal muscle

(2012) James P. White et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Skeletal Muscle Apoptotic Signaling Predicts Thigh Muscle Volume and Gait Speed in Community-Dwelling Older Persons: An Exploratory Study

(2012) Emanuele Marzetti et al.   PLoS One

Dihydrotestosterone Ameliorates Degeneration in Muscle, Axons and Motoneurons and Improves Motor Function in Amyotrophic Lateral Sclerosis Model Mice

(2012) Young-Eun Yoo et al.   PLoS One

Testosterone Plus Low-Intensity Physical Training in Late Life Improves Functional Performance, Skeletal Muscle Mitochondrial Biogenesis, and Mitochondrial Quality Control in Male Mice

(2012) Wen Guo et al.   PLoS One

Hypogonadism in the Aging Male Diagnosis, Potential Benefits, and Risks of Testosterone Replacement Therapy

(2012) Prasanth N. Surampudi et al.   International Journal of Endocrinology

Testosterone suppresses oxidative stress via androgen receptor-independent pathway in murine cardiomyocytes

(2011) Xiaowen Xing   Molecular Medicine Reports

Multiple Pathways to the Same End: Mechanisms of Myonuclear Apoptosis in Sarcopenia of Aging

(2011) Emanuele Marzetti et al.   TheScientificWorldJOURNAL

The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double-blind, placebo-controlled phase II trial

(2011) James T. Dalton et al.   Journal of Cachexia Sarcopenia and Muscle

Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People

(2010) A. J. Cruz-Jentoft et al.   AGE AND AGEING

Testosterone-induced hypertrophy of L6 myoblasts is dependent upon Erk and mTOR

(2010) Yong Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MyoD regulates apoptosis of myoblasts through microRNA-mediated down-regulation of Pax3

(2010) Hiroyuki Hirai et al.   JOURNAL OF CELL BIOLOGY

Free Testosterone Levels Are Associated with Mobility Limitation and Physical Performance in Community-Dwelling Men: The Framingham Offspring Study

(2010) Joanne B. Krasnoff et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Prolonged treatment with the anabolic–androgenic steroid stanozolol increases antioxidant defences in rat skeletal muscle

(2010) J. Delgado et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Effects of Testosterone on Skeletal Muscle Architecture in Intermediate-Frail and Frail Elderly Men

(2010) R. A. Atkinson et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Identification of Late-Onset Hypogonadism in Middle-Aged and Elderly Men

(2010) Frederick C.W. Wu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Aberrant Mitochondrial Homeostasis in the Skeletal Muscle of Sedentary Older Adults

(2010) Adeel Safdar et al.   PLoS One

Skeletal muscle wasting in cachexia and sarcopenia: molecular pathophysiology and impact of exercise training

(2010) Karsten Lenk et al.   Journal of Cachexia Sarcopenia and Muscle

Androgens and sexual function: a placebo-controlled, randomized, double-blind study of testosteronevs. dehydroepiandrosterone in men with sexual dysfunction and androgen deficiency

(2009) Alvaro Morales et al.   Aging Male

Testosterone Supplementation Reverses Sarcopenia in Aging through Regulation of Myostatin, c-Jun NH2-Terminal Kinase, Notch, and Akt Signaling Pathways

(2009) Ekaterina L. Kovacheva et al.   ENDOCRINOLOGY

Increased superoxide in vivo accelerates age-associated muscle atrophy through mitochondrial dysfunction and neuromuscular junction degeneration

(2009) Youngmok C. Jang et al.   FASEB JOURNAL

Testosterone induces cardiomyocyte hypertrophy through mammalian target of rapamycin complex 1 pathway

(2009) Francisco Altamirano et al.   JOURNAL OF ENDOCRINOLOGY

Higher Inflammatory Marker Levels in Older Persons: Associations With 5-Year Change in Muscle Mass and Muscle Strength

(2009) L. A. Schaap et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Deficiency of MIP/MTMR14 phosphatase induces a muscle disorder by disrupting Ca2+ homeostasis

(2009) Jinhua Shen et al.   NATURE CELL BIOLOGY

Molecular mechanisms of mTOR-mediated translational control

(2009) Xiaoju Max Ma et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of Myogenic Differentiation by Androgens: Cross Talk between Androgen Receptor/ β-Catenin and Follistatin/Transforming Growth Factor-β Signaling Pathways

(2008) Rajan Singh et al.   ENDOCRINOLOGY

Self-renewal and expansion of single transplanted muscle stem cells

(2008) Alessandra Sacco et al.   NATURE