Journal
FRONTIERS IN GENETICS
Volume 6, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fgene.2015.00077
Keywords
aging; lifespan; pharmacology; GPCR; drug discovery; Caenorhabditis elegans; dietary restriction mimetics
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Funding
- NIH HHS [DP2 OD008398] Funding Source: Medline
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Recent progress in the field of aging has resulted in ever increasing numbers of compounds that extend lifespan in Caenorhabditis elegans. Lifespan extending compounds include metabolites and synthetic compounds, as well as natural products. For many of these compounds, mammalian pharmacology is known, and for some the actual targets have been experimentally identified. In this review, we explore the data available in C. elegans to provide an overview of which pharmacological classes have potential for identification of further compounds that extend lifespan.
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