The aging clock and circadian control of metabolism and genome stability

Circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in rats

(2016) Irina A. Vinogradova et al.   Aging-US

Transposable elements become active and mobile in the genomes of aging mammalian somatic tissues

(2016) Marco De Cecco et al.   Aging-US

The Naked Mole Rat Genome Resource: facilitating analyses of cancer and longevity-related adaptations

(2014) M. Keane et al.   BIOINFORMATICS

Partitioning Circadian Transcription by SIRT6 Leads to Segregated Control of Cellular Metabolism

(2014) Selma Masri et al.   CELL

Melatonin receptor-mediated protection against myocardial ischemia/reperfusion injury: role of SIRT1

(2014) Liming Yu et al.   JOURNAL OF PINEAL RESEARCH

The circadian factor Period 2 modulates p53 stability and transcriptional activity in unstressed cells

(2014) Tetsuya Gotoh et al.   MOLECULAR BIOLOGY OF THE CELL

Potential for genomic instability associated with retrotranspositionally-incompetent L1 loci

(2014) Kristine J. Kines et al.   NUCLEIC ACIDS RESEARCH

Regulation of L1 expression and retrotransposition by melatonin and its receptor: implications for cancer risk associated with light exposure at night

(2014) Dawn deHaro et al.   NUCLEIC ACIDS RESEARCH

Light Exposure at Night Disrupts Host/Cancer Circadian Regulatory Dynamics: Impact on the Warburg Effect, Lipid Signaling and Tumor Growth Prevention

(2014) David E. Blask et al.   PLoS One

Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes

(2014) J. M. C. Tubio et al.   SCIENCE

Sirtuins and the circadian clock: Bridging chromatin and metabolism

(2014) S. Masri et al.   Science Signaling

The aging biological clock inNeurospora crassa

(2014) Mary E. Case et al.   Ecology and Evolution

Large chromosome deletions, duplications, and gene conversion events accumulate with age in normal human colon crypts

(2013) John C. F. Hsieh et al.   AGING CELL

Adverse Health Effects of Nighttime Lighting

(2013) Richard G. Stevens et al.   AMERICAN JOURNAL OF PREVENTIVE MEDICINE

Genome Instability and Aging

(2013) Jan Vijg et al.   Annual Review of Physiology

Breast cancer and circadian disruption from electric lighting in the modern world

(2013) Richard G. Stevens et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Reprogramming of the Circadian Clock by Nutritional Challenge

(2013) Kristin L. Eckel-Mahan et al.   CELL

SIRT1 Mediates Central Circadian Control in the SCN by a Mechanism that Decays with Aging

(2013) Hung-Chun Chang et al.   CELL

High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat

(2013) Xiao Tian et al.   NATURE

Single-Neuron Sequencing Analysis of L1 Retrotransposition and Somatic Mutation in the Human Brain

(2012) Gilad D. Evrony et al.   CELL

The Endogenous Melatonin (MT) Signal Facilitates Reentrainment of the Circadian System to Light-Induced Phase Advances by Acting Upon MT2 Receptors

(2012) Martina Pfeffer et al.   CHRONOBIOLOGY INTERNATIONAL

Extensive somatic L1 retrotransposition in colorectal tumors

(2012) S. Solyom et al.   GENOME RESEARCH

Circadian topology of metabolism

(2012) Joseph Bass   NATURE

Age-Related Changes in the Daily Rhythm of Photoreceptor Functioning and Circuitry in a Melatonin-Proficient Mouse Strain

(2012) Kenkichi Baba et al.   PLoS One

Cancer resistance in the blind mole rat is mediated by concerted necrotic cell death mechanism

(2012) V. Gorbunova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chronic restraint stress attenuates p53 function and promotes tumorigenesis

(2012) Z. Feng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Work at night and breast cancer – report on evidence-based options for preventive actions

(2012) Jens Peter Bonde et al.   SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH

Landscape of Somatic Retrotransposition in Human Cancers

(2012) E. Lee et al.   SCIENCE

Telomere maintenance genes SIRT1 and XRCC6 impact age-related decline in telomere length but only SIRT1 is associated with human longevity

(2011) Sangkyu Kim et al.   BIOGERONTOLOGY

Light at Night Activates IGF-1R/PDK1 Signaling and Accelerates Tumor Growth in Human Breast Cancer Xenografts

(2011) J. Wu et al.   CANCER RESEARCH

Retrotransposition of marked SVA elements by human L1s in cultured cells

(2011) Dustin C. Hancks et al.   HUMAN MOLECULAR GENETICS

Aging of Intrinsic Circadian Rhythms and Sleep in a Diurnal Nonhuman Primate, Macaca mulatta

(2011) I.V. Zhdanova et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Circadian regulation of molecular, dietary, and metabolic signaling mechanisms of human breast cancer growth by the nocturnal melatonin signal and the consequences of its disruption by light at night

(2011) David E. Blask et al.   JOURNAL OF PINEAL RESEARCH

The non-autonomous retrotransposon SVA is trans -mobilized by the human LINE-1 protein machinery

(2011) Julija Raiz et al.   NUCLEIC ACIDS RESEARCH

HRAS1 and LASS1 with APOE are associated with human longevity and healthy aging

(2010) S. Michal Jazwinski et al.   AGING CELL

The Mammalian Circadian Timing System: Organization and Coordination of Central and Peripheral Clocks

(2010) Charna Dibner et al.   Annual Review of Physiology

Declining melatonin levels and MT1 receptor expression in aging rats is associated with enhanced mammary tumor growth and decreased sensitivity to melatonin

(2010) Steven M. Hill et al.   BREAST CANCER RESEARCH AND TREATMENT

PER2 Controls Lipid Metabolism by Direct Regulation of PPARγ

(2010) Benedetto Grimaldi et al.   Cell Metabolism

Systemic DNA Damage Response and Metabolic Syndrome as a Premalignant State

(2010) A. Erol   CURRENT MOLECULAR MEDICINE

Mammalian circadian clock and metabolism - the epigenetic link

(2010) M. M. Bellet et al.   JOURNAL OF CELL SCIENCE

Somatic expression of LINE-1 elements in human tissues

(2010) Victoria P. Belancio et al.   NUCLEIC ACIDS RESEARCH

Regulation of nucleotide excision repair activity by transcriptional and post-transcriptional control of the XPA protein

(2010) T.-H. Kang et al.   NUCLEIC ACIDS RESEARCH

All y’all need to know ‘bout retroelements in cancer

(2010) Victoria P. Belancio et al.   SEMINARS IN CANCER BIOLOGY

Testing the Circadian Gene Hypothesis in Prostate Cancer: A Population-Based Case-Control Study

(2009) Y. Zhu et al.   CANCER RESEARCH

Clock Genes and Cancer

(2009) Patricia A. Wood et al.   INTEGRATIVE CANCER THERAPIES

Molecular Mechanisms of Melatonin Anticancer Effects

(2009) Steven M. Hill et al.   INTEGRATIVE CANCER THERAPIES

A Phylogenetically Conserved DNA Damage Response Resets the Circadian Clock

(2009) Joshua J. Gamsby et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Melatonin preserves longevity protein (sirtuin 1) expression in the hippocampus of total sleep-deprived rats

(2009) Hung-Ming Chang et al.   JOURNAL OF PINEAL RESEARCH

Sirtuins, melatonin and circadian rhythms: building a bridge between aging and cancer

(2009) Brittney Jung-Hynes et al.   JOURNAL OF PINEAL RESEARCH

Circadian oscillation of nucleotide excision repair in mammalian brain

(2009) Tae-Hong Kang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alteration of the MT1 melatonin receptor gene and its expression in primary human breast tumors and breast cancer cell lines

(2008) Ling Lai et al.   BREAST CANCER RESEARCH AND TREATMENT

SIRT1 Regulates Circadian Clock Gene Expression through PER2 Deacetylation

(2008) Gad Asher et al.   CELL

ERCC1/XPF limits L1 retrotransposition

(2008) Stephen L. Gasior et al.   DNA REPAIR

Mammalian non-LTR retrotransposons: For better or worse, in sickness and in health

(2008) V. P. Belancio et al.   GENOME RESEARCH

Relationship Between Calorie Restriction and the Biological Clock: Lessons from Long-Lived Transgenic Mice

(2008) Oren Froy et al.   REJUVENATION RESEARCH