Bioinformatics for precision medicine in oncology: principles and application to the SHIVA clinical trial

Translational research platforms integrating clinical and omics data: a review of publicly available solutions

(2014) V. Canuel et al.   BRIEFINGS IN BIOINFORMATICS

Randomised proof-of-concept phase II trial comparing targeted therapy based on tumour molecular profiling vs conventional therapy in patients with refractory cancer: results of the feasibility part of the SHIVA trial

(2014) C Le Tourneau et al.   BRITISH JOURNAL OF CANCER

PurBayes: estimating tumor cellularity and subclonality in next-generation sequencing data

(2013) Nicholas B. Larson et al.   BIOINFORMATICS

Streamlined ion torrent PGM-based diagnostics: BRCA1 and BRCA2 genes as a model

(2013) Julien Tarabeux et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Building a Personalized Medicine Infrastructure at a Major Cancer Center

(2013) Funda Meric-Bernstam et al.   JOURNAL OF CLINICAL ONCOLOGY

Genomic Medicine Frontier in Human Solid Tumors: Prospects and Challenges

(2013) Rodrigo Dienstmann et al.   JOURNAL OF CLINICAL ONCOLOGY

Precision Oncology: An Overview

(2013) Levi A. Garraway et al.   JOURNAL OF CLINICAL ONCOLOGY

A Clinically Validated Diagnostic Second-Generation Sequencing Assay for Detection of Hereditary BRCA1 and BRCA2 Mutations

(2013) Ian E. Bosdet et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Mutational landscape and significance across 12 major cancer types

(2013) Cyriac Kandoth et al.   NATURE

The Cancer Genome Atlas Pan-Cancer analysis project

(2013) John N Weinstein et al.   NATURE GENETICS

Implementing personalized cancer genomics in clinical trials

(2013) Richard Simon et al.   NATURE REVIEWS DRUG DISCOVERY

First FDA Authorization for Next-Generation Sequencer

(2013) Francis S. Collins et al.   NEW ENGLAND JOURNAL OF MEDICINE

Challenges for implementing next-generation sequencing-based genome diagnostics: it’s also the people, not just the machines

(2013) Joris A Veltman et al.   Personalized Medicine

Personalized medicine: challenges and opportunities for translational bioinformatics

(2013) Casey Lynnette Overby et al.   Personalized Medicine

Clinical trials for precision oncology using next-generation sequencing

(2013) Richard Simon et al.   Personalized Medicine

Comprehensive identification of mutational cancer driver genes across 12 tumor types

(2013) David Tamborero et al.   Scientific Reports

Tissue Banking, Bioinformatics, and Electronic Medical Records: The Front-End Requirements for Personalized Medicine

(2013) K. Stephen Suh et al.   Journal of Oncology

Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration

(2012) H. Thorvaldsdottir et al.   BRIEFINGS IN BIOINFORMATICS

Cancer Genetics and Epigenetics: Two Sides of the Same Coin?

(2012) Jueng Soo You et al.   CANCER CELL

Cancer Epigenetics: From Mechanism to Therapy

(2012) Mark A. Dawson et al.   CELL

The Genetic Basis for Cancer Treatment Decisions

(2012) Janet E. Dancey et al.   CELL

Cancer Genomics: Technology, Discovery, and Translation

(2012) Ben Tran et al.   JOURNAL OF CLINICAL ONCOLOGY

Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR

(2012) Anirudh Prahallad et al.   NATURE

Designs and challenges for personalized medicine studies in oncology: focus on the SHIVA trial

(2012) Christophe Le Tourneau et al.   Targeted Oncology

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

G-CODE: enabling systems medicine through innovative informatics

(2012) Subha Madhavan et al.   GENOME BIOLOGY

Bioinformatics challenges for personalized medicine

(2011) Guy Haskin Fernald et al.   BIOINFORMATICS

BRAFV600E: Implications for Carcinogenesis and Molecular Therapy

(2011) E. R. Cantwell-Dorris et al.   MOLECULAR CANCER THERAPEUTICS

Predictive, personalized, preventive, participatory (P4) cancer medicine

(2011) Leroy Hood et al.   Nature Reviews Clinical Oncology

Mechanisms of mTOR inhibitor resistance in cancer therapy

(2011) Jennifer S. Carew et al.   Targeted Oncology

The real cost of sequencing: higher than you think!

(2011) Andrea Sboner et al.   GENOME BIOLOGY

Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

(2010) Keith T. Flaherty et al.   NEW ENGLAND JOURNAL OF MEDICINE

ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data

(2010) K. Wang et al.   NUCLEIC ACIDS RESEARCH

The case for cloud computing in genome informatics

(2010) Lincoln D Stein   GENOME BIOLOGY

Information management to enable personalized medicine: stakeholder roles in building clinical decision support

(2009) Gregory J Downing et al.   BMC Medical Informatics and Decision Making

Genome Alteration Print (GAP): a tool to visualize and mine complex cancer genomic profiles obtained by SNP arrays

(2009) Tatiana Popova et al.   GENOME BIOLOGY

MapReduce

(2008) Jeffrey Dean et al.   COMMUNICATIONS OF THE ACM