Article
Biochemistry & Molecular Biology
Henriett Butz, Katalin Meszaros, Istvan Liko, Attila Patocs
Summary: The study found that glucocorticoid treatment led to miRNA expression changes in different cell types. 19.5% of the influenced signaling pathways were common in all experiments, with the Wnt signaling pathway being the most affected. Transcriptome data and tissue-specific target prediction showed similar results, indicating significant alterations in the Wnt pathway in both the GC-producing adrenal gland and all investigated GC target tissue types.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Plant Sciences
Regina Mencia, Lucia Gonzalo, Ileana Tossolini, Pablo A. Manavella, Donald Ort
Summary: This review presents the latest progress in the miRNA biogenesis pathway, highlighting the gaps in our knowledge and the unresolved questions in the field. By studying the production of miRNAs in plants, we have identified differences from their metazoan counterpart and discovered several critical factors regulating miRNA biogenesis.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Review
Medicine, Research & Experimental
Risheng Chen, Mingxiu Yang, Weiguo Huang, Baiyun Wang
Summary: Research has shown that miRNAs and lncRNAs play complex roles in regulating the NF-kappa B signaling pathway in gastric cancer, which is crucial for guiding treatment improvements.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Cell Biology
Xiaohui Tan, Shuyang Ren, Canyuan Yang, Shuchang Ren, Melinda Z. Fu, Amelia R. Goldstein, Xuelan Li, Leia Mitchell, Jill M. Krapf, Charles J. Macri, Andrew T. Goldstein, Sidney W. Fu
Summary: Lichen sclerosus (LS) is a chronic inflammatory skin disorder with unknown pathogenesis. Aberrant expression of microRNAs (miRNAs) is considered to play a crucial role in LS. This study identified a total of 170 differentially expressed miRNAs in female LS patients, with 119 upregulated and 51 downregulated, suggesting their potential importance in the pathogenesis of LS. Additionally, molecular network analysis provided further insight into the mechanisms underlying LS.
Review
Medicine, Research & Experimental
Soudeh Ghafouri-Fard, Afete Abak, Faranak Fattahi, Bashdar M. Hussen, Zahra Bahroudi, Hamed Shoorei, Mohammad Taheri
Summary: NF-κB, a group of inducible transcription factors, interacts with miRNAs and lncRNAs to regulate gene expression, playing a crucial role in various diseases, including both neoplastic and nonneoplastic disorders.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Genetics & Heredity
Vrantika Chaudhary, Sumit Jangra, Neelam R. Yadav
Summary: Cluster bean, a drought-tolerant crop with high protein and gum content, was found to have multiple miRNAs and their targets associated with metabolism, biological processes, and stress responses. This study provides valuable information for the identification of miRNAs in cluster bean.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Julia Paczkowska, Joanna Janiszewska, Adam Ustaszewski, Julia Bein, Marcin Skalski, Agnieszka Dzikiewicz-Krawczyk, Natalia Rozwadowska, Martin-Leo Hansmann, Sylvia Hartmann, Maciej Giefing
Summary: Studies have shown that miRNAs play an important role in classical Hodgkin lymphoma (cHL), leading to the loss of B-cell phenotype and NF-kappa B activation. Furthermore, miRNAs regulate this process by targeting B-cell-related transcription factors and NF-kappa B inhibitors.
Review
Genetics & Heredity
Abdollah Jafarzadeh, Havva Marzban, Maryam Nemati, Sara Jafarzadeh, Maryam Mahjoubin-Tehran, Michael R. Hamblin, Hamed Mirzaei, Hamid Reza Mirzaei
Summary: miRNAs play a crucial role in the pathogenesis of ITP by influencing T cell responses and B cell activation, suggesting potential clinical applications. They may serve as biomarkers for ITP, providing more accurate information on prognosis and treatment outcomes.
Review
Biochemistry & Molecular Biology
Yuhai Zhao, Vivian R. Jaber, Aileen Pogue, Nathan M. Sharfman, Christopher Taylor, Walter J. Lukiw
Summary: This article reviews the neurotoxic aspects of lipopolysaccharides (LPSs) and how these pro-inflammatory glycolipids contribute to progressive, age-related and ultimately lethal neurodegenerative disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Ke Wan, Shuyu Chen, Hongyu Zhu, Zhuang Han, Yonggang Liu, Yonghui Zhao, Guosheng Xiong
Summary: Phosphorus (Pi) is vital for plant growth and its uptake is regulated by signaling pathways. SPX domain-containing proteins negatively regulate PHRs and maintain phosphate homeostasis. MiRNAs are expressed under Pi deficiency and their profiles help understand Pi-starvation response regulation. However, the regulation of miRNA expression by SPX-PHR signaling in long-term Pi starvation in rice is still unclear. A genome-wide analysis identified Pi-responsive miRNAs and specific miRNAs between Pi-sufficient and -deficient conditions. These findings provide insights into miRNA functions and genetic improvement of nutrient efficiency in rice.
PLANT GROWTH REGULATION
(2023)
Article
Biotechnology & Applied Microbiology
Paula L. C. Fonseca, Jonathan J. M. Mucherino, Joel A. M. Porto, Juliana N. Armache, Joao Paulo P. de Almeida, Felipe F. da Silva, Roenick P. Olmo, Isaque J. da S. Faria, Daniel S. de Carvalho, Aristoteles Goes-Neto, Ronan X. Correa, Carlos P. Pirovani, Luis G. C. Pacheco, Marco Antonio Costa, Eric R. G. R. Aguiar
Summary: The study identified numerous mite-specific miRNAs in V. destructor, with a prominent role played by bantam in gene expression control. Additionally, signs of miRNA post-transcriptional regulatory mechanisms were observed, indicating the importance of miRNAs in V. destructor. The findings suggest a conservative role for conserved miRNAs in controlling similar processes across different organisms.
Article
Genetics & Heredity
Tong Liu, Jing Tang, Xiaoyu Li, Yuan Lin, Yuma Yang, Kai Ma, Zhaoyuan Hui, Hong Ma, Yanyan Qin, Hetian Lei, Yanhui Yang
Summary: This study identified a potential key network of mRNAs and miRNAs regulated by HIF1A in HCC cells. The dysregulation of these genes and pathways is closely associated with the tumorigenesis of hepatocellular carcinoma and the infiltration levels of tumor-infiltrating immune cells.
FRONTIERS IN GENETICS
(2022)
Review
Immunology
Zilong Wang, Chucun Fang, Mengting Yao, Dongwen Wu, Maga Chen, Tianting Guo, Jianwen Mo
Summary: Venous thromboembolism is a common and costly health problem. Deep-vein thrombosis can cause severe consequences. Inflammatory response is considered an important pathway for triggering venous thromboembolism, and regulating it through the NF-kappa B signaling pathway may provide new solutions for prevention and treatment of thrombosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Hang Yan, Shengjie Tang, Shoujun Tang, Jun Zhang, Haiyang Guo, Chao Qin, Haiyang Hu, Chuan Zhong, Li Yang, Yunhe Zhu, Haining Zhou
Summary: Non-small cell lung cancer (NSCLC) is a common malignant tumor with suboptimal clinical success due to late diagnosis, limited treatment options, high recurrence rates, and drug resistance. MicroRNAs (miRNAs), small non-coding RNAs, have emerged as important players in NSCLC initiation, progression, and drug resistance. This review provides an overview of miRNA dysregulation and resistance in NSCLC and discusses their potential applications in different anti-cancer treatments.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Yu Xiao, Jiaqi Liang, Kenneth W. Witwer, Ying Zhang, Qian Wang, Hang Yin
Summary: In our study, we discovered that extracellular vesicles (EVs) play a crucial role in aging, as they can induce chronic inflammation by activating immune cells. We found that EVs derived from senescent cells contain miR-30b-5p, which downregulates SIRT1 and enhances pro-inflammatory cytokine production. Additionally, we observed increased levels of miR-30b-5p in both the aging animal model and EVs harvested from tissues. EVs carrying pro-inflammatory signals can alter immune cell activity in the aging microenvironment, leading to an increase in inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
