Article
Genetics & Heredity
Cassidy Hemphill, Evye Pylarinou-Sinclair, Omar Itani, Barbara Scott, C. Michael Crowder, Marc Ryan Van Gilst
Summary: In C. elegans, germline ablation leads to enhanced resistance to hypoxia. This resistance is dependent on developmental stage and age, and is mediated by signals from somatic tissues. Two mechanisms of hypoxia resistance in germline deficient animals were identified, with one being DAF-16/FoxO independent and the other being DAF-16/FoxO dependent. The repression of cytosolic ribosomal protein genes by DAF-16/FoxO was found to be a mechanism of hypoxia super-resistance.
Article
Biochemistry & Molecular Biology
Zhongliang Hu, Yamei Luo, Yuting Liu, Yaru Luo, Liangce Wang, Shengsong Gou, Yuling Peng, Rui Wei, Da Jia, Yuan Wang, Shangbang Gao, Yan Zhang
Summary: The increase in global life expectancy is not accompanied by an increase in health span, requiring a better understanding of age-related decline in behavior. A genome-wide screening in Caenorhabditis elegans identified 34 genes as potential regulators of motor aging, with VPS-34 being crucial in aged but not young worms. This phosphatidylinositol 3-kinase primarily functions in aged motor neurons by regulating neurotransmission, and inhibition of VPS-34 improves motor aging in worms and mice.
Article
Cell Biology
Alfonso Schiavi, Claudia Cirotti, Lora-Sophie Gerber, Giulia Di Lauro, Silvia Maglioni, Priscila Yumi Tanaka Shibao, Sabrina Montresor, Janine Kirstein, Patrick Petzsch, Karl Koehrer, Roel P. F. Schins, Tina Wahle, Daniela Barila, Natascia Ventura
Summary: Alzheimer's disease, the most common age-associated neurodegenerative disorder, can be effectively combated by the natural compound quercetin. In this study, the nematode model Caenorhabditis elegans was used to demonstrate the beneficial effects of quercetin against Alzheimer's pathology. Quercetin was found to reduce Aβ secretion and protect against Aβ toxicity through autophagy-dependent suppression of Abl tyrosine kinase.
CELL DEATH DISCOVERY
(2023)
Article
Multidisciplinary Sciences
Peter E. Lillis, Christine T. Griffin, James C. Carolan
Summary: In this study, the proteome changes of two distantly related EPN species were investigated under different storage temperatures and durations. The results showed that the proteome of S. carpocapsae was strongly affected by temperature, while the proteome of H. megidis was affected by both time and temperature. These findings suggest species-specific adaptation mechanisms to storage conditions.
