Article
Cell Biology
Xiaolin Lin, Ting Han, Qing Xia, Jiujie Cui, Meng Zhuo, Yiyi Liang, Wenyu Su, Lisha Wang, Liwei Wang, Zebing Liu, Xiuying Xiao
Summary: CHPF is upregulated in gastric cancer tissues and correlates with tumor infiltration, advanced tumor stage, and shorter patient survival. It may promote gastric cancer development by regulating cell proliferation, colony formation, cell apoptosis, and cell migration, with knockdown inducing opposite effects. Additionally, CHPF may regulate E2F1 through affecting UBE2T-mediated E2F1 ubiquitination.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Shanting Gao, Xiaomin Bu, Yongyue Gao, Zengtao Bao, Wenchao Shi, Lipeng Luan, Huiyu Chen, Baoming Zhang, Qingshui Tian, Wenxian Guan, Liuqing Yang
Summary: This study reveals the significant roles of the E2F1-miR-532 double-negative feedback loop in gastric cancer progression. E2F1 is highly upregulated in gastric cancer tissues and correlates with tumor malignancy. MiR-532 is decreased and negatively correlated with E2F1 in gastric cancer tissues. MiR-532 directly targets and inhibits E2F1 expression, affecting proliferation, cell cycle, apoptosis, and DNA damage in gastric cancer cells. Moreover, E2F1 serves as a transcriptional repressor to suppress miR-532 expression, forming a double-negative feedback loop.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Dae-Hwan Kim, Duanchen Sun, William K. Storck, Katherine Welker Leng, Chelsea Jenkins, Daniel J. Coleman, David Sampson, Xiangnan Guan, Anbarasu Kumaraswamy, Eva S. Rodansky, Joshua A. Urrutia, Jacob A. Schwartzman, Chao Zhang, Himisha Beltran, Mark P. Labrecque, Colm Morrissey, Jared M. Lucas, Ilsa M. Coleman, Peter S. Nelson, Eva Corey, Samuel K. Handelman, Jonathan Z. Sexton, Rahul Aggarwal, Wassim Abida, Felix Y. Feng, Eric J. Small, Daniel E. Spratt, Armand Bankhead, Arvind Rao, Emily M. Gesner, Sarah Attwell, Sanjay Lakhotia, Eric Campeau, Joel A. Yates, Zheng Xia, Joshi J. Alumkal
Summary: NEPC is the most aggressive lineage plasticity in prostate cancer, with limited treatment options. By inhibiting AR and using BET inhibitors, it is possible to block this lineage plasticity, showing promising potential for t-NEPC treatment.
CLINICAL CANCER RESEARCH
(2021)
Article
Multidisciplinary Sciences
Xiaodong Wang, Ying Chen, Yunshu Gao, Huiqing Zhang, Zehui Guan, Zhou Dong, Yuxuan Zheng, Jiarui Jiang, Haoqing Yang, Liming Wang, Xianming Huang, Lirong Ai, Wenlong Yu, Hongwei Li, Changsheng Dong, Zhou Zhou, Xiyang Liu, Guanzhen Yu
Summary: The study proposes a deep-learning framework to analyze lymph node whole-slide images, identifying lymph nodes and tumor regions, and revealing the importance of the tumor-area-to-MLN-area ratio (T/MLN) in predicting the prognosis of gastric cancer patients.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Jianming Zhang, Jing Zhang, Zhongmao Fu, Yuan Zhang, Zai Luo, Pengshan Zhang, Yitian Xu, Chen Huang
Summary: Accumulating evidence suggests that downregulation of carbohydrate response element binding protein (CHREBP) is associated with gastric cancer (GC) development and progression. CHREBP acts as an independent diagnostic marker of GC and its downregulation promotes cell proliferation and inhibits apoptosis. Furthermore, CHREBP transcriptionally inhibits cyclin D1 expression in GC cells, suggesting its involvement in GC growth and apoptosis through targeting the cyclin D1-Rb-E2F1 pathway.
CELL DEATH DISCOVERY
(2022)
Article
Oncology
Jinglin Zhang, Bonan Chen, Yifei Wang, Xiaoli Liu, Huan Yan, Kit Yee Wong, Aden K. Y. Chan, Alvin H. K. Cheung, Chit Chow, Dazhi Xu, Shouyu Wang, Bing Huang, Li Liang, Huixing Ke, Chi Chun Wong, William K. K. Wu, Alfred S. L. Cheng, Jun Yu, Kwok Wai Lo, Ka Fai To, Wei Kang
Summary: This study reveals the oncogenic role of HOXB9 in gastric cancer and identifies CDK6 as its downstream effector. The E2F1-HOXB9/PBX2-CDK6 axis represents a novel mechanism driving gastric carcinogenesis and has prognostic and therapeutic implications.
JOURNAL OF PATHOLOGY
(2023)
Review
Oncology
Itaru Hashimoto, Takashi Oshima
Summary: This review highlights the biological and clinical significance of claudin (CLDN) expression in gastric cancer (GC), with a focus on CLDN18.2 and clinical trials centered around it. Abnormal expression of CLDNs, particularly CLDN18, is observed in GC. CLDNs are potential targets for antibody drugs in GC treatment.
Article
Medicine, General & Internal
Hisaki Aiba, Tomoharu Nakazato, Hideo Matsuo, Hiroaki Kimura, Shiro Saito, Takao Sakai, Hideki Murakami, Jun Kawai, Shingo Kawasaki, Yasuhiro Imamura
Summary: Systemic osteosclerotic lesions are rare complications of gastric cancer, typically caused by multiple bone metastases or systemic metabolic disorders. This case report describes a rare case of gastric cancer recurrence presenting with mixed osteoblastic and osteolytic bone lesions resembling Paget's disease. Accurate diagnosis was achieved through bone biopsy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Ran Wang, Wei Huang, Kaimei Cai, Shihan Xiao, Wuming Zhang, Xianqin Hu, Jianping Guo, Linfeng Mao, Weijie Yuan, Yi Xu, Zihua Chen, Zhikang Chen, Chen Lai
Summary: Flotillin-1 (FLOT1) promotes gastric cancer progression and metastasis through interaction with BCAR1 via ERK signaling. FLOT1 regulates BCAR1 phosphorylation and translocation, and BCAR1 knockdown blocks FLOT1-induced gastric cancer cell proliferation, migration, and invasion. Moreover, the expression of FLOT1 and BCAR1 is closely related to poor prognosis in gastric cancer patients.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Zhonghua Wu, Bicheng Qu, Minxian Yuan, Jingjing Liu, Cen Zhou, Mingwei Sun, Zhexu Guo, Yaqing Zhang, Yongxi Song, Zhenning Wang
Summary: The overexpression of cysteine-rich intestinal protein-1 (CRIP1) in gastric cancer promotes lymphangiogenesis and lymphatic vessel permeability, leading to lymphatic metastasis. This study uncovers the role and mechanism of CRIP1 in mediating gastric cancer lymphatic metastasis, providing potential targets for future therapeutics.
Article
Multidisciplinary Sciences
Xiaolin Wang, Jingxin Li, Xing Bian, Cheng Wu, Jinghan Hua, Shuhui Chang, Tianyi Yu, Hong Li, Yongxiang Li, Shanshan Hu, Ge Shan, Wenchu Lin
Summary: The study identified circURI7 as a circRNA with significantly higher expression in gastric cancer, which inhibits cell migration and invasion by modulating alternative splicing of genes involved in the process of cell migration, thus suppressing GC metastasis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Oncology
Hailong Shi, Yuanyuan Cheng, Qimei Shi, Wenzhi Liu, Xue Yang, Shuang Wang, Lin Wei, Xiangming Chen, Hao Fang
Summary: Myoferlin is a newly identified oncogene that is associated with tumor metastasis, intracellular ROS production, and energy metabolism. Its function in regulating gastric cancer cell migration and ROS accumulation has not been determined.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Priyanka Priyanka, Madhur Sharma, Sanjeev Das, Sandeep Saxena
Summary: E2F1 induces the expression of lncRNA EMSLR in lung adenocarcinoma and lung squamous cell carcinoma, and it is involved in regulating cell proliferation and differentiation signaling pathways. EMSLR functions by repressing the promoter activity of LncPRESS1, and C-MYC plays a role in the regulation network of EMSLR and LncPRESS1.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Huanhuan Li, Fan Tong, Rui Meng, Ling Peng, Jiaojiao Wang, Ruiguang Zhang, Xiaorong Dong
Summary: In this study, WNT5A protein was found to be significantly downregulated in BM tissues and EGFR-mutant samples of NSCLC patients, with overexpression inhibiting the growth and migration of EGFR-mutant cells. Further research revealed that WNT5A is negatively regulated by E2F1 and that its repression is dependent on the ERK1/2 pathway in EGFR-mutant cells. These findings suggest that targeting the ERK1/2-E2F1-WNT5A pathway could be an effective strategy for treating BM in EGFR-mutant NSCLC.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Oncology
Noriyuki Nishiwaki, Tomoyuki Irino, Keiichi Fujiya, Satoshi Kamiya, Makoto Hikage, Yutaka Tanizawa, Etsuro Bando, Kimihide Kusafuka, Masanori Terashima
Summary: The study aimed to clarify the clinicopathological characteristics and prognostic relevance of extra-nodal metastasis (ENM) in gastric cancer patients undergoing curative gastrectomy. Results showed that ENM was an independent prognostic factor with a prognostic significance different from that of lymph node metastasis.