Journal
MATERIALS & DESIGN
Volume 88, Issue -, Pages 1127-1133Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.matdes.2015.09.069
Keywords
Cancer; Drug delivery; Mesoporous materials; Multilayers; Layer-by-layer assembly; Polyamidoamine dendrimer
Categories
Funding
- National Natural Science Foundation of China [51273086]
- Special Doctorial Program Fund from the Ministry of Education of China [20130211110017]
- Fundamental Research Funds for the Central Universities [lzujbky-2013-64]
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To overcome serious limitations encountered by mesoporous silica nanoparticle (MSN) and dendrimers used alone, and to further enhance their performance for application in cancer treatment, multifunctional mesoporous silica nanoparticles as nanocarriers were prepared by layer-by-layer assembly method, with biocompatible Polyamidoamine (PAMAM) dendrimers and chondroitin sulfate (CS). Due to being incorporated to MSN, PAMAM dendrimers can avoid the fast clearance. Attributing to the multilayer coating of PAMAM dendrimers and CS, the nanocarriers possess self-fluorescent property, avoiding the use of fluorescent labels and enabling to release drugs responded to pH. Furthermore, chondroitin sulfate, a natural polysaccharide found in bone, cartilage, and connective tissue, can be served as linking points to bring dendrimers together, and enhance the delivery performance via its targeting ability. (C) 2015 Elsevier Ltd. All rights reserved.
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