Role of TGF-β signaling in inherited and acquired myopathies

Targeting the Activin Type IIB Receptor to Improve Muscle Mass and Function in the mdx Mouse Model of Duchenne Muscular Dystrophy

(2011) Emidio E. Pistilli et al.   AMERICAN JOURNAL OF PATHOLOGY

Losartan Decreases Cardiac Muscle Fibrosis and Improves Cardiac Function in Dystrophin-Deficient Mdx Mice

(2011) Christopher F. Spurney et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Antibody-Directed Myostatin Inhibition Improves Diaphragm Pathology in Young but not Adult Dystrophic mdx Mice

(2010) Kate T. Murphy et al.   AMERICAN JOURNAL OF PATHOLOGY

Acute daily psychological stress causes increased atrophic gene expression and myostatin-dependent muscle atrophy

(2010) David L. Allen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival

(2010) Xiaolan Zhou et al.   CELL

TNF/p38α/Polycomb Signaling to Pax7 Locus in Satellite Cells Links Inflammation to the Epigenetic Control of Muscle Regeneration

(2010) Daniela Palacios et al.   Cell Stem Cell

Mitogen-Activated Protein Kinase Inhibitors Improve Heart Function and Prevent Fibrosis in Cardiomyopathy Caused by Mutation in Lamin A/C Gene

(2010) Wei Wu et al.   CIRCULATION

Direct effects of the pathogenic mutation on satellite cell function in muscular dystrophy

(2010) Jennifer E. Morgan et al.   EXPERIMENTAL CELL RESEARCH

Regulation and dysregulation of fibrosis in skeletal muscle

(2010) Antonio L. Serrano et al.   EXPERIMENTAL CELL RESEARCH

Antibody-directed myostatin inhibition in 21-mo-old mice reveals novel roles for myostatin signaling in skeletal muscle structure and function

(2010) Kate T. Murphy et al.   FASEB JOURNAL

Functional muscle analysis of the Tcap knockout mouse

(2010) C. D. Markert et al.   HUMAN MOLECULAR GENETICS

Administration of a soluble activin type IIB receptor promotes skeletal muscle growth independent of fiber type

(2010) Samuel M. Cadena et al.   JOURNAL OF APPLIED PHYSIOLOGY

Myostatin expression is increased by food deprivation in a muscle-specific manner and contributes to muscle atrophy during prolonged food deprivation in mice

(2010) David L. Allen et al.   JOURNAL OF APPLIED PHYSIOLOGY

Disrupted Transforming Growth Factor-  Signaling in Spinal and Bulbar Muscular Atrophy

(2010) M. Katsuno et al.   JOURNAL OF NEUROSCIENCE

p38 MAPK Participates in Muscle-Specific RING Finger 1-Mediated Atrophy in Cast-Immobilized Rat Gastrocnemius Muscle

(2010) Junghwan Kim et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Myostatin up-regulation is associated with the skeletal muscle response to hypoxic stimuli

(2010) Maurice Hayot et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Hindlimb skeletal muscle function in myostatin-deficient mice

(2010) Bettina A. Gentry et al.   MUSCLE & NERVE

Fibrosis inhibition and muscle histopathology improvement in laminin-α2-deficient mice

(2010) Yoram Nevo et al.   MUSCLE & NERVE

Activin IIB receptor blockade attenuates dystrophic pathology in a mouse model of duchenne muscular dystrophy

(2010) Kevin J. Morine et al.   MUSCLE & NERVE

Prevention of muscle fibrosis and myonecrosis inmdxmice by suramin, a TGF-β1 blocker

(2010) Ana Paula Tiemi Taniguti et al.   MUSCLE & NERVE

Systemic Myostatin Inhibition via Liver-Targeted Gene Transfer in Normal and Dystrophic Mice

(2010) Kevin J. Morine et al.   PLoS One

Muscle Wasting and Impaired Myogenesis in Tumor Bearing Mice Are Prevented by ERK Inhibition

(2010) Fabio Penna et al.   PLoS One

Recombinant Myostatin (GDF-8) Propeptide Enhances the Repair and Regeneration of Both Muscle and Bone in a Model of Deep Penetrant Musculoskeletal Injury

(2010) Mark W. Hamrick et al.   JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE

Relative roles of TGF-β1 and Wnt in the systemic regulation and aging of satellite cell responses

(2009) Morgan E. Carlson et al.   AGING CELL

Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size

(2009) Anne Ulrike Trendelenburg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Acute inhibition of myostatin-family proteins preserves skeletal muscle in mouse models of cancer cachexia

(2009) Margaret E. Benny Klimek et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Different atrophy-hypertrophy transcription pathways in muscles affected by severe and mild spinal muscular atrophy

(2009) Caterina Millino et al.   BMC Medicine

Altered production of extra-cellular matrix components by muscle-derived Duchenne muscular dystrophy fibroblasts before and after TGF-β1 treatment

(2009) Simona Zanotti et al.   CELL AND TISSUE RESEARCH

Deacetylase Inhibitors Modulate the Myostatin/Follistatin Axis without Improving Cachexia in Tumor-Bearing Mice

(2009) A. Bonetto et al.   CURRENT CANCER DRUG TARGETS

Molecular aging and rejuvenation of human muscle stem cells

(2009) Morgan E. Carlson et al.   EMBO Molecular Medicine

A soluble activin type IIB receptor improves function in a mouse model of amyotrophic lateral sclerosis

(2009) Brett M. Morrison et al.   EXPERIMENTAL NEUROLOGY

Inhibition of myostatin does not ameliorate disease features of severe spinal muscular atrophy mice

(2009) Charlotte J. Sumner et al.   HUMAN MOLECULAR GENETICS

Osteopontin promotes fibrosis in dystrophic mouse muscle by modulating immune cell subsets and intramuscular TGF-β

(2009) Sylvia A. Vetrone et al.   JOURNAL OF CLINICAL INVESTIGATION

Latent TGF-β–binding protein 4 modifies muscular dystrophy in mice

(2009) Ahlke Heydemann et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular, cellular and physiological investigation of myostatin propeptide-mediated muscle growth in adult mice

(2009) Antonios Matsakas et al.   NEUROMUSCULAR DISORDERS

Functional resolution of fibrosis in mdx mouse dystrophic heart and skeletal muscle by halofuginone

(2008) Kyla D. Huebner et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Improved Muscle Healing after Contusion Injury by the Inhibitory Effect of Suramin on Myostatin, a Negative Regulator of Muscle Growth

(2008) Masahiro Nozaki et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Angiotensin II Receptor Blockade Administered after Injury Improves Muscle Regeneration and Decreases Fibrosis in Normal Skeletal Muscle

(2008) Hany S. Bedair et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Signaling cross-talk between TGF-β/BMP and other pathways

(2008) Xing Guo et al.   CELL RESEARCH

Non-Smad pathways in TGF-β signaling

(2008) Ying E Zhang   CELL RESEARCH

Muscle myostatin signalling is enhanced in experimental cancer cachexia

(2008) P. Costelli et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Fibrinogen drives dystrophic muscle fibrosis via a TGF /alternative macrophage activation pathway

(2008) B. Vidal et al.   GENES & DEVELOPMENT

Myostatin Propeptide Gene Delivery by Adeno-Associated Virus Serotype 8 Vectors Enhances Muscle Growth and Ameliorates Dystrophic Phenotypes in mdx Mice

(2008) Chunping Qiao et al.   HUMAN GENE THERAPY

Delivery of recombinant follistatin lessens disease severity in a mouse model of spinal muscular atrophy

(2008) Ferrill F. Rose et al.   HUMAN MOLECULAR GENETICS

Osteopontin and skeletal muscle myoblasts: Association with muscle regeneration and regulation of myoblast function in vitro

(2008) Kitipong Uaesoontrachoon et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Myostatin Directly Regulates Skeletal Muscle Fibrosis

(2008) Zhao Bo Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells

(2008) Morgan E. Carlson et al.   NATURE

Prevention of muscle fibrosis and improvement in muscle performance in the mdx mouse by halofuginone

(2008) Tidhar Turgeman et al.   NEUROMUSCULAR DISORDERS

Long-term enhancement of skeletal muscle mass and strength by single gene administration of myostatin inhibitors

(2008) A. M. Haidet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Sarcopenia Reveals an Increase in SOCS-3 and Myostatin and a Reduced Efficiency of Akt Phosphorylation

(2008) Bertrand Léger et al.   REJUVENATION RESEARCH

Connective tissue growth factor is overexpressed in muscles of human muscular dystrophy

(2007) Guilian Sun et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Myostatin blockade improves function but not histopathology in a murine model of limb-girdle muscular dystrophy 2C

(2007) Sasha Bogdanovich et al.   MUSCLE & NERVE