Review
Biology
Timur M. Mirzoev
Summary: Cell mechanotransduction is the ability of cells to detect physical forces and convert them into biochemical events. Mechanosensors, including ion channels, play a crucial role in this process. Activation of mechanically activated (MA) or stretch-activated (SA) channels is important for muscle protein synthesis and fiber hypertrophy in response to mechanical stimulation. However, the role of MA channels in intracellular signaling pathways regulating muscle protein synthesis is not well understood. This review article aims to discuss the regulation and potential roles of MA channels in striated muscle during anabolic processes in response to mechanical stimuli.
Review
Cell Biology
Luisa Gorza, Matteo Sorge, Laura Secli, Mara Brancaccio
Summary: Muscle atrophy development can be partially antagonized by targeting the Atrogene pathway, but may have limited effects in different contexts. Costameres, as macromolecular complexes, play a crucial role in sensing mechanical load and transducing it into biochemical signals to regulate muscle mass.
Article
Biochemistry & Molecular Biology
Baojun Sun, Hitomi Maruta, Yun Ma, Hiromi Yamashita
Summary: Taurine is an abundant free amino acid in mammalian tissues that plays a role in skeletal muscle function and exercise capacity. This study investigated the mechanism of taurine function in skeletal muscles by examining the effects of short-term administration of taurine on rats and L6 cells. The results suggest that taurine modulates skeletal muscle function by activating AMP-activated protein kinase through the calcium signaling pathway, leading to the expression of genes and proteins associated with mitochondrial and respiratory metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Deirdre D. Scripture-Adams, Kevin N. Chesmore, Florian Barthelemy, Richard T. Wang, Shirley Nieves-Rodriguez, Derek W. Wang, Ekaterina Mokhonova, Emilie D. Douine, Jijun Wan, Isaiah Little, Laura N. Rabichow, Stanley F. Nelson, M. Carrie Miceli
Summary: This study develops a method to isolate and sequence individual nuclei from frozen muscle, allowing for the exploration of cellular and transcriptomic mechanisms in Duchenne muscular dystrophy. The findings reveal the effects of exon skipping therapy on muscle nuclei and demonstrate partial rescue of muscle fibers, expansion of myeloid population, recovery of M2 macrophages, and repression of inflammatory fibroblasts.
COMMUNICATIONS BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Simranjot Bawa, Rosanna Piccirillo, Erika R. Geisbrecht
Summary: TRIM32 is a multifunctional protein involved in differentiation, muscle physiology, and tumor suppression, with mutations leading to diverse clinical diseases. It acts as a tumor suppressor but paradoxically is overexpressed in certain cancers.
Review
Physiology
Susan Wray, Clodagh Prendergast, Sarah Arrowsmith
Summary: This study explores the mechanisms of calcium-activated chloride channels in smooth muscle tissues and the differences in their activation and regulation in different types of smooth muscles. The findings suggest that the expression and functional importance of CaCC vary in different smooth muscle tissues, with more complexity in activation and regulation observed in vascular smooth muscles.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cell Biology
Albert C. Sek, Caroline M. Percopo, Arun K. Boddapati, Michelle Ma, Wendy E. Geslewitz, Julia O. Krumholz, Justin B. Lack, Helene F. Rosenberg
Summary: Eosinophils are no longer considered simply as cytotoxic effectors, but as complex cells with unique phenotypes that respond to stimuli in the local microenvironment. RNA sequencing revealed up-regulation of tissue remodeling genes in eosinophils from dystrophin-deficient mdx mice, and effector proteins in eosinophils from IL5tg mice without muscle lesions. Additionally, the immunomodulatory receptor Trem2 was found to be critical for eosinophil growth and differentiation, with expression correlating with donor characteristics in human peripheral blood eosinophils.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Article
Biology
Blanca Calle-Ciborro, Teresa Espin-Jaime, Francisco J. Santos, Ana Gomez-Martin, Isaac Jardin, Maria J. Pozo, Juan A. Rosado, Pedro J. Camello, Cristina Camello-Almaraz
Summary: Skeletal muscle releases hormones called myokines, which interact with other organs and mediate the effects of physical activity. The release of interleukin 6 (IL-6), a myokine involved in inflammation, immunity, and metabolism, from muscle cells is not well understood. This study investigated the role of calcium ions in the release of IL-6 from human muscle cells and found that proteins responsible for calcium increase during stimulation induce IL-6 release. These findings could provide insights into the release of IL-6 and other myokines in pathological conditions.
Article
Multidisciplinary Sciences
David E. Lee, Lauren K. McKay, Akshay Bareja, Yongwu Li, Alastair Khodabukus, Nenad Bursac, Gregory A. Taylor, Gurpreet S. Baht, James P. White
Summary: Pathologies associated with sarcopenia include decline in muscular strength, lean mass and regenerative capacity. This study investigates the therapeutic potential of METRNL to improve aged muscle through improving muscle regeneration and countering age-related loss in muscle resilience by triggering apoptosis of fibro/adipogenic progenitor cells.
NATURE COMMUNICATIONS
(2022)
Review
Physiology
Kunal R. Shah, Xin Guan, Jiusheng Yan
Summary: Ion channels can form macromolecular signaling complexes to ensure accurate signal transduction. The BK channel limits increases in [Ca2+]i levels through K+ efflux and rapid membrane repolarization, serving as a negative feedback regulator.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Toshiko Yamazawa, Takuya Kobayashi, Nagomi Kurebayashi, Masato Konishi, Satoru Noguchi, Takayoshi Inoue, Yukiko U. Inoue, Ichizo Nishino, Shuichi Mori, Hiroto Iinuma, Noriaki Manaka, Hiroyuki Kagechika, Arkady Uryash, Jose Adams, Jose R. Lopez, Xiaochen Liu, Christine Diggle, Paul D. Allen, Sho Kakizawa, Keigo Ikeda, Bangzhong Lin, Yui Ikemi, Kazuto Nunomura, Shinsaku Nakagawa, Takashi Sakurai, Takashi Murayama
Summary: The study shows that an oxolinic acid-derivative RyR1 inhibitor can effectively prevent and treat various malignant hyperthermia (MH) and heat stroke mouse models.
NATURE COMMUNICATIONS
(2021)
Review
Pharmacology & Pharmacy
Yan Yan, Ming Li, Jie Lin, Yanan Ji, Kexin Wang, Dajun Yan, Yuntian Shen, Wei Wang, Zhongwei Huang, Haiyan Jiang, Hualin Sun, Lei Qi
Summary: This review summarizes the role of AMPK in regulating mitochondrial function and its impact on skeletal muscle metabolism and health.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Angus Lindsay, Adam J. Trewin, Kate J. Sadler, Claire Laird, Paul A. Della Gatta, Aaron P. Russell
Summary: The study found that stress-resistant mdx mice show higher activity levels and better physiological function in response to behavioral stress, including greater exercise and muscle oxidative capacity, as well as less severe muscle histopathology. Female mdx mice exhibit higher activity levels following behavioral stress compared to males, a response that can be eliminated after ovariectomy but restored with estradiol.
Article
Cell Biology
Christine T. Nguyen, Majid Ebrahimi, Penney M. Gilbert, Bryan A. Stewart
Summary: This study analyzed the electrophysiological characteristics of healthy and diseased three-dimensional bioengineered skeletal muscle tissues, focusing on Duchenne muscular dystrophy. The research also tested a potential therapeutic compound and showed improvement in membrane potential in dystrophic muscle, laying the foundation for examining potential therapies for muscular disorders in vitro.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Juan J. Ferreira, Chinwendu Amazu, Lis C. Puga-Molina, Xiaofeng Ma, Sarah K. England, Celia M. Santi
Summary: Depolarization of the myometrial smooth muscle cell (MSMC) resting membrane potential is crucial for the transition from a quiescent to a contractile state in the uterus, with a coupled system between the Na+-activated K+ channel (SLO2.1) and the non-selective Na+ leak channel (NALCN) playing a key role. The activation of SLO2.1 by Na+ entering through NALCN leads to potassium efflux and membrane hyperpolarization, while a decrease in SLO2.1/NALCN activity induces membrane depolarization and triggers Ca2+ entry for contraction. The close proximity of NALCN and SLO2.1 in human MSMCs allows for functional regulation of membrane potential, cell excitability, and uterine contractility.
Article
Physiology
Angus Lindsay, Alexie A. Larson, Mayank Verma, James M. Ervasti, Dawn A. Lowe
JOURNAL OF APPLIED PHYSIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Angus Lindsay, William M. Southern, Preston M. McCourt, Alexie A. Larson, James S. Hodges, Dawn A. Lowe, James M. Ervasti
Article
Cell Biology
Brittany C. Collins, Robert W. Arpke, Alexie A. Larson, Cory W. Baumann, Ning Xie, Christine A. Cabelka, Nardina L. Nash, Hanna-Kaarina Juppi, Eija K. Laakkonen, Sarianna Sipila, Vuokko Kovanen, Espen E. Spangenburg, Michael Kyba, Dawn A. Lowe
Article
Sport Sciences
Cory W. Baumann, Gordon L. Warren, Dawn A. Lowe
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2020)
Article
Cell Biology
Angus Lindsay, Cory W. Baumann, Robyn T. Rebbeck, Samantha L. Yuen, William M. Southern, James S. Hodges, Razvan L. Cornea, David D. Thomas, James M. Ervasti, Dawn A. Lowe
Article
Medicine, Research & Experimental
Darko Bosnakovski, Ahmed S. Shams, Ce Yuan, Meiricris T. da Silva, Elizabeth T. Ener, Cory W. Baumann, Angus J. Lindsay, Mayank Verma, Atsushi Asakura, Dawn A. Lowe, Michael Kyba
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Article
Endocrinology & Metabolism
Melissa R. Inigo, Adam J. Amorese, Michael D. Tarpey, Nicholas P. Balestrieri, Keith G. Jones, Daniel J. Patteson, Kathryn C. Jackson, Maria J. Torres, Chien-Te Lin, Cody D. Smith, Timothy D. Heden, Shawna L. McMillin, Luke A. Weyrauch, Erin C. Stanley, Cameron A. Schmidt, Brita B. Kilburg-Basnyat, Sky W. Reece, Christine E. Psaltis, Leslie A. Leinwand, Katsu Funai, Joseph M. McClung, Kymberly M. Gowdy, Carol A. Witczak, Dawn A. Lowe, P. Darrell Neufer, Espen E. Spangenburg
MOLECULAR METABOLISM
(2020)
Editorial Material
Endocrinology & Metabolism
Dawn A. Lowe, Georgios Kararigas
FRONTIERS IN ENDOCRINOLOGY
(2020)
Article
Cell Biology
Lien A. Phung, Aurora D. Foster, Mark S. Miller, Dawn A. Lowe, David D. Thomas
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2020)
Article
Physiology
Alexie A. Larson, Cory W. Baumann, Michael Kyba, Dawn A. Lowe
EXPERIMENTAL PHYSIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
D'anna M. Nelson, Elizabeth K. Fasbender, Margurite C. Jakubiak, Angus Lindsay, Dawn A. Lowe, James M. Ervasti
Article
Neurosciences
Jacob A. Ross, Hichem Tasfaout, Yotam Levy, Jennifer Morgan, Belinda S. Cowling, Jocelyn Laporte, Edmar Zanoteli, Norma B. Romero, Dawn A. Lowe, Heinz Jungbluth, Michael W. Lawlor, David L. Mack, Julien Ochala
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Angus Lindsay, John Holm, Maria Razzoli, Alessandro Bartolomucci, James M. Ervasti, Dawn A. Lowe
Summary: Research shows that mdx mice do not habituate to mild stress, and daily exposure to mild stress for weeks exacerbates phenotypes associated with dystrophinopathy in mdx mice.
Article
Cell Biology
Mina P. Peyton, Tzu-Yi Yang, LeeAnn Higgins, Todd W. Markowski, Cha Vue, Laurie L. Parker, Dawn A. Lowe
Summary: Protein phosphorylation plays a crucial role in skeletal muscle development, growth, regeneration, and contraction. This study provides the first global phosphoproteomic analysis in females and demonstrates that estrogen deficiency can impact the skeletal muscle phosphoproteome.
PHYSIOLOGICAL GENOMICS
(2022)
Article
Physiology
Gengyun Le, Cory W. Baumann, Gordon L. Warren, Dawn A. Lowe
Summary: This study developed a novel method to measure muscle strength in female mice, and found that estradiol enhances posttetanic twitch potentiation (PTP) through the G-protein estrogen receptor (GPER) signaling rather than ERa or ERss signaling pathways. These findings indicate the importance of GPER in mediating the effects of estradiol on muscle strength in female mice.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)