Article
Biochemistry & Molecular Biology
Paulo H. C. Mesquita, Donald A. Lamb, Joshua S. Godwin, Shelby C. Osburn, Bradley A. Ruple, Johnathon H. Moore, Christopher G. Vann, Kevin W. Huggins, Andrew D. Fruge, Kaelin C. Young, Andreas N. Kavazis, Michael D. Roberts
Summary: The study found that 6 weeks of resistance training reduced oxidative damage and increased antioxidant enzyme activities in skeletal muscle of older adults. The responses of older adults to resistance training involve multi-level control (transcriptional, post-transcriptional, and post-translational) of the redox status of skeletal muscle.
Review
Biochemistry & Molecular Biology
Olga Vasileiadou, George G. Nastos, Panagiotis N. Chatzinikolaou, Dimitrios Papoutsis, Dimitra I. Vrampa, Spyridon Methenitis, Nikos V. Margaritelis
Summary: Mammalian skeletal muscles exhibit different redox properties and antioxidant enzyme activities between slow-twitch and fast-twitch muscles. Slow-twitch muscles have higher antioxidant enzyme activity, while fast-twitch muscles have higher oxidative production. This redox heterogeneity may have implications for muscle function and health research and provide an explanation for conflicting results about antioxidant supplement efficacy.
Article
Biochemistry & Molecular Biology
Enrique Cadenas, Helmut Sies
Summary: Lester Packer, an inspirational scientific leader, had a profound impact on researchers in the field of oxidants and antioxidants. This article highlights key aspects of his career, from his early years at Brooklyn College and Yale University to his influential role at the University of California, Berkeley. His concept of the Antioxidant Network and his ability to foster international collaborations made him a respected figure in the scientific community.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Review
Cell Biology
F. Timoteo-Ferreira, D. Abreu, S. Mendes, L. Matos, A. R. Rodrigues, H. Almeida, E. Silva
Summary: The age of women having their first child is increasing, posing a major health challenge to society. Advanced maternal age is associated with decreased fertility, pregnancy complications, and offspring health issues. Ovarian aging, due to a decline in follicle number and oocyte quality, is a key contributor to female reproductive decline.
AGEING RESEARCH REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Larissa A. C. Carvalho, Rodrigo G. Queijo, Alexandre L. B. Baccaro, Adamo D. D. Siena, Wilson A. Silva Jr, Tiago Rodrigues, Silvya Stuchi Maria-Engler
Summary: Melanoma, the most aggressive type of skin cancer, is influenced by redox imbalance and redox proteins may serve as biomarkers and potential targets. Understanding genetic alterations and protein expression in melanoma patients can provide clues for new therapies.
Review
Chemistry, Multidisciplinary
Priya Chaudhary, Pracheta Janmeda, Anca Oana Docea, Balakyz Yeskaliyeva, Ahmad Faizal Abdull Razis, Babagana Modu, Daniela Calina, Javad Sharifi-Rad
Summary: Free radicals are reactive oxygen species that circulate through the body and can contribute to the development of diseases when their natural removal mechanisms are disrupted.
FRONTIERS IN CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
German Plascencia-Villa, George Perry
Summary: Alzheimer's disease is a progressive brain disorder characterized by memory and thinking impairment, with various pathological features such as abnormal protein aggregates, synaptic dysfunction, and oxidative stress. Oxidative stress, often overlooked or considered a consequence of dementia, plays a crucial role in AD progression and neuronal death. Recognizing oxidative stress as a key factor in AD has led to the development of alternative therapeutic interventions and preventive strategies for this devastating neurodegenerative disease.
Review
Environmental Sciences
Cristina Canals-Garzon, Rafael Guisado-Barrilao, Dario Martinez-Garcia, Ignacio Jesus Chirosa-Rios, Daniel Jerez-Mayorga, Isabel Maria Guisado-Requena
Summary: This systematic review found that consuming antioxidants in proper doses can have protective effects on oxidative stress and muscle damage after muscle strength exercise.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Food Science & Technology
T. R. Reshmitha, P. Nisha
Summary: The study found that lycopene (LYC) can enhance the antioxidant defense against acrylamide (ACR) and glycidamide (GLY) induced toxicity in liver cells, by increasing cell viability, reducing reactive oxygen species production, and enhancing antioxidant enzyme activity.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Review
Biochemistry & Molecular Biology
Antonio Rafael Quadros Gomes, Natasha Cunha, Everton Luiz Pompeu Varela, Heliton Patrick Cordovil Brigido, Valdicley Vieira Vale, Maria Fani Dolabela, Eliete Pereira de Carvalho, Sandro Percario
Summary: This review addresses the involvement of oxidative stress in malaria and explores the potential benefits of antioxidant supplementation as an adjuvant therapy. Malaria is a serious public health problem worldwide, and understanding its pathophysiology is crucial for eradicating the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, Research & Experimental
Idris Zubairu Sadiq
Summary: Free radicals with unpaired electrons are unstable, short-lived, and highly reactive. Excessive generation of these radicals leads to oxidative stress, causing damage to macromolecules, disrupting cell signaling pathways and antioxidants equilibrium. While lower concentrations of ROS serve as second messengers, higher concentrations cause oxidative stress and contribute to various human pathologies. Signaling pathways like NF-kappa B, MAPKs, PI3K/Akt/mTOR, and Keap1-Nrf2ARE modulate oxidative stress by increasing antioxidant defenses and decreasing ROS production. Understanding the mechanism of cell cycle redox regulation is important for disease therapy.
CURRENT MOLECULAR MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Ursula Abou-Rjeileh, G. Andres Contreras
Summary: Lipid mobilization in adipose tissues, involving lipogenesis and lipolysis, plays a crucial role in regulating systemic energy metabolism. Reactive oxygen and nitrogen species (ROS and RNS) produced during lipolysis require a robust antioxidant response to maintain redox signaling. This review explores the production of ROS and RNS in adipose tissue, their regulation of lipid mobilization, and the impact of antioxidants.
Article
Biochemistry & Molecular Biology
Mathias Flensted-Jensen, Martin Gram, Flemming Dela, Jorn Wulff Helge, Steen Larsen
Summary: In this study involving 12 sedentary obese individuals at risk of developing T2D, it was found that high intensity interval training (HIT) significantly decreased ROS production, increased antioxidant protein levels, and improved mitochondrial respiratory capacity within a short period of time. These findings suggest that a relatively small amount of HIT can effectively enhance antioxidant status and lower oxidative stress in muscle cells, potentially protecting against the development of cardiovascular disease.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Elzbieta Supruniuk, Jan Gorski, Adrian Chabowski
Summary: Muscle fatigue is a decrease in force or power due to exercise, and it is a risk factor for injuries. Exercise increases the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS), which can affect muscle force production. Low concentrations of ROS/RNS, on the other hand, can upregulate cellular adaptative responses. Exogenous antioxidant supplementation might hinder the upregulation of signaling pathways and both high and low ROS concentrations can trigger beneficial responses within a certain range.
Article
Agriculture, Dairy & Animal Science
Arletta Bielecka, Monika Jamiol, Marta Kankofer
Summary: The study investigated the influence of metabolic state on the effectiveness of antioxidant profiles in plasma and saliva during cow pregnancy, showing dynamic changes depending on the period of pregnancy course. Saliva partly reflects plasma content due to local metabolism, highlighting the need for further research to establish physiological ranges of antioxidative/oxidative profiles in cows.
Article
Hospitality, Leisure, Sport & Tourism
Aggelos Koutlas, Ilias Smilios, Eleni Maria Kokkinou, Aristides Myrkos, Anastasios Kounoupis, Konstantina Dipla, Andreas Zafeiridis
Summary: NIRS-derived muscle deoxygenation/reoxygenation indices during a single arterial occlusion-reperfusion maneuver are strongly associated with whole-body maximal indices of aerobic-fitness (VO(2)max, MAV) and may discriminate individuals with different VO(2)max. The HHb slope during occlusion was the best predictor of VO(2)max.
RESEARCH QUARTERLY FOR EXERCISE AND SPORT
(2023)
Article
Nutrition & Dietetics
Konstantinos Papanikolaou, Athanasios Z. Jamurtas, Athanasios Poulios, Panagiotis Tsimeas, Dimitrios Draganidis, Nikos V. Margaritelis, Ioannis Baloyiannis, Constantinos Papadopoulos, Apostolos Sovatzidis, Chariklia K. Deli, Anastasia Rosvoglou, Kalliopi Georgakouli, Theofanis Tzatzakis, Michalis G. Nikolaidis, Ioannis G. Fatouros
Summary: This study investigated the association between dietary nutrient intake, physical fitness, and redox status in erythrocytes and skeletal muscle. The results showed that dietary cysteine intake was positively correlated with glutathione levels and glutathione reductase activity, and negatively correlated with protein carbonyls in erythrocytes. Musculoskeletal fitness and physical activity levels were related to redox biomarkers in skeletal muscle. These findings highlight the importance of cysteine intake for optimal redox regulation and suggest that musculoskeletal fitness and physical activity may influence antioxidant capacity in skeletal muscle.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Sport Sciences
S. Methenitis, A. A. Theodorou, P. N. Chatzinikolaou, N. V. Margaritelis, M. G. Nikolaidis, V. Paschalis
Summary: The aim of this study was to compare the effect of chronic concentric or eccentric training on position sense and joint reaction angle in young men. The results showed that both types of training significantly changed position sense, reaction angle, and exercise-induced muscle damage indices after the initial training session. There were no significant changes after the final training session. The changes in position sense and reaction angle were related to the magnitude of muscle damage, rather than the type of muscle contraction.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2023)
Editorial Material
Endocrinology & Metabolism
Michalis G. Nikolaidis, Nikos Margaritelis
Summary: In biology, there is no classification of molecules as good or evil. There is limited evidence to support the consumption of antioxidants or (super) foods rich in antioxidants for their intended antioxidant effects, as they may interfere with free radicals and disrupt essential processes regulation.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Nutrition & Dietetics
Anastasios A. Theodorou, Panagiotis N. Chatzinikolaou, Nikos V. Margaritelis, Filippos Christodoulou, Themistoklis Tsatalas, Vassilis Paschalis
Summary: This study aimed to examine the effect of short-term L-citrulline supplementation on respiratory muscles' performance, fatigue, and oxygenation in older adults. The results showed that L-citrulline supplementation increased exhaled NO, but had no effects on pulmonary function, muscle oxygenation, and other parameters.
Review
Biochemistry & Molecular Biology
Nikos V. Margaritelis
Summary: Personalized interventions, especially in the field of biomedicine, have gained popularity in recent years. Moreover, redox processes have been found to play a significant role in human physiology and pathology. This review highlights methodological and statistical concepts in redox biology, and provides insights into personalized redox biology.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Olga Vasileiadou, George G. Nastos, Panagiotis N. Chatzinikolaou, Dimitrios Papoutsis, Dimitra I. Vrampa, Spyridon Methenitis, Nikos V. Margaritelis
Summary: Mammalian skeletal muscles exhibit different redox properties and antioxidant enzyme activities between slow-twitch and fast-twitch muscles. Slow-twitch muscles have higher antioxidant enzyme activity, while fast-twitch muscles have higher oxidative production. This redox heterogeneity may have implications for muscle function and health research and provide an explanation for conflicting results about antioxidant supplement efficacy.
Review
Biochemistry & Molecular Biology
Xenophon Theodoridis, Areti Triantafyllou, Lydia Chrysoula, Fotios Mermigkas, Violeta Chroni, Konstantina Dipla, Eugenia Gkaliagkousi, Michail Chourdakis
Summary: The objective of this study was to systematically review the literature and perform a meta-analysis to evaluate the effect of adherence to the DASH diet on blood pressure. The results showed that greater adherence to the DASH diet had a beneficial effect on blood pressure compared to lower adherence. Future studies should aim to standardize adherence tools and utilize rigorous study designs to further understand the potential benefits of adherence to the DASH diet in blood pressure management.
Article
Biology
Evgenia D. Cherouveim, Panagiotis G. Miliotis, Maria D. Koskolou, Konstantina Dipla, Ioannis S. Vrabas, Nickos D. Geladas
Summary: This study aimed to investigate the effect of muscle blood flow restriction during maximal exercise on hemodynamics, cerebral oxygenation, cerebral activation, and exercise performance in male participants. The results showed that exercise performance significantly deteriorated with muscle blood flow restriction, accompanied by attenuated cardiac responses. However, cerebral activation reached similar maximal levels as without restriction. In conclusion, muscle blood flow restriction limits exercise performance in trained cyclists mainly through attenuated cardiac responses.
Meeting Abstract
Peripheral Vascular Disease
Marieta Theodorakopoulou, Konstantina Dipla, Andreas Zafeiridis, Danai Faitatzidou, Aggelos Koutlas, Eleni Gkoura, Katerina Gakidi, Michael Doumas, Aikaterini Papagianni, Pantelis Sarafidis
JOURNAL OF HYPERTENSION
(2023)
Meeting Abstract
Peripheral Vascular Disease
Marieta Theodorakopoulou, Andreas Zafeiridis, Konstantina Dipla, Danai Faitatzidou, Aggelos Koutlas, Michael Doumas, Aikaterini Papagianni, Pantelis Sarafidis
JOURNAL OF HYPERTENSION
(2023)
Meeting Abstract
Peripheral Vascular Disease
Eva Pella, Maria-Eleni Alexandrou, Afroditi Boutou, Marieta Theodorakopoulou, Erasmia Sampani, Konstantina Dipla, Andreas Zafeiridis, Pantelis Sarafidis
JOURNAL OF HYPERTENSION
(2023)
Meeting Abstract
Peripheral Vascular Disease
Danai Faitatzidou, Konstantina Dipla, Marieta Theodorakopoulou, Aggelos Koutlas, Erasmia Sampani, Alexandros Tsitouridis, Chrysostomos Dimitriadis, Panagiotis Pateinakis, Andreas Zafeiridis, Aikaterini Papagianni, Pantelis Sarafidis
JOURNAL OF HYPERTENSION
(2023)
Meeting Abstract
Peripheral Vascular Disease
Danai Faitatzidou, Konstantina Dipla, Marieta Theodorakopoulou, Aggelos Koutlas, Artemios Karagiannidis, Ioannis Tsouchnikas, Panagiotis Giamalis, Chrysostomos Dimitriadis, Andreas Zafeiridis, Aikaterini Papagianni, Pantelis Sarafidis
JOURNAL OF HYPERTENSION
(2023)