Article
Geriatrics & Gerontology
Irene Lambrinoudaki, Stavroula A. Paschou, Mary Ann Lumsden, Stephanie Faubion, Evangelos Makrakis, Sophia Kalantaridou, Nick Panay
Summary: POI is the loss of ovarian activity before the age of 40, which can have significant physical and emotional consequences for patients and their families. Diagnosing and treating POI in a timely manner is crucial, but often delayed, highlighting the need for increased awareness and education within the medical community.
Article
Orthopedics
Di-chen Zhao, Xiao-yun Lin, Jing Hu, Bing-na Zhou, Qian Zhang, Ou Wang, Yan Jiang, Wei-bo Xia, Xiao-ping Xing, Mei Li
Summary: Men with osteoporosis have significantly impaired health-related quality of life, and the severity of osteoporosis is negatively correlated with quality of life. Fragility fracture is an important factor contributing to decreased quality of life. Treatment with bisphosphonates can improve the health-related quality of life in men with osteopenia/osteoporosis.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Endocrinology & Metabolism
Ian R. Reid, Anne M. Horne, Borislav Mihov, Sonja Bastin, Gregory D. Gamble
Summary: Bisphosphonates are commonly used for osteoporosis prevention and treatment, while NSAIDs are widely used by older adults at high fracture risk. A study reanalyzed data from a clinical trial of zoledronate and found that NSAID use did not affect the bone density or fracture risk reduction effects of zoledronate. The study concluded that NSAIDs do not interfere with the efficacy of potent bisphosphonates in terms of bone density or fracture.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Review
Medicine, General & Internal
Kaleen N. Hayes, Elizabeth M. Winter, Suzanne M. Cadarette, Andrea M. Burden
Summary: Bisphosphonates are the primary treatment for osteoporosis, and a drug holiday of two to three years is recommended for most patients after long-term use to reduce the risk of adverse events. Duration of bisphosphonate effects during the drug holiday and individual patient factors should be considered when determining the appropriate time to stop therapy.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Gregory A. Kline, Suzanne N. Morin, Lisa M. Lix, William D. Leslie
Summary: Bone mineral density (BMD) loss shows greater variability at shorter testing intervals, but this variability diminishes over longer intervals. Using reports of rapid BMD loss as an indication for antifracture medication initiation may not be accurate.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Gregory A. Kline, Suzanne N. Morin, Lisa M. Lix, William D. Leslie
Summary: This study examined medication adherence in women with osteoporosis before and after a fracture. The results show that many women experience a decline in medication adherence after a fracture, which is paradoxical to expectations. Fracture on therapy represents an important opportunity for clinicians to emphasize treatment adherence.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Nerea Ugartondo, Nuria Martinez-Gil, Monica Esteve, Natalia Garcia-Giralt, Neus Roca-Ayats, Diana Ovejero, Xavier Nogues, Adolfo Diez-Perez, Raquel Rabionet, Daniel Grinberg, Susanna Balcells
Summary: Osteoporosis, a common metabolic bone disorder, is often treated with nitrogen-containing bisphosphonates. Prolonged use of bisphosphonates may lead to rare atypical femoral fractures, possibly due to rare mutations in the CYP1A1 gene.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Letter
Medicine, General & Internal
Michael Liu, Rishi K. Wadhera
Summary: This study evaluates and compares the per-capita primary care physician supply in different regions of the United States between 2010 and 2019, taking into account factors such as racial and ethnic minority concentration, poverty, rurality, and region.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Review
Obstetrics & Gynecology
I. Lambrinoudaki, S. A. Paschou, M. A. Lumsden, S. Faubion, E. Makrakis, S. Kalantaridou, N. Panay
Summary: POI refers to the loss of ovarian activity before age 40, leading to hypoestrogenism and amenorrhea. Diagnosis and treatment are often delayed, highlighting the need for education in the medical community. This article aims to provide a toolkit for optimal management of women with POI.
Review
Medicine, Research & Experimental
Ahmad Oryan, Sonia Sahvieh
Summary: Osteoporosis mainly affects older individuals and postmenopausal women, with bisphosphonates (BPs) being the most effective medication for treatment. The use of zoledronate (Zol) within the BPs family shows promising results in improving bone density and preventing fractures, making it a potential treatment option for osteoporosis.
Article
Medicine, General & Internal
Bruce E. Landon, Jukka-Pekka Onnela, Laurie Meneades, A. James O'Malley, Nancy L. Keating
Summary: This study examines differences in specialist referral patterns by race among Medicare beneficiaries, showing that Black patients are shared with fewer specialists by primary care physicians compared to White patients.
Article
Endocrinology & Metabolism
Nicholas R. Fuggle, Beth Curtis, Michael Clynes, Jean Zhang, Kate Ward, Muhammad Kassim Javaid, Nicholas C. Harvey, Elaine Dennison, Cyrus Cooper
Summary: Despite significant progress in understanding osteoporosis over the past three decades, there is still a treatment gap where many high-risk individuals go untreated. This review highlights the patient, physician, and policy-related factors contributing to this gap, and focuses on discussing the efficacy and adverse effects of bisphosphonates in osteoporosis treatment, as well as strategies to improve prevention pathways for the disorder.
Article
Health Care Sciences & Services
Eve Rittenberg, Jeffrey B. Liebman, Kathryn M. Rexrode
Summary: Previous research has shown that female physicians spend more time than male physicians in the electronic health record (EHR). This study aimed to examine gender differences in EHR usage among primary care physicians and identify potential causes for those differences. The findings indicate that female primary care physicians spend more time working in the EHR and receive more staff and patient messages compared to their male colleagues.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2022)
Review
Medicine, General & Internal
SeokJoon Hwang, Minsu Seo, Dongin Lim, Min Suk Choi, Jin-Woo Park, Kiyeun Nam
Summary: This literature review investigated the characteristics and management of bisphosphonate-associated bilateral atypical femoral fractures (AFFs). A comprehensive analysis of 43 patients with bilateral AFFs revealed that 67% had prodromal symptoms, 49% occurred simultaneously, and 51% occurred sequentially. X-ray was used for initial diagnosis, with 53% having complete fractures. Surgical treatment was performed for all patients, except for those with incomplete fractures who received either surgical or medical treatments. Teriparatide was the most commonly used medication after bisphosphonate discontinuation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Sara Jane Cromer, Kristin M. D'Silva, Elaine W. Yu, Joan Landon, Rishi J. Desai, Seoyoung C. Kim
Summary: The study found that the use of denosumab has surpassed all other bone-directed therapies over the past decade, especially since its approval in 2010. The use of denosumab also showed increasing trends among patients with osteoporosis, malignancies, and recent fractures. However, it is noteworthy that the proportion of using any bone-directed therapy after fractures is low and has declined over time.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2022)
Editorial Material
Medicine, Research & Experimental
Arthur L. Caplan, Ross Upshur
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Article
Ethics
Maxwell J. Smith, Ross E. G. Upshur
JOURNAL OF BIOETHICAL INQUIRY
(2020)
Article
Health Care Sciences & Services
Joachim P. Sturmberg, Linn O. Getz, Kurt C. Stange, Ross E. G. Upshur, Stewart W. Mercer
Summary: Multimorbidity, the co-occurrence of multiple long-term conditions in an individual, poses a significant burden on healthcare systems, physicians, and patients globally. A person-focused care approach based in complexity science offers an integrated perspective on managing multimorbidity, emphasizing the importance of understanding the individual's living environment, relationships, and physiological function in addition to their medical conditions.
JOURNAL OF EVALUATION IN CLINICAL PRACTICE
(2021)
Article
Medicine, General & Internal
John Sina Moin, Richard H. Glazier, Kerry Kuluski, Alex Kiss, Ross Upshur
Summary: The study found that residing in less walkable neighborhoods was associated with a higher risk for developing multimorbidity in the future. However, the results did not reach statistical significance across all neighborhoods. Further research is needed to explore whether neighborhood walkability is a potential solution for preventing multimorbidity at the population level.
Article
Medicine, General & Internal
Xiaolin Wei, Zhitong Zhang, Marc K. C. Chong, Joseph P. Hicks, Weiwei Gong, Guanyang Zou, Jieming Zhong, John D. Walley, Ross E. G. Upshur, Min Yu
Summary: The study aimed to reduce severe cardiovascular disease events through pharmaceutical and healthy lifestyle interventions but found no significant effect over 36 months. There were significant but small differences in blood pressure changes and higher adherence to recommended medicines in the intervention group.
Review
Computer Science, Interdisciplinary Applications
Abhimanyu Sud, Darren K. Cheng, Rahim Moineddin, Erin Zlahtic, Ross Upshur
Summary: This study conducted a time series analysis of the dynamics of multidisciplinary care for chronic pain and opioid prescribing over a forty-four year period, identifying three distinct research periods and revealing a bidirectional relationship between the scientific literature and the North American opioid overdose crisis.
Article
Respiratory System
Ross Upshur, Alan Abelsohn, Anthony D'Urzo, Braden O'Neill, Farhan M. Asrar, Seyed Behnam Hashemi, Sheena Melwani, Babak Aliarzadeh
Summary: The study aimed to design a text alert system and evaluate the feasibility of delivering Air Quality Health Index (AQHI) forecast alerts to participants when AQHI readings exceeded low health risk. The results showed that delivering AQHI alerts through text messages to patients in the primary care setting was feasible, but the impact of moderate risk AQHI conditions should not be underestimated during colder seasons.
CANADIAN JOURNAL OF RESPIRATORY CRITICAL CARE AND SLEEP MEDICINE
(2022)
Article
Health Policy & Services
Michelle Howard, Kathryn Pfaff, Deborah Sattler, Lisa Dolovich, Denise Marshall, Merrick Zwarenstein, Ross Upshur
Summary: The compassionate community movement, as a public health approach and social model of care, is gaining popularity in Canada and other countries. The Windsor-Essex Compassion Care Community in Canada is a successful example that focuses on improving the quality of life, health, and wellbeing of vulnerable and aging populations through identifying and addressing social and other risks. The pilot evaluation of WECCC shows positive outcomes in participant satisfaction, changes in health and quality of life, and social connections.
HEALTH PROMOTION INTERNATIONAL
(2022)
Review
Health Care Sciences & Services
Paul Istasy, Wen Shen Lee, Alla Iansavichene, Ross Upshur, Bishal Gyawali, Jacquelyn Burkell, Bekim Sadikovic, Alejandro Lazo-Langner, Benjamin Chin-Yee
Summary: This scoping review examines the current and potential impacts of AI technologies on health equity in oncology. The review identifies three main themes: the use of AI to reduce health care disparities, concerns surrounding AI technologies and bias, and the use of AI to examine determinants of health. The study highlights the need to address gaps in the literature and ensure a more equitable integration of AI in cancer research and clinical practice.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Clinical Neurology
Fiona Webster, Laura Connoy, Abhimanyu Sud, Kathleen Rice, Joel Katz, Andrew D. Pinto, Ross Upshur, Craig Dale
Summary: There have been recent calls to re-think chronic pain in response to social inequities. Many clinically oriented accounts lack critical theoretical understanding. To truly rethink pain, we must also reconsider suffering and listen to the experiences of people with chronic pain.
Article
Multidisciplinary Sciences
Justin Ryk, Robert Simpson, Fardous Hosseiny, MaryAnn Notarianni, Martin D. Provencher, Abraham Rudnick, Ross Upshur, Abhimanyu Sud
Summary: This study aims to evaluate the effectiveness and implementation of virtually delivered Sudarshan Kriya Yoga (SKY) in improving PTSD symptoms and quality of life among Canadian veterans. The study will use a mixed-methods approach, including a randomized controlled trial and semi-structured interviews, to assess the effectiveness and implementation of the intervention.
Article
Health Care Sciences & Services
Farah Tahsin, Tujuanna Austin, Brian McKinstry, Stewart W. Mercer, Mayura Loganathan, Kednapa Thavorn, Ross Upshur, Carolyn Steele Gray
Summary: This study explores the social and behavioral factors contributing to patients' use behavior of an mHealth app called ePRO. The patient-provider relationship, personal and social circumstances, perceived usefulness, patients' previous experience with goal-related behaviors, and confidence in one's capability were identified as key factors influencing patients' decision to continue using the app. Long-term users perceived the app to be more useful and their goals to be more meaningful than short-term users.
JMIR HUMAN FACTORS
(2022)
Article
Multidisciplinary Sciences
Victoria Haldane, Archchun Ariyarajah, Isha Berry, Miranda Loutet, Fabio Salamanca-Buentello, Ross E. G. Upshur
Summary: The COVID-19 pandemic has posed challenges to health promotion and care worldwide, especially in low- and middle-income countries (LMICs). This qualitative study examines perspectives from individuals living and working in LMICs on the challenges of implementing COVID-19 vaccine programs. Through thematic content analysis, the study identifies various challenges in vaccine program implementation, including issues related to equity, governance, regulation, logistics, and service delivery. The findings emphasize the importance of focusing on safe and sustainable service delivery, strengthening end-to-end vaccine delivery systems, and promoting vaccine equity during novel infectious disease outbreaks.
Article
Ethics
Ross Upshur
Summary: This paper examines the impact of flattening the curve on long-term care residents in Ontario, Canada during the initial wave of the COVID-19 pandemic. It questions the role of healthcare systems and challenges the notion of their protection as entities. The ethical implications are explored in relation to potential challenges arising from climate change.
JOURNAL OF BIOETHICAL INQUIRY
(2023)
Review
Primary Health Care
Meena Ramachandran, Christopher Brinton, David Wiljer, Ross Upshur, Carolyn Steele Gray
Summary: This review examines the impact of eHealth on patient-provider and provider-provider relationships. The findings suggest that communication systems like telemedicine are the most discussed type of technology, and eHealth has both positive and negative impacts on relationships and/or trust. The impact is influenced by various factors such as patient-related, provider-related, technology-related, and organizational factors.