Article
Peripheral Vascular Disease
Sonia Johnson, Sanne Gordijn, Stefanie Damhuis, Wessel Ganzevoort, Mark Brown, Peter von Dadelszen, Laura A. Magee, Asma Khalil
Summary: This study used the Delphi procedure to reach consensus on diagnostic criteria and monitoring strategies for white coat hypertension in pregnancy.
Article
Medicine, General & Internal
Nurul Afzan Aminuddin, Rosnah Sutan, Zaleha Abdullah Mahdy
Summary: The study found that supplementation with palm oil vitamin E in the form of TRF is associated with significant reductions in the incidence of preeclampsia and pregnancy induced hypertension, indicating its potential as a preventive measure in public health.
FRONTIERS IN MEDICINE
(2021)
Article
Environmental Sciences
Basile Jumentier, Claire-Cecile Barrot, Maxime Estavoyer, Jorg Tost, Barbara Heude, Olivier Francois, Johanna Lepeule
Summary: High-dimensional mediation analysis is increasingly used to evaluate the indirect effects of environmental exposures on health outcomes. HDMAX2 is a new method that combines latent factor regression models and max2 tests to effectively analyze the causal role of maternal smoking during pregnancy on birth weight and gestational age. It demonstrated increased power compared to existing approaches and revealed a complex relationship between exposure and birth weight at the epigenome-wide level.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2023)
Article
Obstetrics & Gynecology
Maya Reddy, Sarah Fenn, Daniel Lorber Rolnik, Ben Willem Mol, Fabricio da Silva Costa, Euan M. Wallace, Kirsten R. Palmer
Summary: The diagnostic criteria for preeclampsia have shifted from traditional definitions to broader definitions, affecting disease diagnosis rates and outcomes. Women meeting the broader criteria show a milder phenotype of the disease, but whether this leads to improved outcomes remains uncertain.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Urology & Nephrology
Joshua Shapiro, Joel G. Ray, Eric McArthur, Nivethika Jeyakumar, Rahul Chanchlani, Ziv Harel, Ritika Arora, Alejandro Meraz-Munoz, Amit X. Garg, Michelle Hladunewich, Ron Wald
Summary: This study found that preeclampsia is a risk factor for acute kidney injury (AKI) occurring >= 90 days after delivery. It suggests the potential importance of obtaining a pregnancy history and monitoring kidney function in women with a history of hypertensive disorders of pregnancy (HDP).
AMERICAN JOURNAL OF KIDNEY DISEASES
(2022)
Article
Public, Environmental & Occupational Health
Jeffrey K. Aronson
Summary: The tools of AI have great potential in enhancing pharmacovigilance. Pharmacovigilance experts do not need to be AI experts, but should have enough knowledge to collaborate with AI experts. AI includes computational skills, visual perception, decision making, aspects of language, and combinations of these. However, limitations of AI include difficulties with language and inadequacies of databases.
Review
Cell Biology
Daniel M. Berney, Ian Cree, Vishal Rao, Holger Moch, John R. Srigley, Toyonori Tsuzuki, Mahul B. Amin, Eva M. Comperat, Arndt Hartmann, Santosh Menon, George J. Netto, Mark A. Rubin, Samra Turajlic, Maria R. Raspollini, Satish K. Tickoo
Summary: The 5th edition of the WHO Blue Book provides a comprehensive update on testicular tumours, while retaining the structure and nomenclature of the previous edition. The classification paradigm remains rooted in morphology, but important changes have been made in terms of terminology and the inclusion of new entities. The update highlights the importance of both molecular understanding and morphology in the study of testicular cancer.
Article
Health Care Sciences & Services
Conrad J. Harrison, Chris J. Sidey-Gibbons
Summary: This paper provides a practical introduction to contemporary text-data analysis techniques using freely-available software. Through NLP experiments on medicine review websites, sentiment analysis, unsupervised ML, and supervised ML algorithms were used to analyze drug reviews and predict positive or negative ratings. The results showed differences in sentiment towards different drugs and the effectiveness of the machine learning algorithms in predicting drug ratings.
BMC MEDICAL RESEARCH METHODOLOGY
(2021)
Article
Toxicology
John E. Doe, Alan R. Boobis, Samuel M. Cohen, Vicki L. Dellarco, Penelope A. Fenner-Crisp, Angelo Moretto, Timothy P. Pastoor, Rita S. Schoeny, Jennifer G. Seed, Douglas C. Wolf
Summary: Concerns over potentially carcinogenic substances have led to various classification schemes, but binary choices are not effective in managing these substances. Hence, we propose a new classification scheme that categorizes carcinogens based on their mode of action and potency, providing better guidance in their regulation and management.
ARCHIVES OF TOXICOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jan Modzelewski, Iga Siarkowska, Justyna Pajurek-Dudek, Stepan Feduniw, Katarzyna Muzyka-Placzynska, Arkadiusz Baran, Anna Kajdy, Magdalena Bednarek-Jedrzejek, Aneta Cymbaluk-Ploska, Ewa Kwiatkowska, Sebastian Kwiatkowski
Summary: This systematic review collected evidence on preeclampsia occurring before the 20th week of gestation and investigated the role of PLGF and sFlt-1 in its development. In the analyzed cases, all pregnancies with preeclampsia before the 20th week resulted in intrauterine fetal demise, and elevated SFlt-1/PLGF ratios were observed in all women. The review identified 37 reported cases worldwide, emphasizing the need for further research to establish revised definitions or new ones for this very early onset preeclampsia, which is rare but possible.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Green & Sustainable Science & Technology
Panagiotis Lemonakis, Pantelis Kopelias, Panagiotis Karlaftis
Summary: This study aims to develop an index model for assessing sections of road networks based on both pavement essential demands and surface characteristics. The fuzzy analytic hierarchy process (FAHP) is used to mathematically analyze and handle uncertainty in the index.
ENVIRONMENT DEVELOPMENT AND SUSTAINABILITY
(2023)
Review
Pathology
Kikkeri N. Naresh, L. Jeffrey Medeiros
Summary: The World Health Organization's classification of tumors of hematopoietic and lymphoid tissues has been the globally accepted standard for over 20 years. The fifth edition, a collaborative effort by pathologists, clinicians, and other specialists, builds upon the previous edition published in 2017. There are several changes in the new edition, including the addition, deletion, and revision of entities to reflect scientific and clinical advancements. Essential and desirable criteria are provided for each entity.
Article
Medicine, General & Internal
Caroline A. Crowther, Deborah Samuel, Lesley M. E. McCowan, Richard Edlin, Thach Tran, Christopher J. McKinlay
Summary: This study compared the impact of diagnosing gestational diabetes using different glycemic criteria on maternal and infant health and found that using lower glycemic criteria did not reduce the risk of overweight infants. Treating gestational diabetes can benefit maternal and infant health.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Medicine, General & Internal
Caroline A. Crowther, Deborah Samuel, Lesley M. E. McCowan, Richard Edlin, Thach Tran, Christopher J. McKinlay
Summary: This study compared the effects of different glycemic criteria for the diagnosis and treatment of gestational diabetes on women and infants. The results showed that using lower glycemic criteria did not reduce the risk of macrosomia, and it led to more labor inductions, use of health services, pharmacologic agents, and neonatal hypoglycemia. For women with glucose test results between the lower and higher criteria, those who received treatment had better maternal and infant health outcomes.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Physiology
Francisco J. Valenzuela-Melgarejo, Constanza Lagunas, Fabiola Carmona-Pasten, Kevins Jara-Medina, Gustavo Delgado
Summary: Disruption of factors in blood pressure regulation can lead to hypertension, with melatonin playing a crucial role during pregnancy in modulating physiological functions. Supplementation of melatonin can reduce blood pressure, prevent oxidative stress, and repair endothelial damage at the placental level.
FRONTIERS IN PHYSIOLOGY
(2021)
