Review
Biochemistry & Molecular Biology
Keiichi Matsubara, Yuko Matsubara, Yuka Uchikura, Takashi Sugiyama
Summary: The pathogenesis of preeclampsia involves the failure of fertilized egg implantation, release of serum factors from the hypoplastic placenta, and subsequent development of multiorgan disorders caused by vascular disorders. Exosomes play a crucial role in cell-cell communication and may be useful for evaluating preeclampsia pathophysiology and predicting the disease. Additionally, exosomes derived from mesenchymal stem cells have potential in treating preeclampsia by suppressing trophoblast apoptosis and enhancing invasive ability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Keiichi Matsubara, Yuko Matsubara, Yuka Uchikura, Katsuko Takagi, Akiko Yano, Takashi Sugiyama
Summary: Preeclampsia is a serious disease that can be fatal for both the mother and fetus. Research suggests that poor placental formation due to remodeling failure may be one of its causes. The high-mobility group protein A may play a key role in the placental formation process, and its dysfunction may be related to the pathogenesis of preeclampsia.
Article
Cell Biology
Chidambra D. Halari, Pinki Nandi, Jasmin Sidhu, Maria Sbirnac, Michael Zheng, Peeyush K. Lala
Summary: Decorin is a proteoglycan produced by chorionic villus mesenchymal cells and decidual cells during human pregnancy, and it has been shown to restrain trophoblast functions and serve as a predictive biomarker for preeclampsia. MiRNAs are involved in the pathogenesis of preeclampsia and some of them are dysregulated in placentas of preeclampsia patients. In this study, miR-512-3p was found to be induced by Decorin and upregulated in preeclampsia placentas. Functional assays revealed that miR-512-3p compromised trophoblast functions. Furthermore, the elevation of PPP3R1, a known target of miR-512-3p, was paradoxically observed in miR-512-3p-overexpressing trophoblast and preeclampsia-associated placentas.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Asli Ozmen, Ozlem Guzeloglu-Kayisli, Selcuk Tabak, Xiaofang Guo, Nihan Semerci, Chinedu Nwabuobi, Kellie Larsen, Ali Wells, Asli Uyar, Sefa Arlier, Ishani Wickramage, Hasan Alhasan, Hana Totary-Jain, Frederick Schatz, Anthony O. Odibo, Charles J. Lockwood, Umit A. Kayisli
Summary: In preeclampsia, the competition binding of IL-6 and IL-11 to gp130 impairs the function and morphology of extravillous trophoblast cells (EVT), and the reduced expression of ISG15 is associated with this effect.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Xiaobo Zhou, Xue Zhao, Wei Zhou, Hongbo Qi, Hua Zhang, Ting-li Han, Philip Baker
Summary: This study found that suppressed expression of BNIP3 in preeclampsia patients is associated with impaired mitophagy, increased mitochondrial damage, and elevated apoptosis under oxidative stress conditions.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Xue-Yun Qin, Hui-Hui Shen, Wen-Jie Zhou, Jie Mei, Han Lu, Xiao-Fang Tan, Rui Zhu, Wen-Hui Zhou, Da-Jin Li, Tao Zhang, Jiang-Feng Ye, Ming-Qing Li
Summary: This article discusses the relationship and mechanisms between autophagy and spontaneous miscarriage (SM). Autophagy plays an important role in multiple key processes during pregnancy. Aberrant autophagy has been observed in SM patients, although study findings are inconsistent. Additionally, potential treatments targeting autophagy are discussed.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biology
Jimi L. Rosenkrantz, Jessica E. F. Gaffney, Victoria H. J. Roberts, Lucia Carbone, Shawn L. Chavez
Summary: This study compared the transcriptomes of human and rhesus placenta, identifying 952 differentially expressed genes between the two species. Functional enrichment analysis of human-upregulated genes revealed associations with preeclampsia and other pregnancy disorders. Additionally, two telomerase-immortalized rhesus trophoblast cell lines were generated for in vitro studies of early placentation.
Article
Genetics & Heredity
Meijuan Zhou, Junjun Guo, Shuxian Li, Anna Li, Zhenya Fang, Man Zhao, Meihua Zhang, Xietong Wang
Summary: The study investigated the effect of PRDX1 on trophoblast function in preeclampsia. It found that PRDX1 expression was decreased in placental trophoblasts in preeclampsia patients. Knockdown of PRDX1 impaired cell migration, invasion, and tube formation abilities, and promoted apoptosis. PRDX1 regulated trophoblast function through the PTEN/AKT signaling pathway to affect cell autophagy and ROS levels.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2023)
Review
Immunology
Xiao-Wei Wei, Yu-Chen Zhang, Fan Wu, Fu-Ju Tian, Yi Lin
Summary: Uterine spiral artery remodeling plays a crucial role in successful pregnancy, which is regulated by uterine NK cells and extravillous trophoblasts.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Heyam Hayder, Guodong Fu, Lubna Nadeem, Jacob A. O'Brien, Stephen J. Lye, Chun Peng
Summary: The overexpression of miR-210-3p reduces trophoblast migration and invasion, affects EVT outgrowth in early pregnancy explants, and decreases the ability of trophoblast to form endothelial-like networks. Furthermore, miR-210-3p downregulates the expression of certain cytokines, potentially influencing EVT invasion and immune cell recruitment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Reproductive Biology
Cassandra Meakin, Emily S. Barrett, Lauren M. Aleksunes
Summary: The migration and invasion of extravillous trophoblasts are crucial for proper placenta and fetus development during pregnancy. Environmental chemicals and pharmaceuticals can disrupt trophoblast migration and may lead to adverse pregnancy outcomes.
REPRODUCTIVE TOXICOLOGY
(2022)
Review
Agriculture, Dairy & Animal Science
K. M. Davenport, M. S. Ortega, G. A. Johnson, H. Seo, T. E. Spencer
Summary: Ruminants have a unique placental structure that involves the attachment of binucleate cells to the uterine epithelium to form placental cotyledons. This understanding is crucial in analyzing pregnancy loss and improving pregnancy outcomes in ruminant animals.
Article
Immunology
Bai-Mei Zhuang, Dan-Dan Cao, Xiao-Feng Liu, Li Wang, Xiao-Li Lin, Yong-Gang Duan, Cheuk-Lun Lee, Philip C. N. Chiu, William S. B. Yeung, Yuan-Qing Yao
Summary: The human placenta is a unique temporary organ with mysterious immune tolerance. The use of trophoblast organoids and CRISPR/Cas9 technology has advanced the understanding of placental development and the role of HLA-G in trophoblast function and differentiation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Robert Morey, Omar Farah, Sampada Kallol, Daniela F. Requena, Morgan Meads, Matteo Moretto-Zita, Francesca Soncin, Louise C. Laurent, Mana M. Parast
Summary: During pregnancy, the EVT invades and remodels maternal blood vessels to ensure blood supply to the placenta, exhibiting polyploidy and senescence in early gestation. Comprehensive profiling of genomic organization and transcriptome shows that both first trimester and term EVT undergo senescence, are primarily tetraploid, and lack high rates of copy number variations. Genes and pathways related to senescence and polyploidy are important for normal EVT differentiation and maturation, with a key role identified for the unfolded protein response.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Developmental Biology
Haoyue Hu, Wenqian Chen, Zixin Tao, Zhiju Li, Jiexing He, You Peng, Jing Ma, Huiting Wen, Jing Li, Xuefei Wang, Mei Zhong
Summary: This study found that CsA may have therapeutic effects against preeclampsia by activating autophagy. The results showed that CsA alleviated PE-like symptoms, reduced placental necrosis and senescence, and upregulated autophagic protein levels.
