Article
Oncology
V Batumalai, J. Descallar, G. P. Delaney, G. Gabriel, K. Wong, J. Shafiq, S. K. Vinod, M. B. Barton
Summary: The study found that single-fraction radiation therapy (SFRT) is underused for the treatment of bone metastases in New South Wales, Australia, with a higher 30-day mortality rate compared to multi-fraction radiation therapy (MFRT). Older patients, those with lower socioeconomic status, residing in outer regional areas, or with multiple comorbidities were more likely to receive SFRT. This indicates a need to increase the utilization of SFRT for bone metastases treatment.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Qixin Wang, Jian Yang, Yingwei Wang, Hanxiang Liu, Yue Feng, Lin Qiu, Yue Chen
Summary: A new bisphosphonate radiopharmaceutical, Lu-177-DOTA-IBA, was synthesized and studied for targeted diagnosis and treatment of bone metastases. It exhibited good biological properties and safety, with promising results in a preliminary clinical translation study.
MOLECULAR PHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Gemma Di Pompo, Katsuyuki Kusuzaki, Marco Ponzetti, Vito Ferdinando Leone, Nicola Baldini, Sofia Avnet
Summary: This study explores the use of acridine orange radiodynamic therapy (AO-RDT) as a targeted anticancer treatment for bone metastasis. The results demonstrate that AO-RDT is selectively toxic to carcinoma cells, effectively inhibits tumor expansion and tumor-induced bone resorption, without affecting osteoclasts.
Review
Cell Biology
Jozef Ban, Valerie Fock, Dave N. T. Aryee, Heinrich Kovar
Summary: Bone and bone marrow are common metastatic sites of cancer, often associated with poor disease prognosis. Current therapeutic options for bone metastases are limited and mainly palliative. Further research into the molecular pathways of bone metastasis is needed to develop more successful treatments for improved patient outcomes.
Review
Oncology
Iromi R. Paranavithana, David Stirling, Montserrat Ros, Matthew Field
Summary: With recent progress in radiation therapy, precise delineation of metastatic lesions is crucial for the curative treatment of bone metastases. However, automatic segmentation algorithms for tumor segmentation still need improvement due to limited contrast and the lack of a widely agreed gold standard. Many proposed methods also lack evidence for their suitability in clinical practice.
Article
Multidisciplinary Sciences
E. A. Murphy, B. Ehrhardt, C. L. Gregson, O. A. von Arx, A. Hartley, M. R. Whitehouse, M. S. Thomas, G. Stenhouse, T. J. S. Chesser, C. J. Budd, H. S. Gill
Summary: Hip fractures are a significant cause of morbidity and mortality in the elderly, leading to high healthcare costs. This study developed a machine learning method to identify and classify hip fractures, achieving 19% higher accuracy compared to human observers. The findings suggest the potential of using machine learning in improving fracture classification and treatment outcomes.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Kohei Wakabayashi, Yutaro Koide, Takahiro Aoyama, Hidetoshi Shimizu, Risei Miyauchi, Hiroshi Tanaka, Hiroyuki Tachibana, Katsumasa Nakamura, Takeshi Kodaira
Summary: The study established a model to predict pain response following radiotherapy in patients with spinal metastasis, using a combination of clinical and radiomic features. By combining these features, the model showed high sensitivity and specificity in predicting patients who respond to radiation therapy.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Zhaoyu Chen, Zhilong Shen, Xiang Wang, Pengru Wang, Xiaofei Zhu, Jiefu Fan, Bo Li, Wei Xu, Jianru Xiao
Summary: This study aims to compare the efficacy of TKIs alone and in combination with ICIs for HCC patients, and the impact of long-term and perioperative use of BMAs on survival. The results showed that the combination of TKIs and ICIs had better efficacy, and long-term use of BMAs can prolong the survival of patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Ahmet S. Tunceroglu, Bin Gui, Shou-En Lu, Julian Sison, Rahul Parikh, Sharad Goyal, Bruce G. Haffty, Sung Kim, Salma K. Jabbour
Summary: The study investigated the efficacy of kV image guidance in the treatment of painful bone metastases, finding that its use can improve pain control, particularly for tumors of the lower extremities, extraosseous disease extension, and fewer treatment fractions.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Dirk Rades, Cansu Delikanli, Steven E. Schild, Charlotte Kristiansen, Soren Tvilsted, Stefan Janssen
Summary: For elderly cancer patients with bone metastases, a specific survival score was developed to achieve personalized treatment. This study validated the score, which was found to be more accurate than existing tools in predicting survival and death.
Article
Radiology, Nuclear Medicine & Medical Imaging
Rene Fernandez, Elisabeth Eppard, Wencke Lehnert, Luis David Jimenez-Franco, Cristian Soza-Ried, Matias Ceballos, Jessica Ribbeck, Andreas Kluge, Frank Roesch, Marian Meckel, Konstantin Zhernosekov, Vasko Kramer, Horacio Amaral
Summary: The study evaluated the safety and dosimetry of a new therapeutic radiopharmaceutical, 177Lu-DOTA-ZOL, for bone metastasis through a series of SPECT/CT images and blood samples. Results showed fast uptake and high retention in bone lesions, with a stable average retention rate in tumor lesions after injection. The red marrow was identified as the dose-limiting organ for all patients, suggesting personalized dosimetry should be considered to prevent severe hematotoxicity.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Oncology
W. L. Ong, D. L. Ball, R. L. Milne, F. Foroudi, J. L. Millar
Summary: The study found that SF-CRT for bone metastases in lung cancer patients in Australia is still underutilized, with most courses opting for ART. There is a trend of increasing ART usage over time, while SF-CRT remains fluctuating.
Review
Oncology
Doudou Jing, Qian Zhao, Yibo Zhao, Xiangdong Lu, Yi Feng, Bin Zhao, Xiaofeng Zhao
Summary: Cancer-induced bone pain (CIBP) significantly affects patients' quality of life and their physical and mental health. The current management of CIBP follows the World Health Organization's three-step analgesic therapy algorithm. Opioids, the first-line treatment for moderate-to-severe cancer pain, have limitations due to addictive properties and gastrointestinal side effects. Different approaches such as surgery, radiotherapy, or antibodies and inhibitors targeting nerve growth factors and bone resorption can effectively reduce the incidence and improve the management of cancer pain. This review aims to explore the underlying mechanisms and potential therapeutic strategies to optimize the management of CIBP.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Naoya Ishibashi, Toshiya Maebayashi, Yuki Kimura, Masahiro Okada
Summary: This study investigated the relationship between pre-radiation therapy bone scan index (BSI) and overall survival (OS) in patients with bone metastases from cancers other than breast or prostate cancer. The study found no significant association between BSI and OS, but identified age, type of bone metastases, and type of cancer as significant factors affecting OS.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2022)
Article
Biology
Saskia Magdalen Sachsenmaier, Frank Traub, Anna Cykowska, Rosa Riester, Nikolaus Wuelker, Christian Walter, Marina Danalache
Summary: Bone metastases are typically associated with a short-term prognosis. Photodynamic therapy (PDT) emerges as a promising alternative treatment for targeting metastatic lesions. The study found that PDT treatment had different effects on primary and human bone metastatic cancer cell lines, showing potential applicability in treating invasive ductal carcinoma.
