4.7 Article

One-pot transition-metal free transamidation to sterically hindered amides

Journal

ORGANIC CHEMISTRY FRONTIERS
Volume 5, Issue 20, Pages 2950-2954

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c8qo00591e

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Funding

  1. Science and Technology Planning Project of Guangdong Province [2017A010103017]
  2. National Natural Science Foundation of China [21272080]
  3. Special Innovation Projects of Common Universities in Guangdong Province [20178S0182]

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One-pot synthesis of a variety of amides including sterically hindered amides from primary amides catalyzed by cesium fluoride has been developed for the first time. Primary amides provided sterically hindered amides in good yields (up to 86%), by transamidation, catalyzed by cesium fluoride, after a simple Boc-activation.

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