Article
Chemistry, Organic
Linglong Ding, Yi-Hui Deng, Tian-Yu Sun, Dawei Wang, Yun-Dong Wu, Xiao-Feng Xia
Summary: Through the control by functional groups, a catalytic divergent cycloisomerization of 1,6-enynes was achieved using a combination of a Pd(0) catalyst with glucose for the synthesis of pyrrole, cyclopentene, and tetra-hydropyridine derivatives. Detailed DFT calculations have provided evidence for the different pathways of selective cyclization/isomerization.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Physical
Kairui Liu, Bolortuya Badamdorj, Fan Yang, Michael J. Janik, Markus Antonietti
Summary: The presence of water has a significant impact on enzyme-catalyzed biological reaction systems. Single atom catalysts have the potential to mimic biological enzymes. In this study, we report the significant promotion of water in the reduction of nitrobenzene using a Pt single atom catalyst.
APPLIED CATALYSIS B-ENVIRONMENTAL
(2022)
Review
Chemistry, Inorganic & Nuclear
Ekaterina S. Gulyaeva, Elena S. Osipova, Ruqaya Buhaibeh, Yves Canac, Jean-Baptiste Sortais, Dmitry A. Valyaev
Summary: This paper provides a comprehensive review of the rapidly emerging application of organometallic manganese complexes in catalytic reactions. It focuses on the influence of different donor ligands on catalytic activity and selectivity, the comparison with polydentate systems, and the study of mechanistic aspects.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Chemistry, Physical
Zhengliang Yin, Fusen Yang, Juanrong Chen, Chaozhong Sun, Shunsheng Cao
Summary: This study demonstrates the successful chemoselective hydrogenation of nitroarenes and unsaturated aldehydes by encapsulating silver nanoparticles into hierarchical hollow silica, resulting in the formation of amino and hydroxyl groups.
APPLIED CATALYSIS A-GENERAL
(2022)
Article
Chemistry, Physical
Catherine Gazolla Santana, Michael J. Krische
Summary: Catalytic carbonyl reductive couplings facilitated by hydrogenation, transfer hydrogenation, and hydrogen autotransfer allow unsaturated hydrocarbons to substitute organometallic reagents for C-C bond formation without the need for stoichiometric metals, addressing issues of safety and challenges in large-scale implementation.
Article
Multidisciplinary Sciences
Dawei Cao, Chen-Chen Li, Huiying Zeng, Yong Peng, Chao-Jun Li
Summary: The study presents a method for constructing C(sp(3))-C(sp(3)) bonds using a nickel-catalyzed reductive coupling of moisture and air-stable hydrazones, with broad substrate scope and harmless by-products. The method demonstrates high functional group compatibility and practicality in the application to biological molecules.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Organic
Ting Liang, Guichao Dong, Chuang Li, Xin Xu, Zhou Xu
Summary: A range of medium-sized cyclic ethers can be effectively synthesized through intramolecular reductive coupling of dialdehydes initiated by AgNTf2 and hydrosilane at room temperature. The method is characterized by its broad functional group compatibility, high product diversity, high efficiency, and utility in the late-stage modification of complex molecules.
Review
Chemistry, Multidisciplinary
Patrick D. Parker, Xintong Hou, Vy M. Dong
Summary: Tandem catalysis allows for constructing complex structures quickly from simple building blocks to address diverse challenges. This article focuses on using tandem hydrogenation to prepare complex natural products and presents tandem catalysis involving transfer hydrogenation. Lastly, recent breakthroughs and opportunities for asymmetric hydrogenation are highlighted.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Review
Chemistry, Inorganic & Nuclear
Chandan Das, Jagrit Grover, Tannu, Ayon Das, Debabrata Maiti, Arnab Dutta, Goutam Kumar Lahiri
Summary: This article discusses the frontier research and potential future directions of CO2 hydrogenation to methanol and formic acid using transition metal complexes as catalysts.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Organic
Samanta Yadav, Divya Prabha, Deepali Ahluwalia, Arijit Bag, Rajeev Gupta
Summary: Cobalt complexes of amide-based ligands appended with protonated heterocyclic rings are efficient catalysts for the transfer hydrogenation of various carbonyl compounds. They can convert aldehydes and ketones into primary and secondary alcohols, respectively, and also exhibit good catalytic performance towards biologically relevant substrates.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Qi Guo, Jingchao Chen, Guoli Shen, Guangfu Lu, Xuemei Yang, Yan Tang, Yuanbin Zhu, Shiyuan Wu, Baomin Fan
Summary: A metal-free, environmentally benign, simple, and efficient transfer hydrogenation process for quinoxaline has been developed using HBpin as a hydrogen source. This reaction is compatible with a variety of quinoxalines, producing desired tetrahydroquinoxalines in moderate-to-excellent yields with Bu4NBr as a noncorrosive and low-cost catalyst.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Thomas G. Linford-Wood, Nathan T. Coles, Ruth L. Webster
Summary: This study reports the reduction of carbon-carbon double bonds using a three-coordinate iron(ii) beta-diketiminate pre-catalyst, employing poly(methylhydrosiloxane) as the hydride donor and a bio-alcohol as the proton source. The results show that allyl arene substrates, styrenes, and aliphatic substrates can all undergo reduction at room temperature using n-butanol and ethanol. Additionally, by changing the deuterium source to d-aniline, high regioselectivity for mono-deuteration of the terminal position of the double bond can be achieved.
Article
Chemistry, Inorganic & Nuclear
Yinyin Chen, Tianhua Cui, Hua Chen, Xue Li Zheng, Haiyan Fu, Ruixiang Li
Summary: A new series of cationic ruthenium(II) complexes with 2,6-bis(1-R-5-methyl-pyrazol-3-yl) pyridine ligands were synthesized and characterized. Complex 1 showed superior selectivity towards aldehydes in the acceptorless dehydrogenation of primary alcohols, providing high yields of up to 99% under mild conditions. It also served as a promising catalyst in the sequential AD/condensation reaction of primary and secondary alcohols, producing α,β-unsaturated ketones in moderate to good selectivity.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Multidisciplinary
Bangkui Yu, Renbin Huang, Renren Li, Haocheng Zhang, Hanmin Huang
Summary: This study describes a silver-catalyzed chemodivergent cyclization of alkyne-tethered aldehydes with aminals to produce aminomethylated 1H-isochromenes and naphthols by tuning the reaction conditions. The reaction shows broad substrate generality and functional group compatibility. Mechanistic studies reveal that the aminomethylated naphthols are formed through a silver-catalyzed unusual rearrangement of the resulting N,O-aminal-containing isochromenes.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Organic
Zhen Luo, Xue Zhang, Zheng-Qiang Liu, Chuan-Ming Hong, Qing-Hua Li, Tang-Lin Liu
Summary: This study presents a ruthenium-catalyzed intra-molecular aryl migrative isomerization, providing a mild and environmentally friendly method for synthesizing ketones with high step-and atom-economy and broad substrate scope. Additionally, the researchers discovered a heuristic paradigm for transition-metal-catalyzed C-C activation.
Article
Fisheries
Yingrui Li, Lin Su, Baoshan Guo, Shun Zhou, Chao Li, Yunji Xiu
Summary: Pathogens infection induces intestinal inflammatory processes. MicroRNAs in teleost serve as vital regulators in innate immunity responses against pathogen infection. MiR-144-5p is identified as negative regulator in teleost against bacterial infection. It down-regulates inflammation-related cytokines by targeting Hsp90 alpha, ultimately promoting bacterial infection.
Article
Fisheries
Hui Jun Huo, Tian Zhen Yang, Qing Zhu, Ning Yang, Chao Li
Summary: This study compared collectins from a range of vertebrates and found that they are widely distributed and conserved. The collectin from a marine teleost, the black rockfish, was analyzed in detail, revealing the need for further research on its sugar binding mechanism.
Article
Engineering, Environmental
Dandan Liang, Zeng Li, Guohong Liu, Chao Li, Weihua He, Jiannan Li, Yujie Feng
Summary: Periodic polarity reversal strategy can effectively cultivate bidirectional electron transfer biofilm and utilize the characteristics of biofilm to facilitate nitrate reduction.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Fisheries
Min Cao, Qi Li, Xiantong Liu, Qiang Fu, Chao Li
Summary: Sebastes schlegelii is a fish species with high economic value, but the outbreak of diseases in its aquaculture industry has caused significant economic losses. Study of the fish immune system, particularly the immunoglobulin genes, can provide insights into the immune response to pathogens and contribute to the development of prevention and control methods. This study successfully identified and cloned the immunoglobulin heavy chain genes (sIgM, mIgM, sIgT, and mIgT) of S. schlegelii, revealing their high conservation during evolution.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Juan D. D. Lasso, Durbis J. J. Castillo-Pazos, Malcolm Sim, Joaquin Barroso-Flores, Chao-Jun Li
Summary: Despite being well-known for their photochemical properties and industrial value, the use of nitroarenes as a productive photochemical handle in organic synthesis has been relatively unexplored. In this study, we report the design and application of a sulfinate-nitroarene electron donor-acceptor (EDA) complex, which enabled the first light mediated catalyst-free synthesis of N-hydroxy-sulfonamides. The EDA complex was characterized spectroscopically and studied using DFT and TD-DFT calculations. A total of 32 examples with electron withdrawing and electron donating groups were synthesized under oxygen- and water-tolerant conditions.
Article
Chemistry, Organic
Jiaxin Yao, Lin Yu, Wengui Duan, Chao-Jun Li
Summary: This study developed a novel method for the synthesis of arylsilane via Pd-catalyzed cross-coupling of hexamethyldisilane with nitroarenes. The method exhibits high selectivity and utilizes readily accessible chemical feedstocks.
ORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Multidisciplinary Sciences
Jing-Tan Han, Hui Su, Lida Tan, Chao-Jun Li
Summary: Gallium nitride (GaN), as a methane-active semiconductor, can catalyze the photooxidation of methane and selectively control the production of methanol and formic acids by regulating the O2 content in water, without generating overoxidation products. The controllable generation of moderately reactive oxygen radicals (center dot OOH and center dot OH) in combination with direct methane activation by GaN is responsible for the highly selective reactivity and tunability through a photo-generated radical process.
Article
Pediatrics
Mei Mei, Dan Dai, Zhuoyao Guo, Congcong Zhang, Jing Liu, Yuanyuan Qi, Xiaochuan Wang, Libo Wang, Liling Qian
Summary: This study retrospectively analyzed the clinical characteristics and underlying causes of 551 hospitalized children with recurrent pneumonia from January 2016 to January 2021 at the Children's Hospital of Fudan University. The majority (87.7%) of the children had underlying causes, with recurrent aspiration, primary immunodeficiency, and congenital heart diseases being the most common. Genetic defects were identified in about a quarter of the patients. Primary immunodeficiency, primary ciliary dyskinesia, bronchiolitis obliterans, and the age of >3 years at diagnosis were risk factors for severe outcomes. Aspiration and an abnormal family history were risk factors for rehospitalization.
PEDIATRIC PULMONOLOGY
(2023)
Article
Endocrinology & Metabolism
Peng Wang, Haifeng Sun, Gulisudumu Maitiabula, Li Zhang, Jianbo Yang, Yupeng Zhang, Xuejin Gao, Jieshou Li, Bin Xue, Chao-Jun Li, Xinying Wang
Summary: Total parenteral nutrition (TPN) can cause glucose metabolism disorders by altering the gut microbiota and its metabolites, leading to insulin resistance and an increased risk of complications. Decreased levels of Lactobacillaceae and indole-3-acetic acid (IAA) are associated with these complications, while the abundance of Lactobacillaceae and IAA is negatively correlated with insulin resistance and serum lipopolysaccharide levels. IAA activates the aryl hydrocarbon receptor and increases glucagon-like peptide-1 secretion, preventing TPN-induced glucose metabolism disorders in mice.
Article
Chemistry, Multidisciplinary
Hyotaik Kang, Lida Tan, Jing-Tan Han, Chia-Yu Huang, Hui Su, Aleksei Kavun, Chao-Jun Li
Summary: We demonstrate the use of gallium nitride (GaN) as a non-toxic, recyclable, heterogeneous photocatalyst in conjunction with the catalytic use of benzophenone to activate alkyl C(sp(3))-H bonds and generate alkyl radicals. This dual photocatalytic cycle enables cross-dehydrogenative Minisci alkylation under mild and chemical oxidant-free conditions.
COMMUNICATIONS CHEMISTRY
(2023)
Article
Chemistry, Organic
Yi-Zhan Wang, Shao-Dong Liu, Liang Cheng, Li Liu, Chao-Jun Li
Summary: An asymmetric umpolung addition of hydrazones as alkyl carbanion equivalents with imines in water was developed using a Ru-diamine-diphosphine system in the presence of crown ether. Chiral amines were obtained in moderate to good yields with high enantioselectivities. The use of water as a reaction medium provided better yields and enantioselectivities compared to organic solvents, offering a new method for the green and sustainable synthesis of chiral amines.
ORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Cell Biology
Chuanming Liu, Wu Zuo, Guijun Yan, Shanshan Wang, Simin Sun, Shiyuan Li, Xinyi Tang, Yifan Li, Changjun Cai, Haiquan Wang, Wenwen Liu, Junshun Fang, Yang Zhang, Jidong Zhou, Xin Zhen, Tianxiang Feng, Yali Hu, Zhenbo Wang, Chaojun Li, Qian Bian, Haixiang Sun, Lijun Ding
Summary: With aging, abnormalities during oocyte meiosis become more prevalent, and the mechanisms of aging-related oocyte aneuploidy are not fully understood. This study reveals that disruptions in the mevalonate (MVA) pathway in granulosa cells (GCs) contribute to meiotic defects and aneuploidy in oocytes. Supplementation with MVA metabolites improves oocyte quality, suggesting a potential therapeutic strategy for promoting female reproductive longevity.
Article
Chemistry, Organic
Ruohua Gui, Chao-Jun Li
Summary: Historically, deuteration reactions were mainly used for mechanistic studies, but their pharmacological importance is now recognized. Efforts have been made to meet the urgent need for deuteration tools since the approval of the first deuterated drug for Huntington's disease. Current deuteration strategies involving reversible H/D exchange have limitations in functional group tolerance and deuterium content. In this study, a ruthenium-catalyzed deoxygenative deuteration of ketones was developed, allowing regiospecific deuteration with high deuterium content.
ORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Multidisciplinary
Durbis J. Castillo-Pazos, Juan D. Lasso, Ehsan Hamzehpoor, Jorge Ramos-Sanchez, Jan Michael Salgado, Gonzalo Cosa, Dmytro F. Perepichka, Chao-Jun Li
Summary: Recently, the photochemistry of Electron Donor-Acceptor (EDA) complexes using electron donors as catalytic agents has gained interest in the field of catalysis. This methodology allows for the separation of electron transfer from the bond-forming event. In this study, an EDA complex between triarylamines and alpha-perfluorosulfonylpropiophenone reagents was discovered. It catalyzes C-H perfluoroalkylation of arenes and heteroarenes under visible light irradiation in pH- and redox-neutral conditions. The mechanism of this reaction was elucidated through a detailed photophysical characterization of the EDA complex, triarylamine radical cation, and its turnover event.
Article
Chemistry, Physical
Mingxin Liu, Zewen Wu, Xianghua Kong, Xu Zhang, Lida Tan, Hong Guo, Chao-Jun Li
Summary: A novel synthesis of toluene using GaN semiconductor nanowire arrays as catalyst is reported. The GaN nanowire arrays can synergistically facilitate the facile generation of toluene from methane and methanol under photo-irradiation or thermal conditions. Detailed computational studies revealed different mechanisms involved in the photo- and thermal-toluene synthesis.
