4.7 Article

Cationic gold(I)-catalyzed enantioselective hydroalkylation of unactivated alkenes: influence of the chloride scavenger on the stereoselectivity

Journal

ORGANIC CHEMISTRY FRONTIERS
Volume 1, Issue 6, Pages 608-613

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4qo00112e

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Funding

  1. ANR JCJC HAONA
  2. UPS
  3. CNRS
  4. Chinese Scholarship Council
  5. IUF

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Enantioselective intramolecular additions of beta-ketoamides to unactivated alkenes have been accomplished by means of gold catalysis. Chiral LAuCl complexes have been activated by various Lewis acids (Cu, Ag, Ga, In, Si, Bi etc.). The influence of these activators on the stereoselectivity has been studied.

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