Journal
CENTRAL EUROPEAN JOURNAL OF CHEMISTRY
Volume 6, Issue 4, Pages 562-568Publisher
VERSITA
DOI: 10.2478/s11532-008-0064-x
Keywords
Antifungal; Biginelli compounds; Boron; 3,4-dihydropyrimidin-2(1H)-(thio)ones; Monastrol
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Funding
- Canada Research Chairs Program, the Canadian Foundation for Innovation/Atlantic Innovation Fund
- Merck Frosst Canada and Co
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The addition of formylphenylboronic acid derivatives to thiourea and ethyl acetoacetate proceeds in the presence of an additional Lewis acid catalyst to give the corresponding 3,4-dihydropyrimidin-2(1H)-(thio)ones (Biginelli products) in moderate yield. Compounds were tested for antifungal activity against pure cultures of Aspergillus niger, Aspergillus flavus, Candida albicans and Saccharomyces cerevisiae but, unfortunately, none showed any appreciable activity.
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