Treatment-naïve HPV+ head and neck cancers display a T-cell-inflamed phenotype distinct from their HPV- counterparts that has implications for immunotherapy

Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer

(2018) Katherine A. Hoadley et al.   CELL

Expression of the Chemokine Receptor CXCR3 Correlates with Dendritic Cell Recruitment and Prognosis in Gastric Cancer

(2018) Fangfang Chen et al.   Genetic Testing and Molecular Biomarkers

The Immune Landscape of Cancer

(2018) Vésteinn Thorsson et al.   IMMUNITY

Immunological network analysis in HPV associated head and neck squamous cancer and implications for disease prognosis

(2018) Xiaohang Chen et al.   MOLECULAR IMMUNOLOGY

Prognostic Significance of PD-L1 + and CD8 + Immune Cells in HPV + Oropharyngeal Squamous Cell Carcinoma

(2018) Benjamin Solomon et al.   Cancer Immunology Research

Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates

(2018) Yannick Simoni et al.   NATURE

Dynamic balance between master transcription factors determines the fates and functions of CD4 T cell and innate lymphoid cell subsets

(2017) Difeng Fang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Molecular mechanisms underlying human papillomavirus E6 and E7 oncoprotein-induced cell transformation

(2017) Suruchi Mittal et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Therapeutic T cell engineering

(2017) Michel Sadelain et al.   NATURE

Tumor Mutational Burden and Response Rate to PD-1 Inhibition

(2017) Mark Yarchoan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors

(2017) Bertrand Routy et al.   SCIENCE

Analysis of Class I Major Histocompatibility Complex Gene Transcription in Human Tumors Caused by Human Papillomavirus Infection

(2017) Steven Gameiro et al.   Viruses-Basel

The prognostic role of tumor infiltrating T-lymphocytes in squamous cell carcinoma of the head and neck: A systematic review and meta-analysis

(2017) Emma J. de Ruiter et al.   OncoImmunology

Ten Years of Progress in Head and Neck Cancers

(2017) Shrujal Baxi et al.   Journal of the National Comprehensive Cancer Network

Tumor infiltrating lymphocytes and survival in patients with head and neck squamous cell carcinoma

(2016) Nghia Nguyen et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation

(2016) Ana C. Anderson et al.   IMMUNITY

Human Papillomavirus Drives Tumor Development Throughout the Head and Neck: Improved Prognosis Is Associated With an Immune Response Largely Restricted to the Oropharynx

(2016) Ankur Chakravarthy et al.   JOURNAL OF CLINICAL ONCOLOGY

Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients

(2016) Alena Gros et al.   NATURE MEDICINE

Unlocking tumor vascular barriers with CXCR3: Implications for cancer immunotherapy

(2016) Maryann E. Mikucki et al.   OncoImmunology

Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy

(2015) Suzanne L. Topalian et al.   CANCER CELL

PGE2 Elevates IL-23 Production in Human Dendritic Cells via a cAMP Dependent Pathway

(2015) Quanxing Shi et al.   MEDIATORS OF INFLAMMATION

Tetanus toxoid and CCL3 improve dendritic cell vaccines in mice and glioblastoma patients

(2015) Duane A. Mitchell et al.   NATURE

Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity

(2015) Stefani Spranger et al.   NATURE

Comprehensive genomic characterization of head and neck squamous cell carcinomas

(2015)   NATURE

Robust enumeration of cell subsets from tissue expression profiles

(2015) Aaron M Newman et al.   NATURE METHODS

Integrative Analysis of Head and Neck Cancer Identifies Two Biologically Distinct HPV and Three Non-HPV Subtypes

(2014) M. K. Keck et al.   CLINICAL CANCER RESEARCH

Intratumoral regulatory T cells upregulate immunosuppressive molecules in head and neck cancer patients

(2013) H-B Jie et al.   BRITISH JOURNAL OF CANCER

Evidence for a Role of the PD-1:PD-L1 Pathway in Immune Resistance of HPV-Associated Head and Neck Squamous Cell Carcinoma

(2013) S. Lyford-Pike et al.   CANCER RESEARCH

The epidemic of human papillomavirus and oropharyngeal cancer in a Canadian population

(2013) A.C. Nichols et al.   Current Oncology

Innate and adaptive immune cells in the tumor microenvironment

(2013) Thomas F Gajewski et al.   NATURE IMMUNOLOGY

Interferon-gamma and interleukin-10 production by mononuclear cells from patients with advanced head and neck cancer

(2012) LC Conti-Freitas et al.   Clinics

Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008

(2010) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

HPV-associated head and neck cancer: a virus-related cancer epidemic

(2010) Shanthi Marur et al.   LANCET ONCOLOGY

Human Papillomavirus and Survival of Patients with Oropharyngeal Cancer

(2010) K. Kian Ang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Regulation of TH17 cells in the mucosal surfaces

(2009) Daniel Mucida et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Improved Survival of Patients With Human Papillomavirus-Positive Head and Neck Squamous Cell Carcinoma in a Prospective Clinical Trial

(2008) C. Fakhry et al.   JNCI-Journal of the National Cancer Institute