Journal
ONCOIMMUNOLOGY
Volume 3, Issue 6, Pages -Publisher
LANDES BIOSCIENCE
DOI: 10.4161/onci.29126
Keywords
BRAF; melanoma; T cell; CD40L; IFN gamma
Categories
Funding
- Howard Hughes Medical Institute Funding Source: Medline
- NCI NIH HHS [P50 CA121974] Funding Source: Medline
- NIAID NIH HHS [R01 AI074699] Funding Source: Medline
Ask authors/readers for more resources
The establishment of an immunosuppressive tumor microenvironment is a hallmark feature driving cancer cell evasion of immunosurveillance. In a murine melanoma model, we recently demonstrated that decreased intratumoral CD4(+) T-cell expression of CD40L and interferon gamma (IFN gamma) is critical to maintain this immunosuppressive microenvironment. Altered effector functions of tumor-associated CD4(+) T cells is essential for B-Raf(V600E) inhibitor-mediated restoration of antitumor immunity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available