Antibody-based depletion of Foxp3+T cells potentiates antitumor immune memory stimulated by mTOR inhibition

Inhibition of mTOR signaling enhances antitumor memory T lymphocytes while increasing the frequency of immunosuppressive regulatory T cells (Tregs). We report a strategy to further improve the quality and function of CD8(+) memory T cells using CD4-depleting monoclonal antibody therapy. Removal of Tregs was the mechanism underlying immunological memory formation following CD4 depletion.