Journal
ONCOIMMUNOLOGY
Volume 2, Issue 7, Pages -Publisher
LANDES BIOSCIENCE
DOI: 10.4161/onci.24661
Keywords
dendritic cell; imaging; migration; immunotherapy; F-19 MRI
Categories
Funding
- Dutch Cancer Society [KUN 2008/035]
- Netherlands Organization for Scientific Research (NWO) [920-03-250, NWO-Veni 700.10.409, NWO-Vidi-917.76.363, AGIKO-92003250]
- Radboud University Nijmegen Medical Centre [AGIKO-2008-2-4]
- ATK foundation
- ENCITE
- NWO Spinoza award
- European Research Council (ERC) [ERC-2010-AdG-269019-PATHFINDER, KWF2009-4402]
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Dendritic cell (DC)-based vaccines require the cells to relocate to lymph nodes (LNs). Unfortunately, however, DC migration rates are typically very poor. We investigated strategies to increase the migration efficacy of DC-based vaccines. Surprisingly, a reduction in DC number, but not the conditioning of the injection site, improved LN targeting.
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